Beta-blockers in the environment: Part I. Mobility and hydrolysis study

Maszkowska, Joanna; Stolte, Stefan; Kumirska, Jolanta; Łukaszewicz, Paulina; Mioduszewska, Katarzyna; Puckowski, Alan; Caban, Magda; Wagil, Marta; Stepnowski, Piotr; Białk‐Bielińska, Anna

doi:10.1016/j.scitotenv.2014.06.023

Cited by 89 publications

(40 citation statements)

References 45 publications

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“…The MT sorption on this kaolinite is much higher than a K L of 0.07 L/mg and an S m of 12 mg/kg, or 0.045 mmol/kg for MT sorption on another kaolinite, whose CEC value was 30 mmol c /kg [28]. On the contrary, the K L and S m values were 0.003 L/mg and 13.9 mg/g, or 52 mmol c /kg, for MT adsorption on a different kaolin whose CEC value was not provided [1].…”

Section: Mt Sorption Isothermmentioning

confidence: 78%

“…If Freundlich isotherm was used, the K f and n values were 7.2 mmol 1Àn L n /kg and 0.77 for MT uptake on kaolinite, and 12.5 mmol 1Àn L n /kg and 0.3 for MT uptake on talc, in comparison with 1.16 mg 1Àn L n /kg and 0.94 for MT adsorption on another kaolinite [28]. The K f values were 1.18 and 11.9 and n values were 1.13 and 0.77 for MT sorption on Burgen and Dausenau sediments, respectively [37].…”

Section: Mt Sorption Isothermmentioning

confidence: 99%

“…In a hydrolytic stability test, MT was found stable under pH 4, 7, and 9, with an estimated haft-life of more than a year in aquatic environments at 25°C [28]. Laboratory measurements of direct photolysis of MT resulted in a t 1/2 of 630 and 990 h with initial MT concentrations of 1 and 10 mg/L [24].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Contrasting mechanisms of metoprolol uptake on kaolinite and talc

Fitzgerald

Albert

et al. 2015

Chemical Engineering Journal

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Section: Mt Sorption Isothermmentioning

confidence: 78%

Section: Mt Sorption Isothermmentioning

confidence: 99%

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Contrasting mechanisms of metoprolol uptake on kaolinite and talc

Fitzgerald

Albert

et al. 2015

Chemical Engineering Journal

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“…The removal of b-blockers by some of the WWTPs was relatively poor (Santos et al 2013). As a result, the presence of b-blockers in the environment with concentrations in lg/L has been reported (Maszkowska et al 2014a). Although bblockers are safe for humans, some of the b-blockers are harmful to some aquatic organisms (Maszkowska et al 2014b).…”

Section: Introductionmentioning

confidence: 99%

Degradation of β-blockers in water by sulfate radical-based oxidation: kinetics, mechanism and ecotoxicity assessment

Tay

Ismail

2016

Int. J. Environ. Sci. Technol.

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This study investigated the kinetics and degradation pathway of acebutolol, metoprolol and sotalol in a sulfate radical-based advanced oxidation process. The selected pharmaceuticals were b-blockers which have been used to treat cardiovascular diseases. Due to its frequent use, the presence of these pharmaceuticals in the environment has been regularly reported. In this study, sulfate radicals were generated using peroxymonosulfate with cobalt (II) as activator. At pH 7 and 25°C, the secondorder rate constant for the reaction between SO 4 Á-with metoprolol, acebutolol and sotalol was (1.0 ± 0.1) 9 10 10 , (2.0 ± 0.1) 9 10 10 and (3.0 ± 0.2) 9 10 10 M -1 s -1 , respectively. Sixteen transformation by-products were identified from the selected b-blockers. These transformation by-products were mainly formed through the hydroxylation, aromatic ring-opening reaction and aliphatic chain oxidation. The decomposition of b-blockers by sulfate radicals was found to start from the formation of hydroxylated b-blockers followed by an aromatic ring-opening reaction. In general, this study showed that b-blockers reacted favorably with sulfate radicals, and various transformation by-products could be produced. The result from the ecotoxicity assessment showed that almost all of the transformation by-products were less toxic than its parent compound. Therefore, a sulfate radical-based advanced oxidation process could be an effective method for the treatment of b-blockers in water.

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“…Among those pollutants found in water, there is also a mention of β-blockers including atenolol and esmolol. Detection of these drugs in water samples have also been reported by some workers 3,4 . The drugs enter water when people excrete them and simply flush out the outdated and unused drugs.…”

Section: Fig 1: Chemical Structures Of Drugs: a Atenolol B Esmololmentioning

confidence: 56%

Untitled

2017

IJPSR

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Atenolol and esmolol drugs belonging to a β-blocker group are frequently used for the treatment of cardiovascular diseases. These drugs are also charged as water pollutants. A new simple and rapid spectrophotometric method has been developed for their determination in pharmaceutical formulations and in spiked water samples. The proposed method is based on the derivatization of the amino function present in these drugs to the corresponding yellow copper (I) drug dithiocarbamate derivative through reaction with carbon disulphide, pyridine and copper (I) perchlorate in aqueous acetonitrile. The analysis is accomplished for their determination in pharmaceutical formulations by measuring absorbance at 425 nm for atenolol and 420 nm for esmolol. For the determination of these drugs in spiked water samples, the coloured complex is extracted into chloroform and the absorbance of the chloroform extracts is measured at 415 nm and 410 nm for atenolol and esmolol respectively. Linear correlation is obtained in the range 1.00 -22.00 and 1.50 -25.00 µg mL -1 with detection limits of 0.10 and 0.15µg mL -1 for atenolol and esmolol respectively. The proposed methods show good recoveries of atenolol and esmolol from pharmaceutical formulations and spiked water samples and are in the ranges from 99.00 -100.40% and 98.20 -100.80% respectively. The 1:1 stoichiometry of the colour reaction between drug as dithiocarbamate derivative and copper (I) perchlorate has been established by photometric titrations. The latter also provides an alternative method for the determination of above drugs in pharmaceutical formulations.

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Beta-blockers in the environment: Part I. Mobility and hydrolysis study

Cited by 89 publications

References 45 publications

Contrasting mechanisms of metoprolol uptake on kaolinite and talc

Contrasting mechanisms of metoprolol uptake on kaolinite and talc

Degradation of β-blockers in water by sulfate radical-based oxidation: kinetics, mechanism and ecotoxicity assessment

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