Ocorrência de seis casos suspeitos, autóctones sorologicamente positivos ()

Ferraroni, José João; Melo, J. A. Nunes de; Camargo, M. E.

doi:10.1590/1809-43921977073438

Cited by 22 publications

(14 citation statements)

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“…The (19)(20)(21)(22)(23)(24)(25)(26)(27)(28). In A, population density increased 2.5-fold in the last three decades; in B, acute T. cruzi infections increased several-fold in the same timespan.…”

Section: Methodsmentioning

confidence: 99%

“…Since 1924, when T. cruzi infection in wild squirrel monkeys (Crisotrix sciureus) was described (20), sporadic human T. cruzi infections have been reported in the basin (21). However, this enzootic protozoan infection received attention only after 1969, when acute cases of human Chagas disease were described in Belém, State of Pará, Brazil (22,23). Further evidence shows that T. cruzi infections are endemic in the Amazon Basin (12)(13)(14)(15)(21)(22)(23)(24)(25)(26)(27)(28) (Figures 1 and 2).…”

Section: Researchmentioning

confidence: 99%

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Emerging Chagas Disease: Trophic Network and Cycle of Transmission ofTrypanosoma cruzifrom Palm Trees in the Amazon

Teixeira

Monteiro

Rebêlo

et al. 2001

Emerg. Infect. Dis.

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Section: Methodsmentioning

confidence: 99%

Section: Researchmentioning

confidence: 99%

Emerging Chagas Disease: Trophic Network and Cycle of Transmission ofTrypanosoma cruzifrom Palm Trees in the Amazon

Teixeira

Monteiro

Rebêlo

et al. 2001

Emerg. Infect. Dis.

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“…Em 1977 foram detectados os seis primeiros casos de infecção chagásica humana autóctone do Estado do Amazonas em piaçabeiros do Município de Barcelos 5 , surgindo novas publicações em 1978 6 . Por outro lado, já foram encontradas dez das 16 espécies de triatomíneos descritas na região, e mais de 100 espécies de mamíferos de pequeno e médio porte, naturalmente infectados com o Trypanosoma cruzi [7][8][9] .…”

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Morbidade da doença de Chagas em pacientes autóctones da microrregião do Rio Negro, Estado do Amazonas

Brum-Soares¹,

Xavier²,

Sousa³

et al. 2010

Rev. Soc. Bras. Med. Trop.

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RESUMO ABSTRACTIntroduction. A seroepidemiological and clinical study was conducted on 152 autochthonous individuals living in the district of Barcelos, State of Amazonas, to evaluate the seroprevalence of Chagas infection and morbidity of Chagas disease. Methods. The serological tests used were indirect immunofluorescence, conventional and recombinant ELISA and immunoblot (Tesa-blot). Thirty-eight patients were considered seropositive; 31 were considered serodoubtful; and 83 were considered seronegative. The 38 seropositive cases were paired with 38 seronegative controls of the same age and sex, and underwent epidemiological and clinical evaluations, electrocardiograms and echocardiograms. Twenty-nine pairs underwent radiological examinations of the esophagus. Results. Seropositivity was 19.9 times more frequent among workers gathering plant materials from the forests and 10.4 times more frequent among piassaba gatherers. Eighty six point seven percent of the seropositive individuals recognized the genus Rhodnius as the local vector, while only 34.2% of the seronegative individuals recognized this. The EKG was abnormal in 36.8% of the seropositive individuals and in 21.5% of the seronegative individuals, while the echocardiogram showed abnormalities in 31.6% of the seropositive and 18.4% of the seronegative individuals. Precordialgia and palpitation were more frequent among the seropositive individuals. Clinical evaluation on the digestive system and X-ray on the esophagus did not show significant abnormalities. Conclusions.

