Ocimum sanctum Linn. as a natural source of skin anti-ageing compounds

Chaiyana, Wantida; Anuchapreeda, Songyot; Punyoyai, Chanun; Neimkhum, Waranya; Lee, Kuan‐Han; Lin, Wen‐Tai; Lue, Shang-Chian; Viernstein, Helmut; Mueller, Monika

doi:10.1016/j.indcrop.2018.10.081

Cited by 62 publications

(78 citation statements)

References 30 publications

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“…Collagen fibrils, the major protein of the extracellular matrix (ECM) in dermis which strengthen the skin, can be hydrolyzed by collagenase (MMPs) and lead to skin ageing [23,47]. Similarly, elastin fibrils are other ECM components that play an important role in skin elasticity, and the cleavage of elastin fibrils by elastase leads to sagging and wrinkling skin [23,48]. Moreover, hyaluronic acid, which is a naturally occurring polysaccharide in the skin, can easily be digested by hyaluronidase and lead to the loss of skin moisture, resulting in wrinkled skin [49].…”

Section: Anti-skin-ageing Activities Of O Vulgare Essential Oilsmentioning

confidence: 99%

Chemical Compositions and Anti-Skin-Ageing Activities of Origanum vulgare L. Essential Oil from Tropical and Mediterranean Region

2020

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Origanum vulgare L. has been used as a culinary ingredient worldwide. This study revealed the cosmeceutical potential of O. vulgare essential oil as a skin-ageing retardant. The O. vulgare essential oil from a highland area of a tropical country (HO), obtained by hydrodistillation was investigated and compared to a commercial oil from the Mediterranean region (CO). Their chemical compositions were investigated by gas chromatography–mass spectrometry. Antioxidant activities were investigated by ferric reducing antioxidant power, 1,1-diphenyl-2-picrylhydrazyl, and ferric thiocyanate assay. Anti-skin-ageing activities were determined by means of collagenase, elastase, and hyaluronidase inhibition. Carvacrol was the major component in both oils, but a higher amount was detected in HO (79.5%) than CO (64.6%). HO possessed comparable radical scavenging activity to CO (IC50 = 1.8 ± 0.8 mg/mL) but significantly higher lipid peroxidation inhibition (38.0 ± 0.8%). Carvacrol was remarked as the major compound responsible for the reducing power of both oils. Interestingly, HO possessed significant superior anti-skin-ageing activity than ascorbic acid (P < 0.01), with inhibition against collagenase, elastase, and hyaluronidase of 92.0 ± 9.7%, 53.1 ± 13.3%, and 16.7 ± 0.3%, at the concentration of 67, 25, and 4 µg/mL, respectively. Since HO possessed comparable anti-hyaluronidase activity to CO and superior anti-collagenase and anti-elastase (P < 0.01), HO was suggested to be used as a natural skin-ageing retardant in a cosmetic industry.

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Section: Anti-skin-ageing Activities Of O Vulgare Essential Oilsmentioning

confidence: 99%

Chemical Compositions and Anti-Skin-Ageing Activities of Origanum vulgare L. Essential Oil from Tropical and Mediterranean Region

2020

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“…The different concentrations of extracts and standard dissolved in dimethyl sulfoxide (DMSO) were mixed with 167 µM DPPH • in methanol and incubated in the dark at room temperature for 30 min [7]. Then, the mixtures were measured at 520 nm using a microplate reader (SPECTROstar Nano ® , Ortenberg, Germany).…”

Section: Dpph Radical Scavenging Assaymentioning

confidence: 99%

“…The levels of MMP-2 and -9 expression were investigated using SDS-PAGE [7]. The secretions of MMP-2 and -9 in the culture medium from 3T3 cell were treated with various concentrations of the extracts at 37 • C in a humidified atmosphere containing 5% v/v CO 2 .…”

Section: Mmp-2 and -9 Determination By Sodium Dodecyl Sulfate-polyacrmentioning

confidence: 99%

“…T. laurifolia leaf extracts were investigated for hyaluronidase inhibitory activity using gel electrophoresis [7]. The samples were mixed with hyaluronidase from bovine testis and incubated at 37 • C. The incubated mixtures were collected after 48 h and mixed with an equal volume of the bromophenol blue dye solution.…”

Section: Determination Of Hyaluronidase Inhibition By Gel Electrophormentioning

confidence: 99%

“…However, hyaluronic acid is gradually degraded by the enzyme hyaluronidase. Since hyaluronidase is the key factor that controls the turnover of hyaluronic acid in human skin [7], inhibition of hyaluronidase activity retards hyaluronic acid destruction and leads to retention of skin moisture.…”

Section: Introductionmentioning

confidence: 99%

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Chemical Constituents, Antioxidant, Anti-MMPs, and Anti-Hyaluronidase Activities of Thunbergia laurifolia Lindl. Leaf Extracts for Skin Aging and Skin Damage Prevention

et al. 2020

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This study aimed to investigate the potential usage of Thunbergia laurifolia Lindl. leaf extracts in the cosmetic industry. Matrix metalloproteinases (MMPs) and hyaluronidase inhibition of T. laurifolia leaf extracts, prepared using reflux extraction with deionized water (RE) and 80% v/v ethanol using Soxhlet's apparatus (SE), were determined. Rosmarinic acid, phenolics, and flavonoids contents were determined using high-performance liquid chromatography, Folin-Ciocalteu, and aluminum chloride colorimetric assays, respectively. Antioxidant activities were determined by 1,1-diphenyl-2-picrylhydrazyl (DPPH) and linoleic acid-thiocyanate assays. MMP-1 inhibition was investigated using enzymatic and fluorescent reactions, whereas MMP-2, MMP-9, and hyaluronidase inhibition were investigated using gel electrophoresis. Cytotoxicity on human fibroblast cell line was also investigated. The results demonstrated that SE contained significantly higher content of rosmarinic acid (5.62% ± 0.01%) and flavonoids (417 ± 25 mg of quercetin/g of extract) but RE contained a significantly higher phenolics content (181 ± 1 mg of gallic acid/g of extract; p < 0.001). SE possessed higher lipid peroxidation inhibition but less DPPH • scavenging activity than RE. Both extracts possessed comparable hyaluronidase inhibition. SE was as potent an MMP-1 inhibitor as gallic acid (half maximal inhibitory concentration values were 12.0 ± 0.3 and 8.9 ± 0.4 mg/cm 3 , respectively). SE showed significantly higher MMP-2 and MMP-9 inhibition than RE (p < 0.05). Therefore, SE is a promising natural anti-ageing ingredient rich in rosmarinic acid and flavonoids with antioxidant, anti-hyaluronidase, and potent MMPs inhibitory effects that could be applied in the cosmetic industry.

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Skincare Finishes to Textiles

Danila

Chirila

2021

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Ocimum sanctum Linn. as a natural source of skin anti-ageing compounds

Cited by 62 publications

References 30 publications

Chemical Compositions and Anti-Skin-Ageing Activities of Origanum vulgare L. Essential Oil from Tropical and Mediterranean Region

Chemical Compositions and Anti-Skin-Ageing Activities of Origanum vulgare L. Essential Oil from Tropical and Mediterranean Region

Chemical Constituents, Antioxidant, Anti-MMPs, and Anti-Hyaluronidase Activities of Thunbergia laurifolia Lindl. Leaf Extracts for Skin Aging and Skin Damage Prevention

Skincare Finishes to Textiles

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