Occurrence of neonicotinoid insecticides and their metabolites in tooth samples collected from south China: Associations with periodontitis

Zhang, Nan; Wang, Bata; Zhang, Zhanpeng; Chen, Xufeng; Huang, Yue; Liu, Qihui; Zhang, Hua

doi:10.1016/j.chemosphere.2020.128498

Cited by 25 publications

(8 citation statements)

References 76 publications

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“…3). A similar pattern was also found in previous reports on the levels of NEOs and their metabolites in human urine, saliva, periodontal blood, tooth, and blood samples collected from China (Song et al 2020;Xu et al 2021;Zhang et al 2021b; N. Zhang et al 2021). These results indicate that human exposure to NEOs and their metabolites might not relatively differ in these populations.…”

Section: Association Of Blood Levels With Demographic Factorssupporting

confidence: 90%

Concentrations of Neonicotinoids and their Characteristic Metabolites in Blood Samples from South China: Association with Liver Cancer

Zhang¹,

Zhang²,

Zeng³

et al. 2021

Preprint

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Neonicotinoid insecticides (NEOs) are commonly applied for pest control in China and around the world. They have potential toxicity to bees, birds, mammals, and even human being. However, limited studies have explored the associations between NEOs exposure and disease. In the present study, we detected six parent NEOs (p-NEOs), including acetamiprid, thiacloprid, dinotefuran, clothianidin, imidacloprid, and thiamethoxam, and five characteristic metabolites (m-NEOs), including 5-hydroxy-imidacloprid (5-OH-IMI), olefin-imidacloprid (Of-IMI), N-desmethyl-acetamiprid, 1-methyl-3-(tetrahydro-3-furylmethyl) guanidine and 1-methyl-3-(tetrahydro-3-furyl methyl) urea, in blood samples collected from healthy (n = 100) and liver cancer (n = 274) populations in South China. NEOs were frequently detected (61–94%) in blood samples, with median concentrations ranging from 0.19 ng/mL to 1.28 ng/mL and 0.20 ng/mL to 2.03 ng/mL for healthy and liver cancer populations, respectively. Of-IMI was the most abundant NEOs in healthy and liver cancer populations, accounting for 23.4% and 20.7%, respectively. Significant positive correlations among most m-NEOs concentrations were found, and associations between m-NEOs and their corresponding p-NEOs were positively correlated. These findings indicated that the sources of m-NEOs were both endogenous and exogeneous. Females had higher median concentrations of NEOs and their metabolites than males. Moreover, associations between the concentrations of p-NEOs and m-NEOs and liver cancer were found (odds ratio = 2.33–9.02, 95% confidence interval = 0.31–22.7, p < 0.05), indicating that human exposure to NEOs and their metabolites might increase the odds of liver cancer prevalence. This study is the first work to document 5-OH-IMI and DN in blood samples collected from South China.

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Section: Association Of Blood Levels With Demographic Factorssupporting

confidence: 90%

Concentrations of Neonicotinoids and their Characteristic Metabolites in Blood Samples from South China: Association with Liver Cancer

Zhang¹,

Zhang²,

Zeng³

et al. 2021

Preprint

Self Cite

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“…Significant positive correlations were also observed for two other pairs of p-NEOs in MS (ACE and IMI, as well as IMI and THM), with correlation coefficients ranging from 0.21 to 0.25. Similar correlations were also found between individual NEOs in human serum, 25 teeth, 26 and urine. 17 These results suggest that exposure sources to these NEOs may be common or related.…”

Section: Chemicals Andsupporting

confidence: 76%

“…16 This is concerning because recent publications have reported the detection of p-NEOs and m-NEOs in urine samples from China comprising general population, 17−19 children, 20,21 adolescents 22,23 and occupationally exposed individuals. 24 Besides urine, variable levels of NEOs were measured in other human matrices, including serum, 22,25 teeth, 26,27 hair, 28 and semen. 29 Pregnant women and fetuses are sensitive to toxic exogenous chemicals, 30 and considerable evidence exists with regard to transgenerational effects caused by NEO exposure in utero.…”

Section: ■ Introductionmentioning

confidence: 99%

“…This is concerning because recent publications have reported the detection of p-NEOs and m-NEOs in urine samples from China comprising general population, − children, , adolescents , and occupationally exposed individuals . Besides urine, variable levels of NEOs were measured in other human matrices, including serum, , teeth, , hair, and semen …”

Section: Introductionmentioning

confidence: 99%

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Neonicotinoid Insecticides and Their Metabolites Can Pass through the Human Placenta Unimpeded

Zhang

Bai

Zhang

et al. 2022

Environ. Sci. Technol.

