Ochrobactrum anthropiKeratitis with Focal Descemet’s Membrane Detachment and Intracorneal Hypopyon

Abstract

Purpose. To describe a unique case of O. anthropi keratitis associated with a rare manifestation of Descemet's membrane detachment and intracorneal hypopyon and to discuss challenges in diagnosis and management. Methods. Best-corrected visual acuity was measured with Snellen letters. Corneal scrapings were performed and aerobic, viral, herpetic, acid-fast bacilli, Acanthamoeba, and fungal stains and cultures were obtained. Following evisceration, tissue was evaluated for histologic features and again stained for bacteria, mycobacteria, Acanthamoeba, fungi, and viral particles. Results. Initial presentation to our institute was notable for a corneal ulcer, focal Descemet's membrane detachment, and intracorneal hypopyon. Speciation of initial corneal scrapes revealed Ochrobactrum anthropi and initial management included fortified tobramycin. Despite medical therapy, the patient developed a corneal perforation and required subsequent evisceration. Conclusion. O. anthropi is an emerging ocular pathogen that has not been previously reported in cases of keratitis. As this pathogen becomes increasingly recognized as a source of ocular infections, it is important to identify and treat aggressively to avoid vision-threatening disease.

Genomics-Based Identification of Microorganisms in Human Ocular Body Fluid

“…We also detected Toxoplasma gondii as the most abundant organism in this specimen (represented by 4,410 reads), but did only detect 4 reads for Hammondia hammondi ; most likely because we had removed DNA sequences from the Hammondia hammondi genome in the database that were flagged as ambiguous. In addition, in subject 5 we detected Ochrobactrum anthropi , an agent that had been identified previously in eye infections such as endophthalmitis and keratitis 20 , 21 . However, we detected Ochrobactrum anthropi in high abundance in the water control sample and therefore it may here rather represent an environmental contaminant.…”

Comparison of Culture Results between Specimens from Corneal Scraping with Microhomogenization and Corneal Swab in Moderate and Severe Bacterial Corneal Ulcers

“…Ochrobactrum anthropi belongs to the group of Gram-negative rods that have been reported as a cause of corneal ulcers and are aggressive in immunocompromised patients. 15 This bacterium has also been reported as a cause of endophthalmitis.…”

Ochrobactrum anthropi infection following corneal transplantation -A Case Report and Review of Literature

“…Ochrobactrum anthropi, being an opportunistic pathogen, manifests infection signi cantly in individuals with compromised immune function and a history of both local and systemic antibiotic usage [8] [34], [35], [36], [37]. However, in this particular case, the patient did not employ any indwelling or invasive medical devices, and comprehensive examinations, both physical and systemic, failed to reveal any symptoms.…”