Occurrence of Bisphenol A, Estrone, 17β-Estradiol and 17α-Ethinylestradiol in Portuguese Rivers

Rocha, Sónia; Domingues, Valentina F.; Pinho, C.; Fernandes, Virgínia Cruz; Delerue–Matos, Cristina; Gameiro, Paula; Mansilha, Catarina

doi:10.1007/s00128-012-0887-1

Cited by 55 publications

(21 citation statements)

References 13 publications

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“…More than 100 t of the annual BPA production volume is released into the atmosphere (Vandenberg et al 2009 ;Cao et al 2011 ). This volume of release has made BPA environmentally ubiquitous; BPA residues are found in air, drinking water, lakes, the seas, sewage sludge, soil, house dust, foodstuffs, paper currency, among other objects and media (Ignatius et al 2010 ;Liao and Kannan 2011 ;Geens et al 2012 ;Hammer et al 2012 ;Liao et al 2012 ;Molina-García et al 2012 ;Rudel et al 2011 ;Wang et al 2012b ;Rocha et al 2013 ).…”

Section: Sources and Routes Of Bisphenol A Exposurementioning

confidence: 98%

Adverse Effects of Bisphenol A on Male Reproductive Function

Manfo

Jubendradass

Nantia

et al. 2013

Reviews of Environmental Contamination and Toxicology

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BPA is a ubiquitous environmental contaminant, resulting mainly from manufacturing,use or disposal of plastics of which it is a component, and the degradation of industrial plastic-related wastes. Growing evidence from research on laboratory animals, wildlife, and humans supports the view that BPA produces an endocrine disrupting effect and adversely affects male reproductive function. To better understand the adverse effects caused by exposure to BPA, we performed an up-to-date literature review on the topic, with particular emphasis on in utero exposure, and associated effects on spermatogenesis, steroidogenesis, and accessory organs.BPA studies on experimental animals show that effects are generally more detrimental during in utero exposure, a critical developmental stage for the embryo. BPA has been found to produce several defects in the embryo, such as feminization of male fetuses, atrophy of the testes and epididymides, increased prostate size, shortening of AGD, disruption of BTB, and alteration of adult sperm parameters (e.g.,sperm count, motility, and density). BPA also affects embryo thyroid development.During the postnatal and pubertal periods and adulthood, BPA affects the hypothalamic-pituitary-testicular axis by modulating hormone (e.g., LH and FSH,androgen and estrogen) synthesis, expression and function of respective receptors(ER, AR). These effects alter sperm parameters. BPA also induces oxidative stress in the testis and epididymis, by inhibiting antioxidant enzymes and stimulating lipid peroxidation. This suggests that employing antioxidants may be a promising strategy to relieve BPA-induced disturbances.Epidemiological studies have also provided data indicating that BPA alters male reproductive function in humans. These investigations revealed that men occupationally exposed to BPA had high blood/urinary BPA levels, and abnormal semen parameters. BPA-exposed men also showed reduced libido and erectile ejaculatory difficulties; moreover, the overall BPA effects on male reproduction appear to be more harmful if exposure occurs in utero. The regulation of BPA and BPA-related products should be reinforced, particularly where exposure during the fetal period can occur. The current TDI for BPA is proposed as 25 and 50 1-1g/kg bwt/day (European Food Safety Authority and Health Canada, respectively). Based on the evidence available, we believe that a TDI value of 5 1-1g/kg bwt/day is more appropriate (the endpoint is modulation of rat testicular function). Certain BPA derivatives are being considered as alternatives to BPA. However, certain of these related products display adverse effects that are similar to those of BPA. These effects should be carefully considered before using them as final alternatives to BPA in plastic production.

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Section: Sources and Routes Of Bisphenol A Exposurementioning

confidence: 98%

Adverse Effects of Bisphenol A on Male Reproductive Function

Manfo

Jubendradass

Nantia

et al. 2013

Reviews of Environmental Contamination and Toxicology

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“…The selected concentration of EE 2 is environmentally relevant, as in surface waters the majority of the detected EE 2 concentrations range from non-detectable to 5 ng/L (Belfroid et al, 1999;Cargouet et al, 2004;Rocha et al, 2012Rocha et al, , 2013. The Fad concentration used (50 g/L) was selected based on previous studies conducted in zebrafish (Andersen et al, 2004) and other fish species (Ankley et al, 2002;Zhang et al, 2008), where masculinization induction was reported.…”

Section: Exposure Conditionsmentioning

confidence: 99%

Zebrafish sex differentiation and gonad development after exposure to 17α-ethinylestradiol, fadrozole and their binary mixture: A stereological study

Luzio¹,

Monteiro²,

Garcia-Santos³

et al. 2015

Aquatic Toxicology

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“…Three exposure conditions were set up, in duplicate: an experimental control, EE 2 (4 ng/L) and Fad (50 g/L). The selected concentration of EE 2 is environmentally relevant, as in surface waters the majority of the detected EE 2 concentrations range from non-detectable to 5 ng/L (Belfroid et al, 1999;Cargouet et al, 2004;Rocha et al, 2012Rocha et al, , 2013. The Fad concentration used (50 g/L) was selected based on previous studies conducted on zebrafish (Andersen et al, 2005;Luzio et al, 2015bLuzio et al, , 2016a and other fish species (Ankley et al, 2002;Zhang et al, 2008), where induction of masculinization was reported.…”

Section: Experimental Designmentioning

confidence: 99%

Disruption of apoptosis pathways involved in zebrafish gonad differentiation by 17α-ethinylestradiol and fadrozole exposures

et al. 2016

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Occurrence of Bisphenol A, Estrone, 17β-Estradiol and 17α-Ethinylestradiol in Portuguese Rivers

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Cited by 55 publications

References 13 publications

Adverse Effects of Bisphenol A on Male Reproductive Function

Adverse Effects of Bisphenol A on Male Reproductive Function

Zebrafish sex differentiation and gonad development after exposure to 17α-ethinylestradiol, fadrozole and their binary mixture: A stereological study

Disruption of apoptosis pathways involved in zebrafish gonad differentiation by 17α-ethinylestradiol and fadrozole exposures

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