2011
DOI: 10.1159/000323213
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Occurrence of Cleft-Palate and Alteration of <i>Tgf-</i>β<sub><i>3</i></sub> Expression and the Mechanisms Leading to Palatal Fusion in Mice following Dietary Folic-Acid Deficiency

Abstract: Folic acid (FA) is essential for numerous bodily functions. Its decrease during pregnancy has been associated with an increased risk of congenital malformations in the progeny. The relationship between FA deficiency and the appearance of cleft palate (CP) is controversial, and little information exists on a possible effect of FA on palate development. We investigated the effect of a 2–8 weeks’ induced FA deficiency in female mice on the development of CP in their progeny as well as the mechanisms leading to pa… Show more

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Cited by 24 publications
(28 citation statements)
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References 126 publications
(98 reference statements)
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“…This was also observed in a previous study by our group on the effects of a FAD on palate development (Maldonado et al, 2011). This was also observed in a previous study by our group on the effects of a FAD on palate development (Maldonado et al, 2011).…”
Section: Discussionsupporting
confidence: 90%
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“…This was also observed in a previous study by our group on the effects of a FAD on palate development (Maldonado et al, 2011). This was also observed in a previous study by our group on the effects of a FAD on palate development (Maldonado et al, 2011).…”
Section: Discussionsupporting
confidence: 90%
“…We have found many eyes from FAD animals with a thicker retina, which was clearly detached from the underlying pigment epithelium, small vitreous body with hypercellularity, and fusion of the lens epithelium to the corneal stroma, which are defects that have been described in Tgf-b2 (Sanford et al, 1997;D€ unker et al, 2003) and Tgf-bRII (Ittner et al, 2005) null mice. A reduced expression of TGF-bs has been demonstrated in other systems under a FAD (Santoso and Rohman, 2006;Maldonado et al, 2011), whereas FA supplements have proven to induce the expression of TGF-b2 (Guay et al, 2004), TGF-bRII (Yao et al, 2011), and other TGF-bs (Maldonado et al, 2011). A reduced expression of TGF-bs has been demonstrated in other systems under a FAD (Santoso and Rohman, 2006;Maldonado et al, 2011), whereas FA supplements have proven to induce the expression of TGF-b2 (Guay et al, 2004), TGF-bRII (Yao et al, 2011), and other TGF-bs (Maldonado et al, 2011).…”
Section: Discussionmentioning
confidence: 80%
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“…Altogether, human epidemiology and mouse genetic data reinforce the hypothesis that folic acid deficiency and Hcy metabolism play an important role in hearing disorders, although the mechanisms by which cochlear function is affected remain poorly understood. In this study, we used a rodent model for folic acid deficiency (26, 27) to show that reduced intake of this essential vitamin causes cochlear impairment of Hcy metabolism, oxidative stress, severe cellular damage, and apoptotic cell death, leading to accelerated hearing loss.…”
mentioning
confidence: 99%
“…16,17 However, a recent Cochrane review concluded that folic acid, alone or in combination with vitamins and minerals decreases NTD risk but did not have a clear effect on the occurrence of other birth defects. 1…”
mentioning
confidence: 99%