Occurrence of 44 elements in human cord blood and their association with growth indicators in newborns

Cabrera-Rodríguez, Raúl; Luzardo, Octavio P.; González-Antuña, Ana; Boada, Luís D.; Almeida-González, Maira; Camacho, María; Zumbado, Manuel; Acosta-Dacal, Andrea; Rial-Berriel, Cristian; Henríquez-Hernández, Luis Alberto

doi:10.1016/j.envint.2018.03.048

Cited by 71 publications

(28 citation statements)

References 53 publications

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“…For our primary analysis, we restricted to metals a) that were above the LOD for ≥60% of participants and b) for which urine is considered an accepted matrix for assessing exposure (ATSDR 1992;Chou et al 2007;Faroon et al 2004Faroon et al , 2012Fay and Ingerman 2005;Risher and DeWoskin 1999). Our primary analysis was further restricted to metals for which there was evidence that they may impact fetal growth (Cabrera-Rodríguez et al 2018;Deyssenroth et al 2018;Hoffman 2000;Jalali and Koski 2018;Khoshhali et al 2020;Kim et al 2017;Mikelson et al 2019;Milton et al 2017;Pedersen et al 2016;Rabito et al 2014;Rodosthenous et al 2017;Sun et al 2018;Vaktskjold et al 2007;Vejrup et al 2014;Vigeh et al 2018). Six metals (As, Cd, Co, Hg, Ni, Tl) met all three criteria.…”

Section: Urine Metalsmentioning

confidence: 99%

“…For example, cobalt (Co) is a component of vitamin B12 that has been associated with higher BW (Mikelson et al 2019). In addition, some metals, such as nickel (Ni) exhibit both toxic and nutritional properties (Nielsen 2012), and both adverse and protective effects have been reported in relation to fetal growth (Cabrera-Rodríguez et al 2018;Deyssenroth et al 2018;Jalali and Koski 2018;Pedersen et al 2016;Sun et al 2018;Vaktskjold et al 2007).…”

Section: Introductionmentioning

confidence: 99%

“…Yet, in combination, certain metals may exert toxic effects even at relatively low levels of exposure owing to synergistic effects (Claus Henn et al 2014), whereas other metals may act antagonistically by inhibiting each other's absorption or tissue uptake (Davidson et al 2015). Although several recent studies have begun examining simple mixtures (e.g., three elements) in relation to fetal growth (Cabrera-Rodríguez et al 2018;Cassidy-Bushrow et al 2019;Signes-Pastor et al 2019), few studies have considered complex mixtures (Deyssenroth et al 2018;Govarts et al 2016), which are more representative of human exposures. This has been particularly understudied in minority populations in the United States.…”

Section: Introductionmentioning

confidence: 99%

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Prenatal Metal Mixtures and Birth Weight for Gestational Age in a Predominately Lower-Income Hispanic Pregnancy Cohort in Los Angeles

Howe

Henn

Eckel

et al. 2020

Environ Health Perspect

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BACKGROUND: Reduced fetal growth increases the risk for adverse health outcomes. Growing evidence suggests that metal exposures contribute to reduced fetal growth, but little is known about the effects of complex metal mixtures. OBJECTIVES: We investigated the impact of a complex mixture of metals on birth weight for gestational age (BW for GA) in the Maternal and Developmental Risks from Environmental and Social Stressors study, a predominately lower-income Hispanic pregnancy cohort in Los Angeles, California. METHODS: Cadmium (Cd), cobalt (Co), mercury (Hg), nickel (Ni), molybdenum (Mo), lead (Pb), antimony (Sb), tin (Sn), and thallium (Tl) were measured by inductively coupled plasma mass spectrometry (ICP-MS) in maternal urine samples collected in early pregnancy (median GA: 13.1 wk). Speciated urinary arsenic (As) (inorganic+monomethyl+dimethyl As) was measured by high-performance liquid chromatography coupled to ICP-MS. Primary analyses focused on a mixture of seven metals that have previously been associated individually with fetal growth (i.e., As, Cd, Co, Hg, Ni, Pb, Tl) (n = 262). In exploratory analyses, we additionally examined three metals that have been less studied in relation to fetal growth (i.e., Mo, Sb, Sn). Covariate-adjusted Bayesian kernel machine regression was used to investigate metal mixture associations with BW for GA z-scores. RESULTS: In primary analyses, Hg and Ni ranked highest as predictors of BW for GA. An inverse linear association was estimated for Hg, whereas a positive association was estimated for Ni at low-to-moderate concentrations. A potential interaction between Hg and Ni was also identified. In our exploratory analysis, Sb ranked highest as a predictor of BW for GA, followed by Hg and Ni. CONCLUSIONS: Our findings suggest that in this understudied population, Hg may reduce fetal growth, whereas Ni may promote fetal growth. We also identified Sb as a potential metal of concern for this population, which merits additional investigation.

