OCIAD2 activates γ-secretase to enhance amyloid β production by interacting with nicastrin

Han, Jonghee; Jung, Sunmin; Jang, Jiyeon; Kam, Tae In; Choi, Hyunwoo; Kim, Byung Ju; Nah, Jihoon; Jo, Dong Gyu; Nakagawa, Toshiyuki; Nakagawa, Masaki; Jung, Yong Keun

doi:10.1007/s00018-013-1515-x

Cited by 21 publications

(35 citation statements)

References 51 publications

(66 reference statements)

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“…Based on our preliminary data analysis through COMPARTMENTS database (http://compartments.jensenlab.org), OCIAD2 is thought to be localized in mitochondria. In addition, Han et al have reported that OCIAD2 is localized in the mitochondria of HeLa cell . Therefore, we hypothesized that OCIAD2 is localized in mitochondria and examined the intracellular localization of OCIAD2 in lung adenocarcinoma.…”

Section: Resultsmentioning

confidence: 92%

“…In addition, Han et al have reported that OCIAD2 is localized in the mitochondria of HeLa cell. 22 Therefore, we hypothesized that OCIAD2 is localized in mitochondria and examined the intracellular localization of OCIAD2 in lung adenocarcinoma. We carried out immunofluorescence cytochemistry of A549 cells using a mitochondrial marker, VDAC1.…”

Section: Intracellular Localization Of Ociad2 In Tumor Cellsmentioning

confidence: 99%

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High expression of ovarian cancer immunoreactive antigen domain containing 2 (OCIAD2) is associated with poor prognosis in lung adenocarcinoma

Sakashita

Murata

et al. 2018

Pathology International

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The clinicopathological implications of ovarian cancer immunoreactive antigen domain containing 2 (OCIAD2) in lung adenocarcinoma were investigated. The expression of OCIAD2 in 191 surgically resected lung adenocarcinomas was examined using immunohistochemistry. OCIAD2 expression was quantified using the H‐score and dichotomized as high or low. High OCIAD2 protein expression was significantly correlated with vascular invasion (P = 0.0018), lymphatic permeation (P = 0.049), T factor (P = 0.0024), and pathological stage (P = 0.0003). High OCIAD2 expression was significantly associated with poorer overall survival (OS) (n = 191, P = 0.0325). In peripheral‐type lung adenocarcinomas (n = 161), high OCIAD2 expression was significantly associated with both poorer OS (P = 0.0214) and poorer disease‐free survival (P = 0.0496). Adenocarcinoma in situ (AIS) and minimally invasive adenocarcinoma (MIA) showed weaker OCIAD2 expression than invasive adenocarcinoma. Among small adenocarcinomas measuring 2 cm or less in greatest dimension classified according to the Noguchi's classification (n = 79), invasive adenocarcinomas showed significantly higher OCIAD2 expression than non‐invasive adenocarcinomas (P = 0.0007). Interestingly, OCIAD2 was expressed heterogeneously even within a tumor, and its expression was higher in areas of invasion than in areas of in situ spread. Our results suggest that OCIAD2 could be a useful prognostic biomarker of lung adenocarcinoma.

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Section: Resultsmentioning

confidence: 92%

Section: Intracellular Localization Of Ociad2 In Tumor Cellsmentioning

confidence: 99%

High expression of ovarian cancer immunoreactive antigen domain containing 2 (OCIAD2) is associated with poor prognosis in lung adenocarcinoma

Sakashita

Murata

et al. 2018

Pathology International

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“…Therefore, analysis of DNA methylation in bronchial washing specimens may represent a new approach for the detection of cancer cells in such specimens. Although the function of OCIAD2 is still unclear, it is located mainly in mitochondria and mitochondria‐associated ER membranes (MAM) . At the same time, OCIAD2 has high homology with OCIAD1, which was originally immunoscreened from ascites of a patient with ovarian cancer.…”

Section: Discussionmentioning

confidence: 99%

Immunocytochemical staining for stratifin and OCIAD2 in bronchial washing specimens increases sensitivity for diagnosis of lung cancer

et al. 2014

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“…Interestingly, TRNP1 has recently been discovered as a DNA-binding protein with essential modulating functions during tangential and radial migration of neuroblasts within the developing cerebral cortex (Stahl et al, 2013), corroborating the identification of distinct origin-dependent identities in fNSC-iPSC-NPCs. Other genes were equally downregulated in fNSCs and fNSC-iPSC-NPCs and included OCIAD2, a g-secretase-activating gene highly expressed in patients with Alzheimer's disease (Han et al, 2014), and CD70, a nonneural surface molecule on T and B lymphocytes (Borst et al, 2005). In line with the observation of origin-dependent identities in iPSC-derived NPCs, we identified a significantly smaller number of genes that were exclusively expressed at similar levels in fNSCs and mesodermal NPCs (LOC339535 in CD34-iPSC-NPCs and ZP3, POMZP3, VAV3 and VGF3 in FibiPSC-NPCs) and for which, except for VGF3, neural functions have not been described.…”

Section: Identification Of Origin-dependent Cell Identities In Human mentioning

confidence: 99%

Origin-Dependent Neural Cell Identities in Differentiated Human iPSCs In Vitro and after Transplantation into the Mouse Brain

et al. 2014

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The differentiation capability of induced pluripotent stem cells (iPSCs) toward certain cell types for disease modeling and drug screening assays might be influenced by their somatic cell of origin. Here, we have compared the neural induction of human iPSCs generated from fetal neural stem cells (fNSCs), dermal fibroblasts, or cord blood CD34(+) hematopoietic progenitor cells. Neural progenitor cells (NPCs) and neurons could be generated at similar efficiencies from all iPSCs. Transcriptomics analysis of the whole genome and of neural genes revealed a separation of neuroectoderm-derived iPSC-NPCs from mesoderm-derived iPSC-NPCs. Furthermore, we found genes that were similarly expressed in fNSCs and neuroectoderm, but not in mesoderm-derived iPSC-NPCs. Notably, these neural signatures were retained after transplantation into the cortex of mice and paralleled with increased survival of neuroectoderm-derived cells in vivo. These results indicate distinct origin-dependent neural cell identities in differentiated human iPSCs both in vitro and in vivo.

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OCIAD2 activates γ-secretase to enhance amyloid β production by interacting with nicastrin

Cited by 21 publications

References 51 publications

High expression of ovarian cancer immunoreactive antigen domain containing 2 (OCIAD2) is associated with poor prognosis in lung adenocarcinoma

High expression of ovarian cancer immunoreactive antigen domain containing 2 (OCIAD2) is associated with poor prognosis in lung adenocarcinoma

Immunocytochemical staining for stratifin and OCIAD2 in bronchial washing specimens increases sensitivity for diagnosis of lung cancer

Origin-Dependent Neural Cell Identities in Differentiated Human iPSCs In Vitro and after Transplantation into the Mouse Brain

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