Ocean acidification increases cadmium accumulation in marine bivalves: a potential threat to seafood safety

Shi, Wei; Zhao, Xinguo; Han, Yu; Che, Zhumei; Chai, Xueliang; Liu, Guangxu

doi:10.1038/srep20197

Cited by 102 publications

(49 citation statements)

References 49 publications

(55 reference statements)

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“…Thus, these mechanisms may explain why, in the present study, organisms accumulated more As at low pH. Similar effects were also observed in marine bivalves C. virginica, Mercenaria mercenaria, M. edulis, Tegillarca granosa, and Meretrix meretrix exposed to Cu and Cd, and low pH levels (7.40-7.6) (Götze et al, 2014;Shi et al, 2016) (Table 3).…”

Section: Arsenic Accumulation and Bcf Valuessupporting

confidence: 84%

The impacts of As accumulation under different pH levels: Comparing Ruditapes decussatus and Ruditapes philippinarum biochemical performance

Velez

Figueira

Soares

et al. 2016

Environmental Research

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Marine bivalves have been used to assess environmental As contamination and the effects of seawater acidification when both factors are acting alone, but limited information is available regarding the impacts of both factors acting in combination. The aim of this study was to compare physiological (glycogen) and biochemical (lipid peroxidation, superoxide dismutase, catalase, glutathione-S-transferase and alkaline phosphatase) responses in both native (Ruditapes decussatus) and introduced (R. philippinarum) clams, when exposed to the combined effects of pH (7.8, control; 7.3) and As concentrations (0 and 4mg/L). The combined effect of As and pH on the health risks associated with clam consumption was also analyzed. Results revealed that both species were able to accumulate As under both pH levels, although higher As concentrations where observed under low pH. Thus, predicted pH decrease will potentiate health risks associated with the consumption of such species, since less amount of clams exposed to As is needed for an adult to exceed the provisional tolerable weekly intake (PTWI). Low pH, As exposure and the combination of both factors did not negatively affect the native species, since clams were able to maintain their physiological and biochemical performance among all conditions. On the other hand, R. philippinarum was negatively affected by As exposure at control pH (7.8), inducing biotransformation and antioxidant defense mechanisms against As toxicity. R. philippinarum exposed and non-exposed to As presented similar responses under low pH although at this condition the introduced species accumulated twice the amount of As than R. decussatus.

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Section: Arsenic Accumulation and Bcf Valuessupporting

confidence: 84%

The impacts of As accumulation under different pH levels: Comparing Ruditapes decussatus and Ruditapes philippinarum biochemical performance

Velez

Figueira

Soares

et al. 2016

Environmental Research

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“…Bivalves accumulate heavy metals slowly throughout their life, and their elimination is tremendously slow when treated only with clean seawater [58]. The heaviest heavy metal traditionally known to be dangerous to human health is Hg 2+ , with greater importance in pregnant women and children [59,60]. However, other targets, such as Cd 2+ , also represent an important risk, as a consequence of their solubility and because they are capable of producing problems in the immune and reproductive systems and have a potentially teratogenic effect [61].…”

Section: Depuration By Chemical Methodsmentioning

confidence: 99%

Complementary Methods to Improve the Depuration of Bivalves: A Review

Martinez-Albores

López-Santamarina

Rodríguez

et al. 2020

Foods

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Bivalves are filter feeders that can accumulate and concentrate waterborne contaminants present in the water in which they live. Biotoxins, pathogenic bacteria, viruses, and heavy metals present in the aquaculture environment constitute the main hazards for human health. The most common method employed for combating waterborne pollutants in bivalves is depuration with purified seawater. Although this method is effective at increasing the microbiological quality of bivalves, in most cases, it is ineffective at eliminating other risks, such as, for example, viruses or heavy metals. Biological (bacteriocins and bacteriophages), physical (UV light, ozone, and gamma-irradiation), chemical (metallothioneins and chitosan), and other industrial processing methods have been found to be useful for eliminating some contaminants from seawater. The aim of this work was to provide a review of academic articles concerning the use of treatments complementary to conventional depuration, aiming to improve depuration process efficiency by reducing depuration times and decreasing the levels of the most difficult-to-erase contaminants. We conclude that there are different lab-tested strategies that can reduce depuration times and increase the food safety of bivalve produce, with possible short- and long-term industrial applications that could improve the competitivity of the aquaculture industry.

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“…The development and industrialization of coastal zones has contributed greatly to Cd pollution in marine environments 4 . As a result, Cd is one of seven most common released heavy metals for the environment (Cd, Cr, Cu, Hg, Ni, Pb, and Zn) 5 and affects many invertebrates in marine, such as gastropod mollusks and bivalve 6 . In the East China Sea, especially along the coasts in Zhejiang Province, Cd has been determined as the most abundant heavy-metal pollutant in Tegillarca granosa 7 .…”

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confidence: 99%

Identification of a regulation network in response to cadmium toxicity using blood clam Tegillarca granosa as model

Bao

Liu

Zhang

et al. 2016

Sci Rep

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Clam, a filter-feeding lamellibranch mollusk, is capable to accumulate high levels of trace metals and has therefore become a model for investigation the mechanism of heavy metal toxification. In this study, the effects of cadmium were characterized in the gills of Tegillarca granosa during a 96-hour exposure course using integrated metabolomic and proteomic approaches. Neurotoxicity and disturbances in energy metabolism were implicated according to the metabolic responses after Cd exposure, and eventually affected the osmotic function of gill tissue. Proteomic analysis showed that oxidative stress, calcium-binding and sulfur-compound metabolism proteins were key factors responding to Cd challenge. A knowledge-based network regulation model was constructed with both metabolic and proteomic data. The model suggests that Cd stimulation mainly inhibits a core regulation network that is associated with histone function, ribosome processing and tight junctions, with the hub proteins actin, gamma 1 and Calmodulin 1. Moreover, myosin complex inhibition causes abnormal tight junctions and is linked to the irregular synthesis of amino acids. For the first time, this study provides insight into the proteomic and metabolomic changes caused by Cd in the blood clam T. granosa and suggests a potential toxicological pathway for Cd.

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Ocean acidification increases cadmium accumulation in marine bivalves: a potential threat to seafood safety

Cited by 102 publications

References 49 publications

The impacts of As accumulation under different pH levels: Comparing Ruditapes decussatus and Ruditapes philippinarum biochemical performance

The impacts of As accumulation under different pH levels: Comparing Ruditapes decussatus and Ruditapes philippinarum biochemical performance

Complementary Methods to Improve the Depuration of Bivalves: A Review

Identification of a regulation network in response to cadmium toxicity using blood clam Tegillarca granosa as model

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