Occurrence of parasympathetic vasodilator fibers in the lower lip of the guinea-pig

Watanabe, Hiroshi; Ishii, Hisayoshi; Niioka, Takeharu; Yamamuro, Makoto; Izumi, Hiroshi

doi:10.1007/s00360-007-0222-z

Cited by 9 publications

(1 citation statement)

References 33 publications

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“…Parasympathetic and sympathetic nerve fibers projecting to blood vessels in the lower lip are from the otic ganglion, a parasympathetic ganglion [116– 119]. Stimulation of the lingual nerve in the presence of a sympathetic nervous system blocker (guanethidine; that depletes neurotransmitters in the sympathetic nerves and thus isolates the effects of stimulation to parasympathetic nerves) caused dose-dependent increases in lower lip blood flow which were prevented by blocking ganglionic transmission with hexamethonium [118]. Although evidence for parasympathetic nervous function in the skin is limited to the lower lip, cholinergic nerves are capable of migrating into shallower layers of injured skin.…”

Section: Parasympathetic Control Of the Skinmentioning

confidence: 99%

Role of Parasympathetic Nerves and Muscarinic Receptors in Allergy and Asthma

Scott

Fryer

2012

Chemical Immunology and Allergy

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Parasympathetic nerves control the symptoms and inflammation of allergic diseases primarily by signaling through peripheral muscarinic receptors. Parasympathetic signaling targets classic effector tissues such as airway smooth muscle and secretory glands and mediates acute symptoms of allergic disease such as airway narrowing and increased mucus secretion. In addition, parasympathetic signaling modulates inflammatory cells and non-neuronal resident cell types such as fibroblasts and smooth muscle contributing to chronic allergic inflammation and tissue remodeling. Importantly, muscarinic antagonists are experiencing a rebirth for the treatment of asthma and may be useful for treating other allergic diseases.

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Section: Parasympathetic Control Of the Skinmentioning

confidence: 99%

Role of Parasympathetic Nerves and Muscarinic Receptors in Allergy and Asthma

Scott

Fryer

2012

Chemical Immunology and Allergy

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Parasympathetic reflex vasodilation in the cerebral hemodynamics of rats

2014

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We investigated the role of parasympathetic reflex vasodilation in the regulation of the cerebral hemodynamics, and whether GABAA receptors modulate the response. We examined the effects of activation of the parasympathetic fibers through trigeminal afferent inputs on blood flow in the internal carotid artery (ICABF) and the cerebral blood vessels (rCBF) in parietal cortex in urethane-anesthetized rats. Electrical stimulation of the central cut end of the lingual nerve (LN) elicited intensity- and frequency-dependent increases in ICABF that were independent of changes in external carotid artery blood flow. Increases in ICABF were elicited by LN stimulation regardless of the presence or absence of sympathetic innervation. The ICABF increases evoked by LN stimulation were almost abolished by the intravenous administration of hexamethonium (10 mg kg(-1)) and were reduced significantly by atropine administration (0.1 mg kg(-1)). Although the LN stimulation alone had no significant effect on rCBF, LN stimulation in combination with a blocker of the GABAA receptor pentylenetetrazole increased the rCBF markedly. This increase in rCBF was reduced significantly by the administration of hexamethonium and atropine. These observations indicate that the increases in both ICABF and rCBF are evoked by parasympathetic activation via the trigeminal-mediated reflex. The rCBF increase evoked by LN stimulation is thought to be limited by the GABAA receptors in the central nervous system. These results suggest that the parasympathetic reflex vasodilation and its modulation mediated by GABA receptors within synaptic transmission in the brainstem are involved in the regulation of the cerebral hemodynamics during trigeminal afferent inputs.

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