Ocorrência de anticorpos e fatores de risco associados à infecção por Leptospira spp. em Cebus spp. mantidos em cativeiro no Nordeste do Brasil

Ferreira, Débora Rochelly Alves; Laroque, Plautino de Oliveira; Wagner, Paulo Guilherme Carniel; Higino, Severino Silvano dos Santos; Azevêdo, Sérgio Santos de; Rêgo, Eneida Willcox; Mota, Rinaldo Aparecido

doi:10.1590/s0100-736x2011001100014

Cited by 7 publications

(3 citation statements)

References 13 publications

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“…A similar study was carried out in Aracaju-Sergipe where it found positive primates for Leptospira, of the 18 primates analyzed 2 (11.1%) were positive for leptospirosis, and reports that shows the serovar Icterohaemorragiae is found in synatropic rodents as maintenance hosts, as well demonstrating that other species may have participated in the epidemiological chain of this sip (Pimentel et al, 2009). The rodents end up spreading the serovar through the urine and thus affecting other species of animals (Esteves, Neto, Girio, Vergara, & Carvalho, 2005;Murillo et al, 2020;Piredda et al, 2023), but another study shows that these rodents, as they are not a common part of this environment, can circulate at night and thus contaminate animals, which may explain its occurrence in the studied primates (Chuma et al, 2020;Ferreira et al, 2011;Rajeev et al, 2020). Among the studies carried out with primates using SAM as a diagnostic method, there is a study in the state of Tocantins in 2002 where a search for antibodies against Leptospira was carried out with 286 blood samples Cebus apella (capuchin monkey).…”

Section: Resultsmentioning

confidence: 90%

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Incidence of leptospirosis in non-human primates at the santarém zoo, Pará, Brazil

Camargo Junior,

Macedo,

Silva

et al. 2023

Acta Sci. Anim. Sci.

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Leptospirosis is an infectious disease that affects practically all domestic and wild animals, which can become carriers and, as a consequence, will contribute to the spread of the microorganism in nature. The present study aims to detect the occurrence of leptospirosis against by the microscopic serum agglutination test in animals at the Zoo of the Centro Universitário da Amazônia (ZOOUNAMA). 26 adult animals of both sexes and of the following species: 9 Sapajus apella, 2 Cebus kaapori, 3 Ateles marginatus, 10 Ateles paniscus, 1 Chiropetes satanas, 1 Allouata belzebul. Of the animals studied, 3 (11.5%) were reagents to be taken against Leptospira spp. The serovars found in the different species were: Icterohaemorragiae, Balum, Hardjo and Grippothyphosa. SAM proved to be efficient to detect against leptospira in non-human primates. Icterohaemorragiae type serum occurred with research results showing that it is also important in leptospirosis in non-human primates.

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Section: Resultsmentioning

confidence: 90%

“…In the Northeast region, the occurrence of antibodies against Leptospira in primates of the genus Cebus kept in captivity was studied, where 139 blood serum samples were analyzed using the SAM technique, with anti-Leptospira antibodies, serovar Patoc in 6.5% of primates (Ferreira et al, 2011;Oliveira & Santos, 2023).…”

Section: Resultsmentioning

confidence: 99%

Incidence of leptospirosis in non-human primates at the santarém zoo, Pará, Brazil

Camargo Junior,

Macedo,

Silva

et al. 2023

Acta Sci. Anim. Sci.

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“…Embora alguns sorovares considerados mais patogênicos tenham sido detectados em maior diluição, os animais encontravam-se assintomáticos no momento da colheita de material, situação semelhante à descrita anteriormente [11,16]. As razões pelas quais alguns pacientes apresentam manifestações clínicas graves e outros a sintomatologia é nula ou moderada, ainda são desconhecidas e podem estar ligadas não somente às características do agente, mas também a fatores relacionados ao hospedeiro como os genéti-cos, nutricionais e imunitários, por exposição prévia à Leptospira spp.…”

Section: Discussionunclassified

Role of Immunohistochemistry in the Diagnosis of Leptospirosis in Neotropical Primates

Grumann

Silva

Luz

et al. 2017

Acta Scientiae. Vet.

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Background: Leptospirosis is considered the most widespread zoonosis worldwide, occurring more frequently in tropical and developing regions. The aim of the present study was to detect the presence of Leptospira spp. in different primate tissues, using immunohistochemical (IHC) assays, taking advantage of the considerable number of necropsies compatible with a diagnosis of leptospirosis in neotropical primates at the Animal Pathology Laboratory (APL) of the University of Passo Fundo (UPF) in the northern region of Rio Grande do Sul. Materials, Methods & Results: Paraffin-embedded primate tissue samples were selected from necropsy examinations and subjected to IHC. The streptavidin-biotin-peroxidase method was used with diaminobenzidine chromogen (DAB) to verify immunostaining. Of the101 primates tested for Leptospira spp., 51.48% were positive; taining was distributed between lung (76.92%), liver (44.23%), and kidney (32.69%) tissue. Analysis of the combined anatomopathological verification data of the studied organs revealed a high frequency of lesions commonly observed in the tissues of animals exposed to the pathogen. For complementary diagnosis, an anti-Leptospira spp. antibody test was performed in primates at the UPF-Zoo, from which a population of the necropsied animals originated. The microscopic agglutination test (MAT) was utilized, which demonstrated 90.47% positivity in 21 individuals; sejroe and panama were the most frequent serovars. Discussion: Different intensities of tissue immunostaining were observed. Areas of fragmented or diffuse staining were considered to indicate equal positivity to that indicated by areas of staining with preserved morphology. Of 52 Leptospirapositive primates, most presented some degree of staining in lung samples, which shows a high level of involvement for this organ in primate leptospirosis. Conventional pathological diagnostic methods do not allow fort issue antigen recognition, thus making the IHC technique important to facilitate conclusive antigen sample verification. In the liver, leptospires were detected mostly between the sinusoids, hepatocytes, and Kupffer cells. In kidney tissues, staining indicated small agglomerates in the tubular lumen, interstitium, and glomeruli. All these forms of presentation have been previously reported. Considering that we detected the highest number of positive samples in lung tissue, followed by those from liver and kidney tissue, we argue that the IHC technique, when applied to samples of these three tissues, decreases the chance of false negatives. Anatomopathological studies of primate leptospirosis are scarce. In dogs, renal lesions are characterized by the necrosis and degeneration of tubular epithelium, cellular debris, and hyaline cylinders. In the liver, hepatocyte cord dissociation and biliary pigment accumulation within the canaliculi and hepatocellular necrosis are observed. These findings are similar to those from our study. In the lung, diffuse alveolar lesions are reported, with hemorrhage and edema, in add...

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Neotropical Primates and Humans: Risk of Bidirectional Parasite Transmission and Disease Sharing in Fragmented and Pristine Landscapes

Chaves,

del Carmen Villalobos-Segura,

Ayala

et al. 2024

Ecology of Wildlife Diseases in the Neotropics

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Ocorrência de anticorpos e fatores de risco associados à infecção por Leptospira spp. em Cebus spp. mantidos em cativeiro no Nordeste do Brasil

Cited by 7 publications

References 13 publications

Incidence of leptospirosis in non-human primates at the santarém zoo, Pará, Brazil

Incidence of leptospirosis in non-human primates at the santarém zoo, Pará, Brazil

Role of Immunohistochemistry in the Diagnosis of Leptospirosis in Neotropical Primates

Neotropical Primates and Humans: Risk of Bidirectional Parasite Transmission and Disease Sharing in Fragmented and Pristine Landscapes

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