Ochratoxin A in blood and its pharmacokinetic properties

Fuchs, Radovan; Hult, Karl

doi:10.1016/0278-6915(92)90034-i

Cited by 55 publications

(47 citation statements)

References 17 publications

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“…OTA was shown to bind to serum albumin and to a yet unidentified 20 kDa rat serum protein with high affinity (Stojkovic et al, 1984;Hagelberg et al, 1989;Fuchs and Hult, 1992), and that the largest amounts of OTA found in the kidney accumulated in the proximal tubules, where kidney lesions appear to be predominantly located (Elling, 1977;Lee et al, 1984;Fuchs, 1988;Breitholz-Emanuelsson et al, 1991;Fuchs and Hult, 1992). Therefore the question was asked whether OTA binding to h2u and subsequently increased cell proliferation could exacerbate the tumorigenic response in male rats and thus be responsible for the higher tumor incidence observed in male than in female rats.…”

Section: Introductionmentioning

confidence: 99%

The role of α2u-globulin in ochratoxin A induced renal toxicity and tumors in F344 rats

1999

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The mycotoxin ochratoxin A (OTA) was shown to be a potent kidney carcinogen in rats demonstrating a marked sex difference in the response. Compared to female rats, male rats had a 10-fold higher incidence of kidney carcinomas. The objective of this study was to investigate whether this sex difference in tumor response is due to an exacerbation of effect resulting from the interaction of the male rat specific urinary protein h2u-globulin (h2u) with OTA. Male and female rats were treated by oral gavage with OTA (1 mg/kg per day), D-limonene (dL; 1650 mg/kg per day) as a positive control or corn oil for 7 consecutive days. OTA induced severe renal lesions predominantly in the P 3 region of the proximal tubules. The lesions consisted of necrotic cells and cell exfoliations. No hyaline droplets were found in the P 2 segment following OTA treatment, whereas dL induced the expected accumulation of droplets. The results suggest that OTA induced kidney lesions are in all characteristic points different from the known h2u-nephropathy induced by dL. Based on these experiments the male rat specific protein h2u does not seem to be involved in the mechanism(s) leading to the high tumor incidence observed in OTA exposed male rats.

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Section: Introductionmentioning

confidence: 99%

The role of α2u-globulin in ochratoxin A induced renal toxicity and tumors in F344 rats

1999

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“…Enterohepatic circulation of OTA has been demonstrated in several studies with rats (Fuchs and Hult, 1992;Kane et al, 1986;Kumagai and Aibara, 1982). This means that OTA or OTA-metabolites are secreted into bile which is excreted into duodenum via the common bile duct.…”

Section: Excretionmentioning

confidence: 99%

“…Fuchs and Hult (1992) stated that differences in effectiveness of enterohepatic circulation of OTA among animal species might be partially responsible for the differences in the retention of the toxin in plasma among the species.…”

Section: Excretionmentioning

confidence: 99%

Ochratoxin A kinetics: A review of analytical methods and studies in rat model

Vettorazzi

González-Peñas

Ceráin

2014

Food and Chemical Toxicology

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Ochratoxin A (OTA) is a thermostable mycotoxin that contaminates a great variety of foodstuffs. It is nephrotoxic in all of the mammalian species tested, being the pig the most sensitive one; among rodents, rats are the most susceptible to OTA carcinogenicity. Kinetics, by studying the absorption, distribution, metabolism and excretion of xenobiotics, is an important tool for the extrapolation of animal toxicity data. The most important kinetic studies performed with OTA in rats have been reviewed, together with the different methods used for OTA quantification in biological matrices. Thirteen studies in Wistar, Sprague-Dawley or F344 rats, using radiolabeled OTA or TLC, HPLC-FLD or HPLC-MS have been summarized. Very often methods validated for food have been directly applied to tissues. Strain, sex and age differences have been detected but the interpretation is difficult due to the different experimental conditions, and the connection of the several factors that may account for these differences.

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“…Esta ligação prolonga o tempo de meia vida da OTA no organismo. Uma grande fração da OTA sofre excreção biliar seguida de reabsorção da toxina pelo intestino e reabsorção pelos túbulos renais, retornando à circulação sanguínea e favorecendo sua redistribuição a diferentes tecidos (FUCHS;HULTA, 1992). A reabsorção nos túbulos proximal e distal causa acumulação de OTA nos tecidos renais, resultando na alta susceptibilidade do rim aos danos causados por OTA (DUARTE; LINO; PENA, 2011).…”

Section: Mecanismo De Açãounclassified

Impacto das Fumonisinas, Aflatoxinas e Ocratoxina A na Avicultura

Bordini¹,

Rossi²,

Hirooka³

et al. 2013

BBR

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Brazil is the third largest producer of poultry in the world and the leading exporter. However, mycotoxin contamination in corn and feed can cause serious economic losses to the poultry industry. Mycotoxins have been linked to several poultry diseases and, when metabolized may occur in meat and eggs and are an additional source for human contamination. Therefore, continuous monitoring of mycotoxin levels in the feed producing chain is essential to increase productivity, ensure poultry product quality and minimize human health hazards. The aim of this study was to revise the main aspects of mycotoxins (fumonisin, aflatoxins and ochratoxin A), including the producing fungi, the biosynthesis pathway, the toxicological effects in poultry and occurrence in corn and poultry feed Keywords: fumonisins, aflatoxins, ochratoxin A, chicken, corn RESUMOO Brasil é o terceiro produtor mundial de aves e o líder em exportações. No entanto, a contaminação de milho e rações por micotoxinas pode acarretar grandes perdas econômicas à avicultura. As micotoxinas estão associadas a diversos efeitos tóxicos em aves e, ao serem metabolizadas, podem ocorrer em carne e ovos, constituindo um risco para a saúde humana. Portanto, o monitoramento contínuo de micotoxinas na cadeia produtiva de rações é essencial para aumentar a produtividade, assegurar a qualidade do produto e minimizar os riscos à saúde humana. Este estudo teve como objetivo revisar os principais aspectos das micotoxinas (fumonisinas, aflatoxinas e ocratoxina A), incluindo os fungos produtores, via de biossíntese, efeitos toxicológicos em aves e a ocorrência em milho e rações de aves.Palavras-chave: fumonisinas, aflatoxinas, ocratoxina A, aves, rações BBR -Biochemistry and Biotechnology Reports

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Ochratoxin A in blood and its pharmacokinetic properties

Cited by 55 publications

References 17 publications

The role of α2u-globulin in ochratoxin A induced renal toxicity and tumors in F344 rats

The role of α2u-globulin in ochratoxin A induced renal toxicity and tumors in F344 rats

Ochratoxin A kinetics: A review of analytical methods and studies in rat model

Impacto das Fumonisinas, Aflatoxinas e Ocratoxina A na Avicultura

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