Occurrence and transfer characteristics of blaCTX-M genes among Escherichia coli in anaerobic digestion systems treating swine waste

Tian, Tiantian; Dai, Shiting; Liu, Dejun; Wang, Yan; Qiao, Wei; Yang, Min

doi:10.1016/j.scitotenv.2022.155321

Cited by 12 publications

(6 citation statements)

References 43 publications

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“…The remaining 18 ST types, comprising 25 E. coli strains, were found to be associated with bla CTX-M-55 for the first time, with ST6707 being detected in 6 stains. Previous reports have indicated that regions with a high detection rate of bla CTX-M often exhibited ST10 and ST48 as the most prevalent types ( He et al, 2021 ; Tian et al, 2022 ). In our study, ST10 was the most common type, while only one E. coli strain was identified as ST48.…”

Section: Resultsmentioning

confidence: 99%

“…Study shows that in 2019, cephalosporin-resistant Escherichia coli ( E. coli ) and Klebsiella pneumoniae resulted in tens of thousands of deaths ( Antimicrobial Resistance Collaborators, 2022 ). Meanwhile, the World Health Organization has classified third-generation cephalosporins as “highest-priority critically important antimicrobials” for human medicine ( Tian et al, 2022 ). Third-generation cephalosporins are widely used in food animals ( Hayer et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

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Implications of different waterfowl farming on cephalosporin resistance: Investigating the role of blaCTX-M-55

et al. 2023

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Implications of different waterfowl farming on cephalosporin resistance: Investigating the role of blaCTX-M-55

et al. 2023

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“…The resistance genes detected in the ESBL-EC isolates via PCR revealed that the CTX-M gene was the most prevalent β-lactam gene (23.3%; 7/30), which corresponds to the phenotypic resistance to the third and fourth generation cephalosporins. Usually, bla CTX-M genes are located on transferable plasmids, which could spread among animal, environmental and human E. coli isolates [ 31 ]. Regarding the genes associated with resistance to non-β-lactam antibiotics, tet A was the most prevalent gene in the ESBL-EC strains.…”

Section: Discussionmentioning

confidence: 99%

Extended-Spectrum β-Lactamase-Producing Escherichia coli Isolated from Food-Producing Animals in Tamaulipas, Mexico

Mandujano,

Cortés-Espinosa,

Vásquez-Villanueva

et al. 2023

Antibiotics

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Extended-spectrum β-lactamase (ESBL)-producing E. coli has become an important global problem for the public health sector. This study aims to investigate the E. coli antimicrobial resistance profile among living food-producing animals in Tamaulipas, Mexico. A total of 200 fecal samples were collected from bovines, pigs, chickens and sheep. A total of 5.0% of the strains were phenotypically confirmed as ESBL producers. A high percentage of phenotypic antimicrobial resistance was observed against gentamicin (93.3%), tetracycline (86.6%) and streptomycin (83.3%). The gentamicin-resistant strains showed MDR, distributed among 27 resistance patterns to different antimicrobials. The antimicrobial resistance gene tet(A) was detected in 73.3% of isolates, aadA1 in 60.0% and sul2 in 43.3% of strains. The blaCTX-M gene was found in 23.3% of strains. The virulence gene hlyA was detected in 43.3% of isolates; stx1 and stx2 were not detected in any strain. The phylotyping indicated that the isolates belonged to groups A (33.3%), B1 (16.6%), B2 (40.0%) and D (10.0%). These results show that food-producing animals might be a reservoir of ESBL-producing bacteria and may play a role in their spread.

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“…The abundance of ARGs in the biological treatment units could be reduced by >80%, and the biological wastewater treatment systems could be operated under stable conditions. In addition, hydrothermal treatment based on enhanced hydrolysis was also applied in Chinese full-scale plants for recycling waste erythromycin and cephalosporin fermentation residues (20). β Similarly, livestock waste is another major source of ARGs in the environment.…”

