Occurrence of betablockers in effluents of wastewater treatment plants from the Lyon area (France) and risk assessment for the downstream rivers

Miège, Cécile; Favier, Maxime; Brosse, Corinne; Canler, J.P.; Coquery, Marina

doi:10.1016/j.talanta.2006.07.002

Cited by 52 publications

(21 citation statements)

References 16 publications

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“…During biological treatment, removal efficiencies ranged from 272.7% for sulpiride in Plant B to 97.5% for DEET in Plant C. Average overall removal efficiencies were 38.9 to 83.5% for metoprolol, 288.1 to 58.1% for sulpiride, 65.1 to 79.5% for DEET, and 10.0 to 42.8% for clofibric acid. The concentrations of metoprolol in the effluents were comparable to those reported in the other studies (Miege et al, 2006;Ternes, 1998;Vieno et al, 2006). Overall removal efficiency fell within the range of previously reported rates, from less than 10% reported by Paxéus (2004) to 83% reported by Ternes (1998).…”

Section: Resultssupporting

confidence: 87%

“…Aquatic Environmental Assessment. Several papers have assessed the aquatic environmental risk (Hernando et al, 2006;Miege et al, 2006;Santos et al, 2007;Tauxe-Wuersch et al, 2005). Risk quotients for aquatic organisms were calculated by dividing measured environmental concentration (MEC) by the predicted no-effect concentration (PNEC) of the compound.…”

Section: Resultsmentioning

confidence: 99%

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Occurrence of Selected Pharmaceuticals and Caffeine in Sewage Treatment Plants and Receiving Rivers in Beijing, China

Zhou

Huang

et al. 2010

Water Environment Research

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The occurrence of nine different types of pharmaceuticals and caffeine were analyzed in various units of three wastewater treatment plants (WWTPs) and their receiving rivers in Beijing, China. Analyte concentrations were determined using ultra performance liquid chromatograph‐tandem quadruple mass spectrometers (UPLC‐MS/MS) and multiple‐reaction monitoring. The studied pharmaceuticals and caffeine were found in all the WWTPs and receiving rivers. Their concentrations in the WWTP influents varied from 38 ng/L of sulpiride to 89.5 µg/L of caffeine, and those in the effluents ranged from 27 ng/L of sulpiride to 2.7 µg/L of erythromycin. Typically, the biological treatment appeared more effective in the removal of pharmaceuticals and caffeine than primary treatment in a WWTP. For an individual compound, the overall removal efficiency varied from one WWTP to the next. Mean values ranged from no removal of carbamazepine to 99.8% removal of caffeine. Most of the compounds in the receiving rivers were present at similar or higher concentrations compared to those in the WWTP effluents. The data set for this study does not include variations in concentrations along receiving waters because there were other point and nonpoint sources discharging to these rivers. The preliminary aquatic environmental risk assessment showed that carbamazepine, erythromycin, and trimethoprim is a potential chronic environmental risk in water bodies in Beijing, China, and is worth further investigation.

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Section: Resultssupporting

confidence: 87%

Section: Resultsmentioning

confidence: 99%

Occurrence of Selected Pharmaceuticals and Caffeine in Sewage Treatment Plants and Receiving Rivers in Beijing, China

Zhou

Huang

et al. 2010

Water Environment Research

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“…They are also used in veterinary medicine and illegally as doping in many sports (Amendola et al, 2000;Huggett et al, 2002;Barbieri et al, 2012). For example, in 1999 the usage of PRO in France already reached over 35 tons (Miège et al, 2006). A rapidly growing pharmaceutical industry, the progressive evolution of farming and ineffective methods of elimination of these medicines from wastewater are causing the appearance of these compounds in the aquatic and terrestrial environmental compartment in the range of ng L −1 even up to μg L −1 - Table 1.…”

Section: Introductionmentioning

confidence: 99%

Beta-blockers in the environment: Part I. Mobility and hydrolysis study

Maszkowska¹,

Stolte²,

Kumirska³

et al. 2014

Science of The Total Environment

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“…21,22 Apart from their more general use in Brazil, to the best of our knowledge, β-blockers have not been investigated until now. Although current in developed countries, 23,24 the employment of risk assessment tools to evaluate the widespread disposal of drugs in hospital effluents in developing countries is also a new breakthrough.…”

