Occurrence of erectile dysfunction, testosterone deficiency syndrome and metabolic syndrome in patients with abdominal obesity. Where is a sufficient level of testosterone?

Fillo, J.; Breza, J; Levcikova, M.; Luha, Ján; Vachulova, A.; Durdík, Štefan; Labas, P

doi:10.1007/s11255-012-0132-1

Cited by 20 publications

(9 citation statements)

References 34 publications

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“…In economically developed countries, the MetS affects up to 30% of the population, and its incidence continues to increase [31]. A recent study suggests that 73% of male patients with abdominal obesity show symptoms of ED, 47% show T deficiency syndrome, and 62% of men have MetS [32]. Interestingly, 79% of men presenting ED have BMI of 25 kg/m 2 or higher; men with BMI in the range of over 30 kg/m 2 have three times greater risk of sexual dysfunction compared with normal men.…”

Section: Introductionmentioning

confidence: 99%

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A Comprehensive Review of Metabolic Syndrome Affecting Erectile Dysfunction

Kaya

Sikka

Gür

2015

The Journal of Sexual Medicine

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Introduction Metabolic syndrome (MetS) is the most important public health issue threatening the health of men and women all over the world. Its current prevalence (i.e., approximately 30%) is continuously increasing. MetS by itself is considered a risk factor for erectile dysfunction (ED). Aim To focus on the definition epidemiology, pathogenesis, and possible mechanistic links between MetS and ED in order to provide guidelines for treating such individuals. Methods The search strategies yielded total records screened from PubMed. Main Outcome Measures Regardless of the definition, MetS consists of insulin resistance, hypertension, dyslipidemia, and obesity. MetS is not an end disease but is a disorder of energy utilization and storage. Results The prevalence of ED in patients with MetS is almost twice than in those without MetS, and about 40% of patients with ED have MetS. An important mechanism linking MetS and ED is hypogonadism. Conclusions Recognizing through ED, underlying conditions such as hypogonadism, diabetes and MetS might be a useful motivation for men to improve their health-related choices. The clinical management of MetS can be done by therapeutic interventions that include lifestyle modifications, hormone replacement alone or in combination with phosphodiesterase 5 inhibitors, and other pharmacological treatments.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Comprehensive Review of Metabolic Syndrome Affecting Erectile Dysfunction

Kaya

Sikka

Gür

2015

The Journal of Sexual Medicine

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“…Studies of patients in clinical settings often include individuals with higher degrees of obesity, with most studies showing a relationship between obesity and lower levels of sexual functioning, especially ED [8]. Fillo et al [9] found that there is a positive correlation between waist circumference (WC) and ED. Also, ED is common among men with an elevated body mass index (BMI) [10].…”

Section: Introductionmentioning

confidence: 99%

Cardiometabolic Risk Factors in Patients with Erectile Dysfunction

Tanık

Sarıkaya

Zengın

et al. 2014

The Scientific World Journal

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Introduction. There is an increasing interest in the association between erectile dysfunction (ED) and cardiovascular risk factor. Epicardial adipose tissue (EAT) is associated with insulin resistance, increased cardiometabolic risk, and coronary artery disease. Our aim was to investigate relationships between epicardial fat thickness (EFT) as a cardiometabolic risk factor and erectile dysfunction. Method. We selected 30 erectile dysfunction patients without comorbidities and 30 healthy individuals. IIEF-5 score was applied to all patients, and IIEF-5 score below 22 was considered as erectile dysfunction. EFT was measured by echocardiography. Results. Body mass index (BMI) was higher in ED patients than those without ED (28.19 ± 4.45 kg/m2 versus 23.84 ± 2.36 kg/m2, P = 0.001, resp.). Waist circumstance (WC) was higher in ED patients than those without ED (106.60 ± 5.90 versus 87.86 ± 14.51, P = 0.001, resp.). EFT was higher in ED patients compared to non-ED patients (0.49 ± 0.09 cm versus 0.45 ± 0.03 cm, P = 0.016, resp.). There was positive correlation among BMI, WC, and EFT. There was negative correlation between EFT and IIEF-5 score (r : − 0.632, P = 0.001). Conclusion. EAT, BMI, and WC as cardiometabolic risk factors were higher in erectile dysfunction patients.

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“…Fillo and colleagues reported an ED prevalence of 73 % in 167 men with abdominal obesity [19]. Of this group with ED, 84 of 122 patients (68.9 %) had serum testosterone levels <14 nmol/L, and 49 (40.2 %) had levels <10 nmol/L.…”

Section: Erectile Functionmentioning

confidence: 99%

Late Onset Hypogonadism, Testosterone Replacement Therapy, and Sexual Health in Elderly Men

Griebling

2013

Curr Transl Geriatr Exp Gerontol Rep

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Testosterone levels tend to decline with advancing age in older men. Some develop symptomatic changes consistent with late onset hypogonadism. Alterations in hormone concentration can have negative impacts on multiple organ systems and physiological processes. This paper focuses on implications for sexual health in elderly men, including changes in libido, erectile function, and sexual performance. Associated concepts in cardiovascular health, cognition and mental health are reviewed. Changes in sexual function have been recognized as early indicators of underlying comorbidities, including cardiovascular diseases, metabolic syndrome, diabetes, depression, and frailty. New research developments on pathophysiology and hormone replacement therapy are highlighted.

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Occurrence of erectile dysfunction, testosterone deficiency syndrome and metabolic syndrome in patients with abdominal obesity. Where is a sufficient level of testosterone?

Abstract: Patients over 40 years of age with AO and ED should also be examined for TDS and metabolic syndrome. In this group of patients we found that 113/167 patients (67.6%) had total TST below 14 nmol/l, and sufficient level of TST seems to be above this level.

Cited by 20 publications

References 34 publications

A Comprehensive Review of Metabolic Syndrome Affecting Erectile Dysfunction

A Comprehensive Review of Metabolic Syndrome Affecting Erectile Dysfunction

Cardiometabolic Risk Factors in Patients with Erectile Dysfunction

Late Onset Hypogonadism, Testosterone Replacement Therapy, and Sexual Health in Elderly Men

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