Occurrence of and Risk Factors for Ocular Hypertension and Secondary Glaucoma in Juvenile Idiopathic Arthritis-associated Uveitis

Stroh, Inna G.; Moradi, Ahmadreza; Burkholder, Bryn M.; Hornbeak, Dana M.; Leung, Theresa G.; Thorne, Jennifer E.

doi:10.3109/09273948.2016.1142573

Cited by 23 publications

(7 citation statements)

References 21 publications

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“…Stroh et al found that children with JIA and raised IOP are threefold more likely to be registered legally blind 13. The mean BCVA was stable at last follow-up at 0.28 logMAR in our population and the overall incidence of blind eyes was 5.3%, in keeping with the rate in recent literature3 but a drastic improvement from an older study,5 where one-third of the uveitic eyes with glaucoma had no perception of light.…”

Section: Discussionsupporting

confidence: 87%

Incidence, management and outcome of raised intraocular pressure in childhood-onset uveitis at a tertiary referral centre

et al. 2018

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Section: Discussionsupporting

confidence: 87%

Incidence, management and outcome of raised intraocular pressure in childhood-onset uveitis at a tertiary referral centre

et al. 2018

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“…A study by Skarin et al [28] found that frequencies of cataract and uveitic glaucoma in patients with JIA-U increased with uveitis duration, and cataract was present in 51%, whereas uveitic glaucoma was present in 22% at 24 years, which agrees with our findings (cataract was present in 57.14%, and ocular hypertension and glaucoma were present in 19.05% of our patients with JIA-U). However, a study by Stroh et al [29] reported that the frequency of ocular hypertension or secondary glaucoma in patients with JIA-associated uveitis can be as high as 40%, which is two times as high as our value.…”

Section: Resultscontrasting

confidence: 76%

Features of the course and treatment of JIA-associated uveitis

Panchenko¹,

Shevchenko²,

Demianenko³

et al. 2019

Oftalmol Zh

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To investigate the features of the clinical course of and the state of eye care for patients with juvenile idiopathic arthritis (JIA)-associated uveitis (JIA-U). Materials and Methods: We analyzed the results of monitoring 121 patients aged 7 to 18 years with JIA. Twenty one (17.35%) of these had uveitis. Results: In 17 (80.95%) of the examined JIA-U patients, JIA onset age was younger than 6 years, and mean JIA onset age was significantly younger than in JIA patients without uveitis (2.89±0.26 years vs 6.43±0.4 years, р<0.05). Most (85.7%) JIA-U patients were asymptomatic. Chronic keratic precipitates and posterior synechiae were found in 38.09% and 42.85%, respectively, of cases. Uveal cataract was the most common complication (57.14%), followed by corneal degeneration (33.33%), macular edema (28.57%), ocular hypertension/ secondary glaucoma (19.05%), optic nerve edema (14.28%), hypotony (14.28%), vitreous fibrosis (9.52%), and retinal detachment (4.76%). The frequency of administration of biologics was 57.14%. The mean time from disease onset to administration of biologics in our JIA-U patients (2.67±0.79 years) was 2.5 times less than the value for JIA-U patients from all over Ukraine (6.9 years), indicating that biologics were timely administered. Conclusion: Patients with the condition are commonly asymptomatic and have frequent ocular complications, with uveal cataract being the most common, followed by corneal degeneration and macular edema.

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“…In a recent retrospective analysis including 108 patients with JIA-associated uveitis, the authors described the incidence of ocular hypertension and secondary glaucoma in 40% of eyes at presentation and a three-fold higher incidence of legal blindness during a 5-year median follow-up ( 16 ). Moreover, the authors found a correlation between the use of systemic corticosteroids at presentation and incidence of hypertension/secondary glaucoma, concluding that an early and aggressive immunosuppressive therapy may reduce the risk of developing such complications.…”

Section: Discussionmentioning

confidence: 99%

Long Term Experience in Patients With JIA-Associated Uveitis in a Large Referral Center

Marelli

Romano²,

Pontikaki³

et al. 2021

Front. Pediatr.

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Objectives: To describe demographic, clinical and therapeutic findings of a large cohort of patients with JIA-associated uveitis in a nationwide referral pediatric rheumatology and uveitis center in Northern Italy.Methods: Retrospective study of 125 patients with JIA-associated uveitis followed from 2009 to 2019. Demographic and rheumatologic features including JIA ILAR classification, age at onset, and laboratory data were recorded. Ocular findings collected were: anatomic location of uveitis, laterality, type, recurrence rate, visual acuity, ocular complications, and local therapy. Systemic therapy with conventional and biologic immunosuppressants, occurrence of adverse events, and duration of treatments were recorded.Results: One hundred and twenty-five patients with JIA-associated uveitis were followed for a meantime of 9.2 (±1.7) years. Oligoarticular JIA was present in 92.8% of patients and anterior uveitis in 96%. The most common ocular complications recorded in our sample were posterior synechiae (37.6%), cataract (20.8%), band keratopathy (19.2%), glaucoma (7.2%), and macular edema (5.6%). Conventional immunosuppressants were used in 75.2% of patients with a mean duration of 9.1 years (±5.4), while biologics were administered in 47.2% of them for a period of 5.4 years. Adverse events (AE) were seen in 23% of patients being treated with Methotrexate, in 10.4% of patients treated with Adalimumab, in 38.5% of patients in therapy with Infliximab, and in 14.3% of patients being treated with Tocilizumab. No AE were reported in patients treated with Golimumab, Certolizumab, Abatacept and Rituximab.Conclusions: An aggressive treatment approach for patients with JIA-associated uveitis ensured a low number of ocular complications with a good safety profile.

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Occurrence of and Risk Factors for Ocular Hypertension and Secondary Glaucoma in Juvenile Idiopathic Arthritis-associated Uveitis

Abstract: OHT and SG were common in patients with JIA-associated uveitis. Use of immunosuppressive drugs may decrease the risk of developing OHT.

Cited by 23 publications

References 21 publications

Incidence, management and outcome of raised intraocular pressure in childhood-onset uveitis at a tertiary referral centre

Incidence, management and outcome of raised intraocular pressure in childhood-onset uveitis at a tertiary referral centre

Features of the course and treatment of JIA-associated uveitis

Long Term Experience in Patients With JIA-Associated Uveitis in a Large Referral Center

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