Section: Introductionmentioning

confidence: 99%

Multivariate optimization of analytical methodology and a first attempt to an environmental risk assessment of β-blockers in hospital wastewater

Wilde¹,

Kümmerer²,

Martins³

2012

J. Braz. Chem. Soc.

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O presente estudo avalia, preliminarmente, o risco da exposição ambiental a β-bloqueadores em efluente de um hospital universitário (Hospital Universitário de Santa Maria (HUSM), Rio Grande do Sul). Propranolol mostrou o maior quociente de risco (0,56). A ocorrência de β-bloqueadores foi avaliada com auxílio de metodologia de SPE-HPLC-FLD (extração por fase sólida-cromatografia líquida de alta eficiência com detecção por fluorescência) otimizando-se multivariadamente as variáveis pH da amostra, pH da água e a razão entre metanol:acetonitrila:ácido fórmico. As concentrações médias de atenolol, metoprolol e propranolol medidas durante o período de uma semana foram de 2,45 ± 1,14, 4,67 ± 1,63 e 0,70 ± 0,88 μg L -1 no efluente do pronto atendimento, 0,95 ± 0,68, 0,70 ± 0,33 e 0,315 ± 0,62 μg L -1 no efluente geral do hospital e 1,26 ± 0,47, 1,27 ± 0,35 e 0,56 ± 0,47 μg L -1 no córrego receptor, respectivamente. Propranolol mostrou razão MEC/PNEC > 1 (MEC: concentração ambiental mensurada e PNEC: concentração predita que não causa efeito), exigindo maior atenção em termos de toxicidade. A ocorrência de β-bloqueadores e o risco ambiental associado demonstram a necessidade de um sistema mais eficiente de tratamento do efluente hospitalar.This preliminary study evaluated an assessment of the risks arising from environmental exposure to β-blockers from wastewater of an university hospital (University Hospital of Santa Maria (HUSM), Rio Grande do Sul State, Brazil). Propranolol showed the highest risk quotient (0.56). The occurrence of β-blockers was evaluated using an analytical procedure SPE-HPLC-FLD (solid phase extraction-high performance liquid chromatography with fluorescence detection), optimizing the variables sample pH, water pH, and methanol:acetonitrile:formic acid ratio of the elution stage. The average concentrations of atenolol, metoprolol and propranolol for a sampling period of one week were 2.45 ± 1.14, 4.67 ± 1.63 and 0.70 ± 0.88 μg L -1 in the 'Emergence' sewage; 0.95 ± 0.68, 0.70 ± 0.33 and 0.315 ± 0.62 μg L -1 in the 'HUSM general' sewage and 1.26 ± 0.47, 1.27 ± 0.35 and 0.56 ± 0.47 μg L -1 in the 'Receiving waters', the receptor stream of the effluents, respectively. Propranolol showed an MEC/PNEC ratio > 1, and thus requires more attention in terms of toxicity. The occurrence of β-blockers and the associated environmental risks demonstrate the need of a more efficient treatment system for the hospital wastewater.

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Occurrence of betablockers in effluents of wastewater treatment plants from the Lyon area (France) and risk assessment for the downstream rivers

Cited by 52 publications

References 16 publications

Occurrence of Selected Pharmaceuticals and Caffeine in Sewage Treatment Plants and Receiving Rivers in Beijing, China

Occurrence of Selected Pharmaceuticals and Caffeine in Sewage Treatment Plants and Receiving Rivers in Beijing, China

Beta-blockers in the environment: Part I. Mobility and hydrolysis study

Multivariate optimization of analytical methodology and a first attempt to an environmental risk assessment of β-blockers in hospital wastewater

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Occurrence of betablockers in effluents of wastewater treatment plants from the Lyon area (France) and risk assessment for the downstream rivers

Cited by 52 publications

References 16 publications

Occurrence of Selected Pharmaceuticals and Caffeine in Sewage Treatment Plants and Receiving Rivers in Beijing, China

Occurrence of Selected Pharmaceuticals and Caffeine in Sewage Treatment Plants and Receiving Rivers in Beijing, China

Beta-blockers in the environment: Part I. Mobility and hydrolysis study

Multivariate optimization of analytical methodology and a first attempt to an environmental risk assessment of &#946;-blockers in hospital wastewater

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Multivariate optimization of analytical methodology and a first attempt to an environmental risk assessment of β-blockers in hospital wastewater