Occurrence of pharmaceutical and personal care products (PPCPs) in wastewater and receiving waters in South Africa using LC-Orbitrap™ MS

Mhuka, Vimbai; Dube, Simiso; Nindi, Mathew Muzi

doi:10.1016/j.emcon.2020.07.002

Cited by 64 publications

(38 citation statements)

References 23 publications

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“… Mhuka et al (2020) collected water samples on different days from December 2016 to March 2018 at the Daspoort Wastewater Treatment Plant in Pretoria, South Africa. Affluent and effluent samples were collected, as well as at sampling points located along of the Apies River, both upstream and downstream of the Treatment Station.…”

Section: Resultsmentioning

confidence: 99%

A critical review on environmental presence of pharmaceutical drugs tested for the covid-19 treatment

Nippes

Macruz

Silva

et al. 2021

Process Safety and Environmental Protection

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Section: Resultsmentioning

confidence: 99%

A critical review on environmental presence of pharmaceutical drugs tested for the covid-19 treatment

Nippes

Macruz

Silva

et al. 2021

Process Safety and Environmental Protection

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“…Seventeen antibiotic compounds were targeted for detection in this study: albendazole, azithromycin, ciprofloxacin, clarithromycin, enrofloxacin, levofloxacin, norfloxacin, ofloxacin, oxytetracycline, sulfacetamide, sulfadiazine, sulfamerazine, sulfamethoxazole, sulfamoxol, sulfanilamide, sulfapyridine and trimethoprim. The extraction and quantification of antibiotics was carried out following the method proposed by Mhuka et al [ 77 ]. Briefly, the collected water samples were extracted in Dionex AutoTrace™ automated SPE (Dionex™ AutoTrace™, Thermo Scientific, Braunschweig, Germany) Unit using Waters Oasis ® HLB solid phase extraction (SPE) cartridges (Waters Corporation, Milford, MA, USA).…”

Section: Methodsmentioning

confidence: 99%

Taxonomic and Functional Distribution of Bacterial Communities in Domestic and Hospital Wastewater System: Implications for Public and Environmental Health

Selvarajan

Sibanda

Pandian³

et al. 2021

Antibiotics

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The discharge of untreated hospital and domestic wastewater into receiving water bodies is still a prevalent practice in developing countries. Unfortunately, because of an ever-increasing population of people who are perennially under medication, these wastewaters contain residues of antibiotics and other antimicrobials as well as microbial shedding, the direct and indirect effects of which include the dissemination of antibiotic resistance genes and an increase in the evolution of antibiotic-resistant bacteria that pose a threat to public and environmental health. This study assessed the taxonomic and functional profiles of bacterial communities, as well as the antibiotic concentrations in untreated domestic wastewater (DWW) and hospital wastewater (HWW), using high-throughput sequencing analysis and solid-phase extraction coupled to Ultra-high-performance liquid chromatography Mass Spectrometry (UHPLC–MS/MS) analysis, respectively. The physicochemical qualities of both wastewater systems were also determined. The mean concentration of antibiotics and the concentrations of Cl−, F− and PO43 were higher in HWW samples than in DWW samples. The phylum Firmicutes was dominant in DWW with a sequence coverage of 59.61% while Proteobacteria was dominant in HWW samples with a sequence coverage of 86.32%. At genus level, the genus Exiguobacterium (20.65%) and Roseomonas (67.41%) were predominant in DWW and HWW samples, respectively. Several pathogenic or opportunistic bacterial genera were detected in HWW (Enterococcus, Pseudomonas and Vibrio) and DWW (Clostridium, Klebsiella, Corynebacterium, Bordetella, Staphylocccus and Rhodococcus) samples. Functional prediction analysis indicated the presence of beta-lactam resistance, cationic antimicrobial peptide (CAMP) resistance and vancomycin resistance genes in HWW samples. The presence of these antibiotic resistance genes and cassettes were positively correlated with the presence of pathogens. These findings show the risk posed to public and environmental health by the discharge of untreated domestic and hospital wastewaters into environmental water bodies.

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“…The increasing concentrations of steroid hormone residues in various matrices in the environment is proof that even with the bans that are currently in place, their increased application is still predominant (Table 1). In general, global studies have shown that these hormones are frequently detected in waste and surface waters [9,29,[32][33][34][36][37][38][39][40][41][42]. The detection of steroid hormones in the environment has been reported to differ from country to country (Table 1).…”

Section: Global Concentration Levels Of Hormonesmentioning

confidence: 99%

“…In some cases, their concentrations within the same country also differ depending on the regions or provinces. For example, in South Africa, maximum concentrations for estradiol of 7133 ng/L were detected in wastewaters from Gauteng Province [42], while concentrations of up to 2000 ng/L were reported in KwaZulu Natal Province for estrone (E1), 17-βestradiol (E2), estriol (E3), 17-α-ethinylestradiol (17-α-EE2), androgens, and progestogens (PRO) [9]. Olatunji et al [45] reported concentrations ranging from 600 to 45,500 ng/L for E2 and E3 in surface water around animal farms in Western Cape.…”

Section: Global Concentration Levels Of Hormonesmentioning

confidence: 99%

Recent Advances in Solid-Phase Extraction (SPE) Based on Molecularly Imprinted Polymers (MIPs) for Analysis of Hormones

et al. 2021

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Steroid hormones are active substances that are necessary in the normal functioning of all physiological activities in the body, such as sexual characteristics, metabolism, and mood control. They are also widely used as exogenous chemicals in medical and pharmaceutical applications as treatments and at times growth promoters in animal farming. The vast application of steroid hormones has resulted in them being found in different matrices, such as food, environmental, and biological samples. The presence of hormones in such matrices means that they can easily come into contact with humans and animals as exogenous compounds, resulting in abnormal concentrations that can lead to endocrine disruption. This makes their determination in different matrices a vital part of pollutant management and control. Although advances in analytical instruments are constant, it has been determined that these instruments still require some sample preparation steps to be able to determine the occurrence of pollutants in the complex matrices in which they occur. Advances are still being made in sample preparation to ensure easier, selective, and sensitive analysis of complex matrices. Molecularly imprinted polymers (MIPs) have been termed as advanced solid-phase (SPE) materials for the selective extraction and preconcentration of hormones in complex matrices. This review explores the preparation and application of MIPs for the determination of steroid hormones in different sample types.

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Occurrence of pharmaceutical and personal care products (PPCPs) in wastewater and receiving waters in South Africa using LC-Orbitrap™ MS

Cited by 64 publications

References 23 publications

A critical review on environmental presence of pharmaceutical drugs tested for the covid-19 treatment

A critical review on environmental presence of pharmaceutical drugs tested for the covid-19 treatment

Taxonomic and Functional Distribution of Bacterial Communities in Domestic and Hospital Wastewater System: Implications for Public and Environmental Health

Recent Advances in Solid-Phase Extraction (SPE) Based on Molecularly Imprinted Polymers (MIPs) for Analysis of Hormones

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