Emerging Chagas Disease: Trophic Network and Cycle of Transmission of<i>Trypanosoma cruzi</i>from Palm Trees in the Amazon

Teixeira, Antônio R. L.; Monteiro, Pedro Sadi; Rebêlo, José Manuel Macário; Argañaraz, Enrique R.; Vieira, Daniela; Lauria-Pires, Liana; Nascimento, Rubens J.; Vexenat, Cássia A.; Silva, Antonio R.; Ault, Steven K.; Costa, Jackson Maurício Lopes

doi:10.3201/eid0701.070100

Cited by 88 publications

(42 citation statements)

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“…Additionally, the genotype of the wild-type isolate was determined using the T. cruzi Berenice 188-nt digoxigenin-labelled probe, which identified anti-digoxigenin monoclonal antibody-labelled alkaline phosphatase (Molecular Probes). Colour detection was performed using the BCIP and NBT redox system to form a water-insoluble, dark blue precipitate (Teixeira et al 2001, Mendes et al 2007, Hecht et al 2010). …”

Section: Subjects Materials and Methodsmentioning

confidence: 99%

“…The ancient oral route, insect vector blood-borne infection, blood transfusion, organ transplantation, and accidental transmission in the hospital and research laboratories have contributed to the prevalence of exogenous infections in the human population (Teixeira et al 2001, Pérez-Molina et al 2012). Additionally, T. cruzi transmission from a mother to her offspring through the placenta is the only currently recognised endogenous source of infection.…”

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confidence: 99%

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Sexual transmission of American trypanosomiasis in humans: a new potential pandemic route for Chagas parasites

Araujo

Almeida

Pimentel

et al. 2017

Mem. Inst. Oswaldo Cruz

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BACKGROUND The Trypanosoma cruzi infection endemic in Latin America has now spread to several countries across four continents; this endemic involves triatomine vector-free protists. We hypothesised that the sexual transmission of T. cruzi contributes to the ongoing spread of Chagas disease.OBJECTIVES A short-term longitudinal study was conducted to evaluate this hypothesis.METHODS The study population comprised 109 subjects from four families, among whom 21 had been diagnosed with acute Chagas disease by direct parasitological analysis. Blood mononuclear cells and serum samples were obtained from each study subject once per year for three consecutive years. Enzyme-linked immunosorbent assay (ELISA) and indirect immunofluorescence serological examinations were used to detect specific T. cruzi antibodies. Polymerase chain reaction of T. cruzi DNA revealed 188-nucleotide bands, which hybridised to a specific radiolabelled probe and were confirmed by cloning and sequencing.RESULTS Three independent assessments at different time points revealed T. cruzi nuclear DNA footprints in 76% (83/109) of the study population with active infection. In contrast, the ELISA and indirect immunofluorescence assays detected the T. cruzi antibody in 28.4% (31/109) of the study samples. Moreover, the semen from 82.6% (19/23) of subjects people revealed harboured the 188- bp base pair T. cruzi footprint. Interestingly, the ejaculates of nuclear DNA-positive Chagas patient transmitted the T. cruzi upon peritoneal injection or infusion in the vagina of mice, and amastigotes were detected in the skeletal muscle, myocardium, vas deferens, and uterine tube.MAIN CONCLUSIONS T. cruzi infections can be transmitted from females or males to naïve mates through intercourse, and progeny showed discrepancies between the ratios of nuclear DNA footprints and specific antibody that can be explained by the tolerance attained during early embryo growth. Additional studies are needed to develop drugs to eradicate the infections. Additionally, the importance of a vigorous education, information, and communication program to prevent sexually transmitted Chagas disease in humans cannot be underemphasised.

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Section: Subjects Materials and Methodsmentioning

confidence: 99%

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confidence: 99%

Sexual transmission of American trypanosomiasis in humans: a new potential pandemic route for Chagas parasites

Araujo

Almeida

Pimentel

et al. 2017

Mem. Inst. Oswaldo Cruz

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“…Se han reportado 24 especies de los géneros Alberprosenia, Microtriatoma, Parabelminus, Pastrongylus, Triatoma, Eratyrus, Belminus y Rhodnius en diferentes especies de palmas (6,8,9); este último presenta alta infestación e infección con Trypanosoma cruzi y altas densidades, revelando un preocupante problema de salud pública (3).…”

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Comparación de métodos para la captura de triatominos (Hemiptera: Reduviidae) en palmas Attalea butyracea en los Llanos Orientales de Colombia

et al. 2013

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“…Control of Chagas was initially focused on rural areas, but massive rural–urban migration altered the epidemiology to make it both a rural and urban disease, with urban transmission occurring primarily via blood transfusion. Vector foci vary from housing structures, cleared or degraded land, and palm trees [42–44]. The relationship with LULC is particularly problematic as sylvatic foci of Chagas exist throughout Latin America [45], meaning that the distribution of T. cruzi will not only follow human–vector habitat, but also animal–vector habitat.…”

Section: Vector-borne Diseasesmentioning

confidence: 99%

Different ontologies: land change science and health research

Messina

Pan

2013

Current Opinion in Environmental Sustainability

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Land use and land cover (LULC) is now recognized as an important driver of disease. For emerging or re-emerging infectious diseases, LULC offers context and serves as a likely proximate driver of risk particularly when considering vector-borne or zoonotic diseases. Ontological differences embedded within disciplinary structures impede progress limiting the ultimate potential of both LULC data and land change theory within disease research. Geography, space, and time serve as effective complements to traditional health and place organizational and disease-research strategies. Improved systemic clarity is obtained if one orients the disease relationship to particular contexts and if the scales of the relationships are clearly defined.

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Emerging Chagas Disease: Trophic Network and Cycle of Transmission ofTrypanosoma cruzifrom Palm Trees in the Amazon

Cited by 88 publications

References 50 publications

Sexual transmission of American trypanosomiasis in humans: a new potential pandemic route for Chagas parasites

Sexual transmission of American trypanosomiasis in humans: a new potential pandemic route for Chagas parasites

Comparación de métodos para la captura de triatominos (Hemiptera: Reduviidae) en palmas Attalea butyracea en los Llanos Orientales de Colombia

Different ontologies: land change science and health research

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