Ochrobactrum anthropi bacteremia in a preterm infant with cystic fibrosis

Menezes, Fernando Gatti de; Abreu, Maria Gabriela Ballalai; Kawagoe, Julia Yaeko; Warth, Arno Norberto; Deutsch, Alice D’Agostini; Dornaus, Maria Fernanda P S; Martino, Marinês Dalla Valle; Corrêa, Luci

doi:10.1590/s1517-83822014005000043

Cited by 12 publications

(8 citation statements)

References 11 publications

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“…The distribution of (pro)phages (represented by nodes) in the network allows for more precise insight into Ochrobactrum (pro)phages diversity. It was shown that 198 (70.5%) Ochrobactrum (pro)phages shared similarity to the phages infecting other Proteobacteria (223 (pro)phages in the network), which is representatives of the Terrabacteria group (54) or of phages recovered from the metagenomic samples for which hosts were not assigned (17). Amongst the Proteobacteria (pro)phages grouped together with Ochrobactrum phages, 89 viruses infected Alphaproteobacteria, 15 Betaproteobacteria, and 115 Gammaproteobacteria.…”

Section: Host Range Analysismentioning

confidence: 99%

“…In these cases, bacteria are isolated mostly from immunocompromised patients, as pathogens colonizing respiratory tract and wounds. These are mostly opportunistic infections, including central venous catheter-associated bloodstream infections, prosthetic valve endocarditis, septic arthritis, osteomyelitis, and peritonitis [16][17][18][19][20]. Hence, to prevent using pathogenic or multi-resistant strains, the application of Ochrobactrum spp.…”

Section: Introductionmentioning

confidence: 99%

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Identification and Characterization of the First Virulent Phages, Including a Novel Jumbo Virus, Infecting Ochrobactrum spp.

Decewicz

Golec

Szymczak

et al. 2020

IJMS

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The Ochrobactrum genus consists of an extensive repertoire of biotechnologically valuable bacterial strains but also opportunistic pathogens. In our previous study, a novel strain, Ochrobactrum sp. POC9, which enhances biogas production in wastewater treatment plants (WWTPs) was identified and thoroughly characterized. Despite an insightful analysis of that bacterium, its susceptibility to bacteriophages present in WWTPs has not been evaluated. Using raw sewage sample from WWTP and applying the enrichment method, two virulent phages, vB_OspM_OC and vB_OspP_OH, which infect the POC9 strain, were isolated. These are the first virulent phages infecting Ochrobactrum spp. identified so far. Both phages were subjected to thorough functional and genomic analyses, which allowed classification of the vB_OspM_OC virus as a novel jumbo phage, with a genome size of over 227 kb. This phage encodes DNA methyltransferase, which mimics the specificity of cell cycle regulated CcrM methylase, a component of the epigenetic regulatory circuits in Alphaproteobacteria. In this study, an analysis of the overall diversity of Ochrobactrum-specific (pro)phages retrieved from databases and extracted in silico from bacterial genomes was also performed. Complex genome mining allowed us to build similarity networks to compare 281 Ochrobactrum-specific viruses. Analyses of the obtained networks revealed a high diversity of Ochrobactrum phages and their dissimilarity to the viruses infecting other bacteria.

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Section: Host Range Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Identification and Characterization of the First Virulent Phages, Including a Novel Jumbo Virus, Infecting Ochrobactrum spp.

Decewicz

Golec

Szymczak

et al. 2020

IJMS

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“…sociated with the presence of central device. The identification of the microorganism was initially by automated method (BATEC system), with subsequent use of MALDI-TOF, PCR, and genetic sequencing of 16S ribosomal RNA [16].…”

Section: Discussionmentioning

confidence: 99%

Identification of Ochrobactrum oryzae in Bloodstream Primary Infection in a Dialysis Patient: Can it be an Emerging Pathogen?

Borges¹

2016

Journal of Microbiology and Infectious Diseases

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“…Ochrobactrum anthropi is an emerging opportunistic pathogen [ 1 , 2 ] that has typically been associated with bacteremia and sepsis in immunocompromised patients and in patients with indwelling medical devices [ 3 , 4 ]. However, with improved speciation techniques, O. anthropi has now been implicated in a broad range of infections, even in immunocompetent hosts.…”

Section: Introductionmentioning

confidence: 99%

Ochrobactrum anthropiKeratitis with Focal Descemet’s Membrane Detachment and Intracorneal Hypopyon

Venkateswaran

Wozniak

Hindman

2016

Case Reports in Ophthalmological Medicine

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Purpose. To describe a unique case of O. anthropi keratitis associated with a rare manifestation of Descemet's membrane detachment and intracorneal hypopyon and to discuss challenges in diagnosis and management. Methods. Best-corrected visual acuity was measured with Snellen letters. Corneal scrapings were performed and aerobic, viral, herpetic, acid-fast bacilli, Acanthamoeba, and fungal stains and cultures were obtained. Following evisceration, tissue was evaluated for histologic features and again stained for bacteria, mycobacteria, Acanthamoeba, fungi, and viral particles. Results. Initial presentation to our institute was notable for a corneal ulcer, focal Descemet's membrane detachment, and intracorneal hypopyon. Speciation of initial corneal scrapes revealed Ochrobactrum anthropi and initial management included fortified tobramycin. Despite medical therapy, the patient developed a corneal perforation and required subsequent evisceration. Conclusion. O. anthropi is an emerging ocular pathogen that has not been previously reported in cases of keratitis. As this pathogen becomes increasingly recognized as a source of ocular infections, it is important to identify and treat aggressively to avoid vision-threatening disease.

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Ochrobactrum anthropi bacteremia in a preterm infant with cystic fibrosis

Cited by 12 publications

References 11 publications

Identification and Characterization of the First Virulent Phages, Including a Novel Jumbo Virus, Infecting Ochrobactrum spp.

Identification and Characterization of the First Virulent Phages, Including a Novel Jumbo Virus, Infecting Ochrobactrum spp.

Identification of Ochrobactrum oryzae in Bloodstream Primary Infection in a Dialysis Patient: Can it be an Emerging Pathogen?

Ochrobactrum anthropiKeratitis with Focal Descemet’s Membrane Detachment and Intracorneal Hypopyon

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