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Section: Urine Metalsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prenatal Metal Mixtures and Birth Weight for Gestational Age in a Predominately Lower-Income Hispanic Pregnancy Cohort in Los Angeles

Howe

Henn

Eckel

et al. 2020

Environ Health Perspect

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“…The present series represents the 86.6% of the total births during the recruited period (March 1, 2015, to April 30, 2016). Birth parameters were recorded at the delivery room, as previously reported [1]. Data referred to mothers were recorded and included anonymously in the database.…”

Section: Experimental Design Materials and Methodsmentioning

confidence: 99%

Database of persistent organic pollutants in umbilical cord blood: Concentration of organochlorine pesticides, PCBs, BDEs and polycyclic aromatic hydrocarbons

et al. 2020

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Persistent organic pollutants (POPs) have been banned over the last decades for being damaged to the environment and to the health of humans and animals. However, due to their lipophilic nature and resistance to degradation, they are frequently detected in biological samples. Its presence has been associated with the increased risk of suffering from different diseases in human series, being newborns and children especially sensitive. The present data reports umbilical cord blood levels of twenty organochlorine pesticides (aldrin, dieldrin, endrin, o,p'-DDD, p,p'-DDD, o,p'-DDE, p,p'-DDE, o,p'-DDT, p,p'-DDT, endosulfan alfa, endosulfan beta, endosulfan sulphate, heptachlor, HCB, αHCH, βHCH, δHCH, lindane, methoxychlor and mirex), eighteen polychlorinated biphenyls (congeners 28, 52, 77, 81, 101, 105, 114, 118, 123, 126, 138, 153, 156, 157, 167, 169, 180 and 189), eight bromodiphenyl ethers (congeners 28, 47, 85, 99, 100, 153, 154 and 183), and sixteen polycyclic aromatic hydrocarbons (acenaphthalene, acenaphthene, anthracene, benzo(a)anthracene, benzo(a)pyrene, benzo(b)fluoranthene, benzo(g,h,i)perylene, benzo(k)fluoranthene, chrysene, dibenzo(a,h)anthracene, fluoranthene, fluorine, indene(1,2,3-cd)pyrene, naphthalene, phenanthrene and pyrene). A total of 447 samples, representing 86.6% of the total births during the recruited period (March 1, 2015, to April 30, 2016), were available for POP analyses. POPs were determined in a Gas Chromatography (GC) system equipped with an automated sampler (Models 7890B and 7693; Agilent Technologies, Palo Alto, CA, USA) for gas chromatographic separations. The detection of the analytes was performed using a Triple Quad 7010 mass spectrometer (Agilent Technologies). All of the measurements were performed as triplicate measurements, and the means were used for the calculations. Data are reported in ng/mL. The present data also includes birth parameters, including weight, length, cranial perimeter, Apgar score and congenital malformations, and data referred to mothers (harmful habits, chronic diseases, and anthropometric/demographic characteristics).

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“…Although some of these elements are relatively abundant in the Earth's crust (i.e., cerium is as abundant as copper), REEs have been included among the new and emerging occupational and environmental health risks by several international organizations [17]. Different studies have shown that some of these elements have an adverse effect on people's health [18][19][20], although the mechanisms of action are not clear [17,21].…”

Section: Introductionmentioning

confidence: 99%

Association between Heavy Metals and Rare Earth Elements with Acute Ischemic Stroke: A Case-Control Study Conducted in the Canary Islands (Spain)

Medina-Estévez

Zumbado

Luzardo

et al. 2020

Toxics

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The role of inorganic elements as risk factors for stroke has been suggested. We designed a case-control study to explore the role of 45 inorganic elements as factors associated with stroke in 92 patients and 83 controls. Nineteen elements were detected in >80% of patients and 21 were detected in >80% of controls. Blood level of lead was significantly higher among patients (11.2 vs. 9.03 ng/mL) while gold and cerium were significantly higher among controls (0.013 vs. 0.007 ng/mL; and 18.0 vs. 15.0 ng/mL). Lead was associated with stroke in univariate and multivariate analysis (OR = 1.65 (95% CI, 1.09–2.50) and OR = 1.91 (95% CI, 1.20–3.04), respectively). Gold and cerium showed an inverse association with stroke in multivariate analysis (OR = 0.81 (95% CI, 0.69–0.95) and OR = 0.50 (95% CI, 0.31–0.78)). Future studies are needed to elucidate the potential sources of exposure and disclose the mechanisms of action.

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Occurrence of 44 elements in human cord blood and their association with growth indicators in newborns

Cited by 71 publications

References 53 publications

Prenatal Metal Mixtures and Birth Weight for Gestational Age in a Predominately Lower-Income Hispanic Pregnancy Cohort in Los Angeles

Prenatal Metal Mixtures and Birth Weight for Gestational Age in a Predominately Lower-Income Hispanic Pregnancy Cohort in Los Angeles

Database of persistent organic pollutants in umbilical cord blood: Concentration of organochlorine pesticides, PCBs, BDEs and polycyclic aromatic hydrocarbons

Association between Heavy Metals and Rare Earth Elements with Acute Ischemic Stroke: A Case-Control Study Conducted in the Canary Islands (Spain)

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