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Studies on neonicotinoid (NEO) exposure in pregnant women and fetuses are scarce, and transplacental transfer of these insecticides is unknown. In this study, parent NEOs (p-NEOs) and their metabolites (m-NEOs) were determined in 95 paired maternal (MS) and cord serum (CS) samples collected in southern China. Imidacloprid was the predominant p-NEO in both CS and MS samples, found at median concentrations of 1.84 and 0.79 ng/mL, respectively, whereas N-desmethylacetamiprid was the most abundant m-NEO in CS (median: 0.083 ng/mL) and MS (0.13 ng/mL). The median transplacental transfer efficiencies (TTEs) of p-NEOs and m-NEOs were high, ranging from 0.81 (thiamethoxam, THM) to 1.61 (olefinimidacloprid, of-IMI), indicating efficient placental transfer of these insecticides. Moreover, transplacental transport of NEOs appears to be passive and structuredependent: cyanoamidine NEOs such as acetamiprid and thiacloprid had higher TTE values than the nitroguanidine NEOs, namely, clothianidin and THM. Multilinear regression analysis revealed that the concentrations of several NEOs in MS were associated significantly with hematological parameters related to hepatotoxicity and renal toxicity. To our knowledge, this is the first analysis of the occurrence and distribution of NEOs in paired maternal−fetal serum samples.

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“…The reported that oral damage due to exposure to N increased the levels of free radicals ( Figure 2 ) [ 60 ]. These molecules are highly reactive with the environment of the oral cavity, resulting in an intensified immune response that increases the probability of developing periodontitis ( Table 3 ; Figure 2 ) [ 60 ]. On the other hand, paraquat (B) is highly toxic in humans.…”

Section: General Effects Of Pesticides On the Oral Cavitymentioning

confidence: 99%

Impacts of Pesticides on Oral Cavity Health and Ecosystems: A Review

Salazar-Flores

Martínez

Ceja-Gálvez

et al. 2022

IJERPH

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Pesticides are chemical substances used to control, prevent, or destroy agricultural, domestic, and livestock pests. These compounds produce adverse changes in health, and they have been associated with the development of multiple chronic diseases. This study aimed to present a detailed review of the effect of pesticides on the oral cavity and the oral microbiome. In the oral cavity, pesticides alter and/or modify tissues and the microbiome, thereby triggering imbalance in the ecosystem, generating an inflammatory response, and activating hydrolytic enzymes. In particular, the imbalance in the oral microbiome creates a dysbiosis that modifies the number, composition, and/or functions of the constituent microorganisms and the local response of the host. Pesticide exposure alters epithelial cells, and oral microbiota, and disrupts the homeostasis of the oral environment. The presence of pesticides in the oral cavity predisposes the appearance of pathologies such as caries, periodontal diseases, oral cancer, and odontogenic infections. In this study, we analyzed the effect of organochlorines, organophosphates, pyrethroids, carbamates, bipyridyls, and triazineson oral cavity health and ecosystems.

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Occurrence of neonicotinoid insecticides and their metabolites in tooth samples collected from south China: Associations with periodontitis

Cited by 25 publications

References 76 publications

Concentrations of Neonicotinoids and their Characteristic Metabolites in Blood Samples from South China: Association with Liver Cancer

Concentrations of Neonicotinoids and their Characteristic Metabolites in Blood Samples from South China: Association with Liver Cancer

Neonicotinoid Insecticides and Their Metabolites Can Pass through the Human Placenta Unimpeded

Impacts of Pesticides on Oral Cavity Health and Ecosystems: A Review

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