Occurrence of drug–drug interactions in Adama Referral Hospital, Adama city, Ethiopia

Gunasekaran, Thirumurugan; Dejene, Natsanet; Satyaveni, Vanapalli V.; Dhanaraju, Magharla Dasaratha

doi:10.3109/21556660.2015.1067218

Cited by 7 publications

(8 citation statements)

References 7 publications

(8 reference statements)

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“…This was similar to the current study, although the top two groups in the cited study were for noninfectious diseases [ 8 ]. Other studies in Ethiopia also reported similar findings with anti-infectives prescribed in high proportions [ 17 – 20 ]. Looking at individual medicines, seven of the ten most frequently prescribed medicines were anti-infectives.…”

Section: Discussionsupporting

confidence: 74%

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Pattern and Appropriateness of Medicines Prescribed to Outpatients at a University Hospital in Northwestern Ethiopia

Teni

Belachew

Gebresillassie

et al. 2017

BioMed Research International

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The study assessed the pattern and appropriateness of medicines prescribed to outpatients at Gondar University Referral Hospital in northwestern Ethiopia. An institution-based cross-sectional study was employed, through interviews and prescription reviews, among 346 patients at the outpatient pharmacy, from 2nd to 20th of May 2016. Data on sociodemographic profile of patients and medicines prescribed to them were collected. A mean of 1.72 medicines per encounter was prescribed, over a third of the total being anti-infectives. Patients were able to get about 85% of these medicines. An unskilled government employee would be required to work more than one and a half day to be able to afford the average priced medicine. Among prescriptions with two or more medicines, more than a third had at least one potential drug-drug interaction (PDDI), the commonest pair containing amoxicillin and doxycycline. Being male, being older (50–59 years), and increased number of medicines were associated with higher likelihood of PDDIs. In conclusion, the number of medicines prescribed per encounter was up to accepted standard. However, their availability fell short, together with considerable cost. Regarding appropriateness, a significant proportion of potential drug-drug interactions is identified and associated with patient's sex, age, and number of medicines prescribed.

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Section: Discussionsupporting

confidence: 74%

“…These focused on a range of patient categories including pediatrics, elderly, outpatients, and inpatients. Considerable proportions of prescription of PDDIs were reported by many of these studies [ 20 – 24 ].…”

Section: Introductionmentioning

confidence: 99%

Pattern and Appropriateness of Medicines Prescribed to Outpatients at a University Hospital in Northwestern Ethiopia

Teni

Belachew

Gebresillassie

et al. 2017

BioMed Research International

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“…of patients with DDIs Prevalence patients with DDIs (%) No. of potential DDIs Major Moderate Minor Unknown& Contraindication Oromia Gunasekaran et al, 2016 [ 25 ] All All hospitalized patients All wards 300 267 89.00 62 (23.2%) 95 (35.58%) 110 (41.2%) Behailu Terefe Tesfaye et al, 2017 [ 6 ] HIV/AIDS All HIV infected patients ART Clinic 350 350 100.00 2 (0.08%) 1767 (72.69%) 662 (27.2%) Diksis et al, 2019 [ 5 ] Cardiac disorder Cardiac adult patients Medical ward 200 195 97.50 316 (32.7%) 441 (45.6%) 210 (21.7%) Chelkeba L et al, 2013 [ 26 ] Cardiac disorder Patients on CV medication in OPD Cardiac clinic 322 297 92.24 88 (29.6%) 200 (67.34%) 9 (3.03%) Amhara B.Akshaya Srikanth et al, 2014 [ 27 ] All All hospitalized patients Medical ward 100 78 78.00 53 (12.8%) 253 (61.26%) 107 (25.9%) Admassie, et al, 2013 [ 28 ] All All hospitalized patients Inpatients and Out patient 2180 711 32.61 127 (9.59%) 1020 (77.04%) 177 (13.4%) Contraindication = 11 (0.83%) …”

Section: Resultsmentioning

confidence: 99%

Prevalence of potential drug-drug interactions and associated factors among outpatients and inpatients in Ethiopian hospitals: a systematic review and meta-analysis of observational studies