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“…In the State of Amazonas, chronic Chagas disease has lower morbidity than in classic endemic areas, appearing mainly in the latent form 1,5 . Chagasic infection was first reported in this state by Ferraroni et al 13 , who examined 25 individuals who performed piassava fiber extraction in the municipality of Barcelos, and found 6 individuals with positive serological test results. Cross-sectional assessments, including the clinical and radiological evaluations of anti-T. cruzi seropositive patients in the Rio Negro micro-region, ratified the high seroprevalence of chagasic infection in this region and showed a clinical profile of low morbidity and mortality in the chronic phase of the disease [5][6][7] .…”

Section: Ethical Considerationsmentioning

confidence: 98%

Biological behavior of Trypanosoma cruzi stocks obtained from the state of Amazonas, Western Brazilian Amazon, in mice

Monteiro

Magalhães

Oliveira

et al. 2012

Rev. Soc. Bras. Med. Trop.

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Introduction:The biological diversity of circulating Trypanosoma cruzi stocks in the Amazon region most likely plays an important role in the peculiar clinic-epidemiological features of Chagas disease in this area. Methods: Seven stocks of T. cruzi were recently isolated in the State of Amazonas, Brazil, from humans, wild mammals, and triatomines. They belonged to the TcI and Z3 genotypes and were biologically characterized in Swiss mice. Parasitological and histopathological parameters were determined. Results: Four stocks did not promote patent parasitemia in mice. Three stocks produced low parasitemia, long pre-patent periods, and a patent period of 1 day or oscillating parasitemia. Maximum parasitemia ranged from 1,400 to 2,800 trypomastigotes/0.1mL blood. Mice inoculated with the T. cruzi stocks studied showed low positivity during fresh blood examinations, ranging from 0% to 28.6%. In hemoculture, positivity ranged from 0% to 100%. Heart tissue parasitism was observed in mice inoculated with stocks AM49 and AM61. Stock AM49 triggered a moderate inflammatory process in heart tissue. A mild inflammatory process was observed in heart tissue for stocks AM28, AM38, AM61, and AM69. An inflammatory process was frequently observed in skeletal muscle. Examinations of brain tissue revealed inflammatory foci and gliosis in mice inoculated with stock AM49. Conclusions: Biological and histopathological characterization allowed us to demonstrate the low infectivity and virulence of T. cruzi stocks isolated from the State of Amazonas. Keywords: Chagas disease. Trypanosoma cruzi. Virulence. Pathogenicity. Swiss mice. Amazon. RESUMO Introdução:A diversidade biológica dos estoques Trypanosoma cruzi circulantes na Região Amazônica pode desempenhar importante papel nas características clínico-epidemiológicas peculiares da doença de Chagas nesta área. Métodos: Sete isolados de T. cruzi do Estado do Amazonas provenientes de humanos, mamíferos silvestres e triatomíneos, pertencentes aos genótipos TcI e Z3, foram biologicamente caracterizados em camundongos Swiss. Foram avaliados parâmetros parasitológicos e histopatológicos. Resultados: Quatro isolados não produziram parasitemia patente em camundongos. Três isolados promoveram baixa parasitemia com longos períodos pré-patentes, período patente de um dia ou parasitemia oscilante. A parasitemia máxima variou de 1.400 a 2.800 tripomastigotas/0,1mL de sangue. Os camundongos inoculados com os isolados estudados mostraram baixa positividade no exame a fresco, variando de 0 a 28,6%. Para a hemocultura, a positividade variou de 0 a 100%. Parasitismo cardíaco foi observado em camundongos inoculados com os isolados AM49 e AM61. O isolado AM49 produziu inflamação moderada no tecido cardíaco. Processo inflamatório discreto foi observado no tecido cardíaco de camundongos inoculados com os isolados AM28, AM38, AM61 e AM69. Processo inflamatório em músculo esquelético foi muito frequente. O exame do tecido cerebral revelou focos inflamatórios e gliose em camundongos inoculados com o i...

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Ocorrência de seis casos suspeitos, autóctones sorologicamente positivos ()

Cited by 22 publications

References 0 publications

Emerging Chagas Disease: Trophic Network and Cycle of Transmission ofTrypanosoma cruzifrom Palm Trees in the Amazon

Emerging Chagas Disease: Trophic Network and Cycle of Transmission ofTrypanosoma cruzifrom Palm Trees in the Amazon

Morbidade da doença de Chagas em pacientes autóctones da microrregião do Rio Negro, Estado do Amazonas

Biological behavior of Trypanosoma cruzi stocks obtained from the state of Amazonas, Western Brazilian Amazon, in mice

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