Occurrence of perchlorate in processed foods manufactured in China

Liao, Zhenyu; Cao, Dongli; Gao, Zhibin; Zhang, Shuliang

doi:10.1016/j.foodcont.2019.106813

Cited by 34 publications

(9 citation statements)

References 32 publications

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“…In recent years, a large amount of work focuses on the natural occurrence of perchlorate in the environment. In connection with the appearance of new reports [69][70][71][72][73] on the occurrence of perchlorate in water samples, soils, vegetables, dairy products and other food products, there is a need to degrade the ClO 4 − anion to other non-toxic substances or to physically remove it from the environment. Due to high mobility of ClO 4 − in aqueous solutions, as well as its low reactivity, caused by high energy of activation and weak complexing properties, it is necessary to develop methods for decontamination of perchlorate on a large scale, because the use of conventional techniques such as coagulation, sedimentation and precipitation is expensive and inefficient [37].…”

Section: Methods Of Remediation Of Perchlorate From the Environmentmentioning

confidence: 99%

Perchlorate – properties, toxicity and human health effects: an updated review

Niziński

Błażewicz

Kończyk

et al. 2020

Reviews on Environmental Health

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Interest in perchlorate as environmental pollutant has increased since 1997, when high concentrations have been found in the waters of the Colorado River, USA. Perchlorate is very persistent in nature and it is slowly degraded. Although harmful effects of large doses of perchlorate on thyroid function have been proven, the environmental effects are still unclear. The primary objective of the present review is to collect prevailing data of perchlorate exposure and to discuss its impact on human health. The results show that more than 50% of reviewed works found significant associations of perchlorate exposure and human health. This review consists of the following sections: general information of perchlorate sources, its properties and determination methods, role and sources in human body including food and water intake, overview of the scientific literature on the research on the effect of perchlorate on human health from 2010 to 2020. Finally, conclusions and recommendations on future perchlorate studies concerning human exposure are presented.

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Section: Methods Of Remediation Of Perchlorate From the Environmentmentioning

confidence: 99%

Perchlorate – properties, toxicity and human health effects: an updated review

Niziński

Błażewicz

Kończyk

et al. 2020

Reviews on Environmental Health

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“…Terrestrial plants can accumulate perchlorate; agricultural products are regarded as a driver of trophic transfer . Numerous studies have reported perchlorate in foods with high detection frequencies and in considerable amounts in foods such as vegetables, fruits, rice, milk, and dairy products. − Hence, ingestion of food is considered as a critical source of human exposure to perchlorate.…”

Section: Introductionmentioning

confidence: 99%

“…Health-based guidance values (HBGVs) for perchlorate have been established by the United States Environmental Protection Agency [EPA, reference dose (RfD): 0.7 μg/kg bw/day, 2004], Joint FAO/WHO Expert Committee on Food Additives [JECFA, provisional maximum tolerable daily intake (PMTDI): 10 μg/kg bw/day, 2011], and European Food Safety Authority [EFSA, tolerance daily intake (TDI): 0.3 μg/kg bw/day, 2014] . Nationwide dietary exposure risk assessment for perchlorate has been conducted in the populations of China, Europe, United States, Canada, Australia, India, and South Korea. ,− These dietary risk assessments of perchlorate exhibited great variation among different populations, and some groups, such as infants, have an estimated perchlorate exposure level exceeding the value of U.S. EPA RfD (0.7 μg/kg bw/day) or EFSA TDI (0.3 μg/kg bw/day). Notably, the present exposure level to perchlorate through food intake is mainly calculated on the basis of the analyzed concentrations in food items, which may arouse uncertainty in risk assessment without considering the bioavailability (defined as the fraction of an ingested contaminant that reaches the systemic circulation from the gastrointestinal tract).…”

Section: Introductionmentioning

confidence: 99%

Bioavailability Evaluation of Perchlorate in Different Foods In Vivo: Comparison with In Vitro Assays and Implications for Human Health Risk Assessment

Liu

Zhang

Yimei

et al. 2021

J. Agric. Food Chem.

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Perchlorate in various foods continuously arouses public health concern. Bioavailability is a critical parameter to better estimate perchlorate exposure from diets. In this study, perchlorate bioavailability in five foods was determined in an in vivo mouse model and compared with in vitro bioaccessibility/bioavailability. The estimated in vivo perchlorate bioavailability for different foods ranged from 18.01 ± 4.53% to 45.60 ± 7.11%, with the order lettuce > pork > rice > milk powder > soybean. Moisture, fiber, and fat in foods were identified as critical factors affecting perchlorate bioavailability (correlation r = 0.71, 0.52, and −0.67, respectively). Linear regression analysis revealed that the in vitro perchlorate bioavailability determined using the Caco-2 cell model has the potential to estimate the in vivo perchlorate bioavailability in foods (R 2 = 0.67, slope = 1.33, and y intercept = 4.99). These findings provide insights into the effects of the food matrices on perchlorate bioavailability and could contribute to decrease the uncertainty regarding perchlorate dietary exposure risk assessment.

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“…Since the 1990s, perchlorate has been found to be widely present in drinking water and foods which has been raised as a public health concern (3). Numerous studies have reported high detection frequencies of perchlorate in foods such as vegetables, fruits, milk and other foods in amounts deserving of attention (4)(5)(6). Approximately 83% of perchlorate is exposed to humans through foods (7).…”

Section: Introductionmentioning

confidence: 99%

Targeted Lipidomics Reveal the Effect of Perchlorate on Lipid Profiles in Liver of High-Fat Diet Mice

et al. 2022

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Perchlorate, commonly available in drinking water and food, acts on the iodine uptake by the thyroid affecting lipid metabolism. High-fat diets leading to various health problems continually raise public concern. In the present study, liver lipid metabolism profiles and metabolic pathways were investigated in C57BL/6J mice chronically exposed to perchlorate using targeted metabolomics. Mice were fed a high-fat diet and treated orally with perchlorate at 0.1 mg/kg bw (body weight), 1 mg/kg bw and 10 mg/kg bw daily for 12 weeks. Perchlorate induced disorders of lipid metabolism in vivo and hepatic lipid accumulation confirmed by serum biochemical parameters and histopathological examination. There were 34 kinds of lipid in liver detected by UHPLC-MS/MS and key metabolites were identified by multivariate statistical analysis evaluated with VIP > 1, p-value < 0.05, fold change > 1.2 or < 0.8. Perchlorate low, medium and high dose groups were identified with 11, 7 and 8 significantly altered lipid metabolites compared to the control group, respectively. The results of the metabolic pathway analysis revealed that the differential metabolites classified into different experimental groups contribute to the glycerophospholipid metabolic pathway. These findings provide insights into the effects of perchlorate on lipid metabolism during long-term exposure to high-fat diets and contribute to the evaluation of perchlorate liver toxic mechanisms and health effects.

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Occurrence of perchlorate in processed foods manufactured in China

Cited by 34 publications

References 32 publications

Perchlorate – properties, toxicity and human health effects: an updated review

Perchlorate – properties, toxicity and human health effects: an updated review

Bioavailability Evaluation of Perchlorate in Different Foods In Vivo: Comparison with In Vitro Assays and Implications for Human Health Risk Assessment

Targeted Lipidomics Reveal the Effect of Perchlorate on Lipid Profiles in Liver of High-Fat Diet Mice

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