Section: Environmental Engineering Approaches and Practicesmentioning

confidence: 99%

“…Similarly, livestock waste is another major source of ARGs in the environment. Some prevalent high-risk ARGs in animal manure, such as CTX-M-type extended spectrum \begin{document}$\beta$\end{document} -lactamase genes ( bla CTX-M ), the ABC transporter gene conferring resistance to florfenicol and linezolid ( optrA ), and mobile tigecycline resistance gene [ tet (X) variants], were found to persist in animal manure, mesophilic anaerobic digestion and composting systems, and the related environment ( 21 - 23 ). Hyperthermophilic anaerobic treatment or composting could reduce the abundance of most high-risk ARGs and inactivate the fecal bacteria effectively, indicating that effective management of operating temperatures in anaerobic digestion or composting might be an effective way to prevent the discharge of the high-risk ARGs from animal manure treatment systems.…”

Section: Progress In the Containment Of Environmental Amr Developmentmentioning

confidence: 99%

Minimizing Risks of Antimicrobial Resistance Development in the Environment from a Public One Health Perspective

Walsh¹,

Wang²,

Shen³

et al. 2022

China CDC Weekly

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Antimicrobial resistance (AMR) is a globally recognized crisis with meaningful engagement across humans, animals, and the environment as in the One Health approach. The environment is the potential source, reservoir, and transmission route of AMR, and it plays a key role in AMR development from the One Health perspective. Animal farming, hospitals, and the pharmaceutical industry are identified as the main emission sources in the environment. Minimizing emissions and determining antimicrobial emission limits are priorities in the containment of environmental AMR development. From the perspectives of environmental management and environmental engineering, some important actions to minimize risks of AMR development are summarized, including the recent progress in enhanced hydrolysis pre-treatment technology to control the development of antibiotic resistance genes (ARGs) during biological wastewater treatment. It is desirable to establish a holistic framework to coordinate international actions on the containment of environmental AMR development. To establish a community with a shared future for humanity, China should and could play an important role in international cooperation to cope with AMR challenges. IDENTIFICATION OF MAIN EMISSION SOURCESNatural AMR is common among environmental bacteria, including in pristine locations relatively untouched by anthropogenic activities (5-7). However, the use of antimicrobial agents in humans China CDC Weekly Chinese Center for Disease Control and Prevention CCDC Weekly / Vol. 4 / No. 49 Action types Year Actions International actions 2013 Green procurement for pharmaceutical manufacturing (WHO and UNEP meeting) 2015 Global Action Plan on AMR (WHO) 2016 Creation of the AMR Industry Alliance 2017 Developing priorities for WHO activities on anti-microbial resistance and the environment (WHO expert meeting) 2018 List of antibiotic manufacturing discharge targets following the launch of the Common Antibiotic Manufacturing Framework (AMR Industry Alliance) 2019 Antibiotic use and wastewater residue (WHO expert meeting) 2020 Technical brief on water, sanitation, hygiene and wastewater management to prevent infections and reduce the spread of antimicrobial resistance (WHO/FAO/WOAH) 2022 Antibiotic manufacturing standards: Minimizing risk of developing antibiotic resistance and aquatic ecotoxicity in the environment resulting from the manufacturing of human antibiotics (AMR Industry Alliance) Actions of China 2002 Antibiotic fermentation residues were listed as prohibited drugs in forage and animal drinking water 2008 Antibiotic fermentation residues were officially included in Directory of National Hazardous Wastes in 2008 and remained in the revised versions in 2016 and 2021 2016 National action plan to contain antimicrobial resistance in China (2016-2020) 2017 Ministry of Agriculture and Rural Affairs of China formally banned colistin as an animal growth promoter 2019 Ministry of Agriculture and Rural Affairs withdrew all types of growth promoters from animal feed except Chinese ...

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Occurrence and transfer characteristics of blaCTX-M genes among Escherichia coli in anaerobic digestion systems treating swine waste

Cited by 12 publications

References 43 publications

Implications of different waterfowl farming on cephalosporin resistance: Investigating the role of blaCTX-M-55

Implications of different waterfowl farming on cephalosporin resistance: Investigating the role of blaCTX-M-55

Extended-Spectrum β-Lactamase-Producing Escherichia coli Isolated from Food-Producing Animals in Tamaulipas, Mexico

Minimizing Risks of Antimicrobial Resistance Development in the Environment from a Public One Health Perspective

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