Folic Acid in Obstetric Practice: A Review

Talaulikar, Vikram; Arulkumaran, Sabaratnam

doi:10.1097/ogx.0b013e318223614c

Cited by 49 publications

(49 citation statements)

References 49 publications

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“…Inadequate folate consumption has been associated with cardiovascular and coronary diseases, megaloblastic anemia, stroke, depressive disorder, schizophrenia, Alzheimer's disease, and-despite inconclusiveness regarding the direction of the effect-cancer. 67,69,70 Furthermore, periconceptional folate deficiency increases the onset of various pregnancy-related diseases and outcomes, 71 with most evidence for NTDs. 72,73 In 2007, rice was for the first time successfully biofortified with folate using transgenic breeding techniques.…”

Section: Case Study On Folate-biofortified Ricementioning

confidence: 99%

The socioeconomics of genetically modified biofortified crops: a systematic review and meta‐analysis

Steur

Wesana

Blancquaert

et al. 2016

Annals of the New York Academy of Sciences

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Building upon the growing interest and research on genetically modified (GM) biofortification, its socioeconomic potential has been increasingly examined. We conducted two systematic reviews and meta-analyses to provide comprehensive evidence of consumers' willingness to pay (11 economic valuation studies, 64 estimates) and costeffectiveness/benefits (five economic evaluation studies, 30 estimates). Worldwide, consumers were willing to pay 23.9% more for GM biofortified food crops. Aside from crop and design-related differences, information provision was deemed crucial. Positive information (nutrition and GM benefits) is associated with the highest consumer willingness to pay, compared with negative, objective, and conflicting GM information, especially when negative information was mentioned last. This health intervention would reduce the aggregated micronutrient deficiency burden in Asia (15.6 million disability-adjusted life years (DALYs)) by 12.5-51.4%, at a low cost of USD 7.9-27.8 per DALY in a pessimistic and optimistic scenario, respectively. Given that GM biofortified crops could tackle hidden hunger in a cost-effective and well-accepted way, its implementation is worth pursuing. A case study on folate biofortification further elaborates on the importance of socioeconomic research and the determinants of their market potential.

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Section: Case Study On Folate-biofortified Ricementioning

confidence: 99%

The socioeconomics of genetically modified biofortified crops: a systematic review and meta‐analysis

Steur

Wesana

Blancquaert

et al. 2016

Annals of the New York Academy of Sciences

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show abstract

“…Adequate folate intake before and during the first trimester of pregnancy is important for the closure of the neural tube in the fetus, which takes place between the second and the third week of pregnancy. 1 Risk of NTD is inversely associated with folate intake 2,3 and erythrocyte folate concentration. 4 The recommended folate intake during pregnancy is twice as high as the recommended intake for the general population.…”

Section: Introductionmentioning

confidence: 99%

Determinants of folate status in pregnant women: results from a national cross-sectional survey in Belgium

et al. 2012

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BACKGROUND/OBJECTIVES: Folic acid deficiency during pregnancy can lead to neural tube defects (NTD) in the fetus. Folate status was determined in a representative sample of Belgian pregnant women and determinants of folate status were assessed. SUBJECTS/METHODS: The women were selected using a multi-stage proportionate-to-size sampling design. Blood samples were collected and a questionnaire was completed face-to-face with a study nurse. Erythrocyte (red blood cell (RBC)) folate concentration was measured by chemoluminescence. RESULTS: In total, 1311 pregnant women participated and women with a lower socio-economic status were well represented. Median RBC folate concentration was 436 ng/ml (95% confidence interval ¼ 425-452 ng/ml) among first trimester and 496 ng/ml (95% confidence interval ¼ 474-515 ng/ml) among third trimester women. Few women had a RBC folate concentration below 140 ng/ml, indicating depletion of folate stores. In the first trimester, 39% of women had a RBC concentration below 400 ng/ml, whereas 15% of the first trimester women had a RBC concentration below 300 ng/ml. Among women in the first trimester, 69.1% reported taking folic acid-containing supplements of which 41.2% started taking them before pregnancy. For third trimester women, these percentages were 76.2% and 21.9%, respectively. In both trimesters, folate status increased significantly with education level and was significantly higher among women who planned the pregnancy and who did not smoke. CONCLUSIONS: It was found that 39% of the first trimester pregnant women had a folate status that might not be optimal to prevent NTD. Some groups of women need to be targeted as they are at higher risk of inadequate folate status.

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“…This enzyme has a fundamental role in the transfer of a methyl group to homocysteine in order to make up methionine. The variant of 5, 10-methylenetetrahydrofolate reductase enzyme exists in about 5% to 15% of the general population and it can compromise tissue folate levels [22].…”

Section: Discussionmentioning

confidence: 99%

“…The active form of folate in the human body, tetrahydrofolic acid, participates as a coenzyme in several essential metabolic reactions. This coenzyme also acts as a vital component in the generation of blood cells and the synthesis and repair of genetic materials that contain nucleic acids [1][2][3][4][5]. Leafy green vegetables, spinach, fruits, and organ foods such as liver are sources rich in folate.…”

Section: Introductionmentioning

confidence: 99%

How Does Folic Acid Supplementation Affect Serum Folate Concentrations in Pregnant Turkish Women?

Özer¹,

Özer²,

Pektaş³

et al. 2016

Ann Clin Anal Med

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Folic Acid in Obstetric Practice: A Review

Cited by 49 publications

References 49 publications

The socioeconomics of genetically modified biofortified crops: a systematic review and meta‐analysis

The socioeconomics of genetically modified biofortified crops: a systematic review and meta‐analysis

Determinants of folate status in pregnant women: results from a national cross-sectional survey in Belgium

How Does Folic Acid Supplementation Affect Serum Folate Concentrations in Pregnant Turkish Women?

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