Occurrence, harmful effects and analytical determination of Ochratoxin A in coffee

Nuhu, Abdulmumin A.

doi:10.7324/japs.2015.50121

Cited by 2 publications

(1 citation statement)

References 99 publications

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“…The United States Food and Drug Administration (FDA) estimates that counterfeits make up more than 10% of the global medicines market [29]. The counterfeits include drugs without sufficient active ingredients, without any active ingredients, or fake packaging [30].…”

Section: Detection Of Counterfeit Pharmaceutical Productsmentioning

confidence: 99%

Chemometrics-Assisted UV-Vis Spectrophotometry for Quality Control of Pharmaceuticals: A Review

et al. 2023

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Spectroscopic method in the UV-Vis region is considered the most molecular spectrometric method for content determination of a single component. However, a lot of pharmaceutical dosage forms comprise two or more components which lead to peak overlapping. Moreover, in the chemical stability test, active pharmaceutical ingredient (API) was also found along with the degradation products, impurities, and adulterant compounds. UV-Vis spectroscopy is one of the methods of choice for the determination or quantification of a single component in pharmaceutical preparations. The pharmaceutical products typically contain two or more APIs having chromophoric agents capable of absorbing UV-Vis beams and the absorbance values are summative from the absorption of each UV-Vis active compound according to the additive nature of Lambert-Beer law. The main problem for the simultaneous determination of API along with impurities and the degradation products in pharmaceutical preparations is the presence of overlapping peaks of UV-Vis spectra. The chemometrics-assisted spectroscopy is one of the analytical efforts to solve these problems. This review highlighted the application of chemometrics in combination with UV-Vis spectroscopy for the assay of API, impurities, adulteration issues and degradation products present in pharmaceutical dosage forms.

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Section: Detection Of Counterfeit Pharmaceutical Productsmentioning

confidence: 99%

Chemometrics-Assisted UV-Vis Spectrophotometry for Quality Control of Pharmaceuticals: A Review

et al. 2023

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Survey of Ochratoxin A in coffee, dried grapes and grape pekmez samples in Burdur, Turkey

Yurdakul

Kocasari

Yalçin

et al. 2019

Uludağ Üniversitesi Veteriner Fakültesi Dergisi

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The aim of this study was to investigate the occurrence and levels of ochratoxin A (OTA) in coffee (roasted and instant), dried grapes and grape pekmez samples consumed in Burdur city markets. During 2015, a total of 86 samples including 43 coffee (30 instant coffee and 13 roasted coffee), 17 dried grapes and 26 grape pekmez were randomly collected from different markets of Burdur. The occurrence and contamination levels of OTA in the samples were investigated by the competitive enzyme-linked immunoabsorbent assay (ELISA) method. OTA was detected in 24 (55 %) coffee samples (13 roasted coffee and 11 instant coffee samples) and in 1 (3 %) grape pekmez samples. The range OTA levels were 8.34 and 22.54 µg/kg in coffee samples and 20.48 µg/kg in one grape pekmez sample, respectively. The highest recorded OTA concentration was 22.54 µg/kg in instant coffee. Furthermore, 13 roasted coffee, 11 instant coffee and 1 grape pekmez samples were contaminated at levels above the Turkish legal limits of 5 µg/kg,10 µg/kg and 2 µg/kg, respectively. In contrast, OTA was not detected in all dried grape samples. It is concluded that the occurrence of OTA, coffee samples, in particular may be considered as a possible hazard for public health.

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Occurrence, harmful effects and analytical determination of Ochratoxin A in coffee

Cited by 2 publications

References 99 publications

Chemometrics-Assisted UV-Vis Spectrophotometry for Quality Control of Pharmaceuticals: A Review

Chemometrics-Assisted UV-Vis Spectrophotometry for Quality Control of Pharmaceuticals: A Review

Survey of Ochratoxin A in coffee, dried grapes and grape pekmez samples in Burdur, Turkey

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