Ayenew

Asmamaw

Issa

2020

BMC Pharmacol Toxicol

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Background: Drug-drug interaction is an emerging threat to public health. Currently, there is an increase in comorbid disease, polypharmacy, and hospitalization in Ethiopia. Thus, the possibility of drug-drug interaction occurrence is high in hospitals. This study aims to summarize the prevalence of potential drug-drug interactions and associated factors in Ethiopian hospitals. Methods: A literature search was performed by accessing legitimate databases in PubMed/MEDLINE, Google Scholar, and Research Gate for English-language publications. To fetch further related topics advanced search was also applied in Science Direct and HINARI databases. The search was conducted on August 3 to 25, 2019. All published articles available online until the day of data collection were considered. Outcome measures were analyzed with Open Meta Analyst and CMA version statistical software. Der Simonian and Laird's random effect model, I 2 statistics, and Logit event rate were also performed. Results: A total of 14 studies remained eligible for inclusion in systematic review and meta-analysis. From the included studies, around 8717 potential drug-drug interactions were found in 3259 peoples out of 5761 patients. The prevalence of patients with potential drug-drug interactions in Ethiopian hospitals was found to be 72.2% (95% confidence interval: 59.1, 85.3%). Based on severity, the prevalence of major, moderate, and minor potential drugdrug interaction was 25.1, 52.8, 16.9%, respectively, also 1.27% for contraindications. The factors associated with potential drug-drug interactions were related to patient characteristics such as polypharmacy, age, comorbid disease, and hospital stay. Conclusions: There is a high prevalence of potential drug-drug interactions in Ethiopian hospitals. Polypharmacy, age, comorbid disease, and hospital stay were the risk factors associated with potential drug-drug interactions.

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“…The study conducted by kumara Swamy Rc et al showed the average number of drugs per individual patient was 5.95 the present study showed that the average number of drugs per individual patient was 9.82 [8]. Thus the increasing number of drugs increases the risk of occurrence of drug-drug interactions, ADRs exponentially (Gunasekaran et al) [9].…”

Section: Discussionmentioning

confidence: 61%

Polypharmacy Induced Drug Interactions, Adverse Drug Reactions (Adr) and Medication Errors in Tertiary Care South Indian Hospital

Siddarama¹,

Naidu²,

Joshisree³

et al. 2019

Int J Pharm Pharm Sci

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Objective: To study the pattern of drug interactions (DI) in our hospital and to identify whether it is associated with polypharmacy. To determine the level of severity of potential drug-drug interactions (PDDI), to detect, monitor and prevention of ADRs in the hospitalized patients and to identify the medication errors (ME). Methods: A prospective interventional study was conducted in a 300 bedded tertiary care South Indian hospital for a period of 6 mo. Prescriptions were analysed for PDDI using Micromedex software 2.2. The causality and severity of ADRs were assessed by using Naranjo’s, WHO UMC Scales and Hart wigs severity scales. ME was identified by review of patient drug charts. Results: Total 190 prescriptions were analyzed, in which 1028 drug interactions were seen. Out of which 718 were DDI, 198 DFI, 100 DEI, and 12 DTI were observed. More number of DI was seen in cardiovascular drugs, antibiotics followed by antacids and antiulcer agents. A total of 52 ADRs were identified in 43 patients. Diuretics, cardiovascular drugs were associated with a higher incidence of ADRs followed by Anti-Diabetic agents. 58 ME was seen in 190 prescriptions, among them omission error, prescribing errors and Wrong dose error was seen. Conclusion: Clinical pharmacist plays a potential role in the health care system in assisting the physician i.e. modifying the number of drugs taken, number of doses taken, medication adherence, identification of drug interactions, preventing, monitoring and detection of ADRs and identifying the medication errors.

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Occurrence of drug–drug interactions in Adama Referral Hospital, Adama city, Ethiopia

Cited by 7 publications

References 7 publications

Pattern and Appropriateness of Medicines Prescribed to Outpatients at a University Hospital in Northwestern Ethiopia

Pattern and Appropriateness of Medicines Prescribed to Outpatients at a University Hospital in Northwestern Ethiopia

Prevalence of potential drug-drug interactions and associated factors among outpatients and inpatients in Ethiopian hospitals: a systematic review and meta-analysis of observational studies

Polypharmacy Induced Drug Interactions, Adverse Drug Reactions (Adr) and Medication Errors in Tertiary Care South Indian Hospital

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