Occurrence of Fetal Sulphoglycoprotein Antigen in the Gastric Juice of Patients with Gastric Diseases

Sulfated Muco-Substances and Gastric Diseases

“…The antipeptic activity of these sulfated glycoproteins has been demonstrated [2], Owing to pathophysiological implications they have been explored in the diseased stomach. A qualitative study of sulfated mucosubstances in the gastric juice was reported by Häkkinen [7,9,10], Three distinct antigens were obtained after immunization of rabbits against a fraction of gastric juice containing the polyanions: a normal gastric antigen in young healthy people; an intestinal antigen in older patients with atrophic gastritis; a cancer antigen in patients with gastric carcinoma, common to the fetal gastric mucosa (carcino-embryonar antigen). Sulfated muco-substances being detected in the saliva as well as in gastric secretions [21] a contamination remains possible.…”

Foetal antigens and their role in the diagnosis and clinical management of human neoplasms: a review

“…One of them, located in the cells of the superficial epithelium of the foetal stomach, disappears from this site 9 months after birth and is called foetal sulphoglycoprotein antigen (FSA). Hakkinen and Viikari (1969) (Hakkinen, Jarvi and Gironroos, 1968 (Leese, 1969). While these observations have important basic connotations in the field of differentiation, of great clinical importance are qualitative isozymic alterations which are also reflected in the body fluids.…”

“…Of great interest has been the discovery of one particular group of materials, namely " embryo-specific or foetal antigens" in association with human (Gold 24 Accepted 20 June 1972 and Freedman, 1 965a; Tee, Wang and Watkins, 1965;Yashi et al, 1968;Hakkinen and Viikari, 1969;Abelev, 1971; Klavins, Mesa-Tejada and Weiss, 1971; Trouillas, 1971) and animal tumours (Pearson and Freeman, 1968;Brawn, 1970;Coggin, Ambrose and Anderson, 1970;Duff and Rapp, 1970;Stonehill and Bendich, 1970;Alexander, 1972). The reappearance of embryo-specific materials was first postulated in human neoplasms as long ago as 1929 (Hirszfeld) and was noted by Stonehill and Bendich (1970) in diverse tumours of the mouse, rat and hamster induced by physical, viral and chemical agents, as well as those occurring spontaneously.…”

Antigens of a Human Breast Carcinoma Cell Line (BT 20). I. Synthesis of Serum Proteins, Membrane-Associated Antigens, and Oncofetal-Associated Antigens<xref ref-type="fn" rid="FN2">2</xref>

“…We have not evaluated the relationship between the 3 other fetal proteins and most of the numerous fetal proteins described to date (32,(53)(54)(55)(56)(57)(58)(59). However, we can prove that these fetoproteins are neither al-fetoprotein, BOF A, or ferritin nor components due to cultivation in medium containing FCS (60).…”