Occurrence and removal of drugs and endocrine disruptors in the Bolonha Water Treatment Plant in Belém/PA (Brazil)

Teixeira, Luíza Carla Girard Mendes; Chaves, Juliane Ribeiro das; Mendonça, Neyson Martins; Sanson, Ananda Lima; Alves, Mariana C. P.; Afonso, Robson José de Cássia Franco; Aquino, Sérgio Francisco de

doi:10.1007/s10661-021-09025-x

Cited by 12 publications

(14 citation statements)

References 31 publications

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“…The detection of naproxen in Brazilian drinking water was reported by Brandt et al [65], Teixeira et al [66], Fazolo et al [67], and Alves et al [68]. Mean (8.091.0 ng/L) and median (48.3 ng/L) concentrations reported by Brandt et al [65] were generally lower than the GV calculated in this work (220,000 ng/L) (Table 3, Figure 2), except for an extreme value (372,632 ng/L) (Table 2) observed in Rio Grande do Norte state.…”

Section: Pandedc Exposure Via Drinking Water Consumptionmentioning

confidence: 81%

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Occurrence of Pharmaceuticals and Endocrine Disrupting Compounds in Brazilian Water and the Risks They May Represent to Human Health

Aquino

Brandt

Bottrel

et al. 2021

IJERPH

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The risks of pharmaceuticals and endocrine disrupting compounds (P&EDC) to the environment and human health are a current topic of interest. Hundreds of P&EDC may reach the environment, hence, there is a need to rank the level of concern of human exposure to these compounds. Thus, this work aimed at setting a priority list of P&EDC in Brazil, by studying their occurrence in raw and drinking water, calculating health guideline values (GV), and estimating the risks of population exposure to water intake. Data on the Brazilian pharmaceutical market as well as published data of the monitoring of Brazilian natural and drinking water have been collected by means of an exhaustive literature review. Furthermore, many foreign data were also collected to enable a comparison of the values found in Brazilian studies. A list of 55 P&EDC that have the potential to be found in Brazilian water is proposed, and for 41 of these a risk assessment was performed by estimating their margin of exposure (ME), by considering their occurrence in drinking water, and guideline values estimated from reported acceptable daily intake (ADI) data. For seven compounds the risk was deemed high (three estrogens and four anti-inflammatories), whereas for another seven compounds, it was regarded as an ‘alert’ situation. Although such risk analysis is conservative, since it has been calculated based on the highest reported P&EDC concentration in drinking water, it highlights the need to enhance their monitoring in Brazil to strengthen the database and support decision makers. An analysis of the occurrence of antimicrobial resistance agents (antibiotics, resistant bacteria, and resistance genes) in surface waters was also carried out and confirmed that such agents are present in water sources throughout Brazil, which deserves the attention of policy makers and health agents to prevent dissemination of antimicrobial resistance through water use.

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Section: Pandedc Exposure Via Drinking Water Consumptionmentioning

confidence: 81%

“…Dexamethasone has been monitored in several large cities of Brazil [65][66][67][68]. However, it was detected/quantified in drinking water only in the state of Paraná (in 31% of the samples), corresponding to 5% of all samples.…”

Section: Pandedc Exposure Via Drinking Water Consumptionmentioning

confidence: 99%

Occurrence of Pharmaceuticals and Endocrine Disrupting Compounds in Brazilian Water and the Risks They May Represent to Human Health

Aquino

Brandt

Bottrel

et al. 2021

IJERPH

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“…Data indicated that of the 24 microcontaminants studied, 10 were not detected in the FWW. Also, the compounds DCF, E3, LNZ, PNL, DTZ, DXM, and SMX were not detected in raw water arriving at Bolonha WTP, neither in the same dry season (2018) nor in the rainy (2019) (Teixeira et al, 2021). The acidity constant (pK a ) basic character of the analytes E3, PNL, DTZ, and DXM, drugs low sorption potential LNZ, PN, DTZ, DXM, and SMX, and the extraction of compounds in acidic pH = 2 are factors that can explain its non-detection in the FWW.…”

Section: Resultsmentioning

confidence: 96%

“…Microcontaminants can reach the environment through various routes, however, the main ones come from anthropic activities such as the release of sanitary effluents (treated or not), industrial and hospital effluents, sludge from wastewater treatment plants (WWTP), and water treatment plants (WTP), landfills and surface runoff, mainly from water resources (Bu et al, 2016;Souza, 2019). Published studies by Bila and Dezotti (2003), Sodré et al (2007), Montagner and Jardim (2011), Américo-Pinheiro et al (2017), Escher et al (2019), and Teixeira et al (2021) show the presence of several microcontaminants in raw and treated Brazilian surface waters, as well as a varied concentration of these compounds. There is also an increasing trend in the number of drugs detected in surface waters in several countries such as Spain (Mastroianni et al, 2016), Iraq (Al-Khazrajy and Boxall, 2016), Tanzania (Hossein et al, 2018), and Korea (Choi et al, 2008), among others.…”

Section: Introductionmentioning

confidence: 99%

Occurrence of drugs and endocrine disruptors in the filters washing water from a water treatment plant in Belém (PA), Brazil

Ferreira,

Teixeira,

Aquino

2023

Rev. Bras. Ciênc. Ambient.

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The present work aimed to investigate the occurrence of 24 drugs and endocrine disruptors in the filters washing water from the Bolonha Water Treatment Plant in Belém, State of Pará, Brazil, since these residues are often released into water courses. The correlation of these microcontaminants with physicochemical and biological characteristics investigated in the studied matrix was also evaluated. For the research, six sampling campaigns were carried out during the rainy season and six in the dry season. The compounds determination was performed by solid phase extraction and chromatography coupled to mass spectrometry, gas chromatography for Ibuprofen, Paracetamol, 4-Nonylphenol, 4-Octylphenol, Bisphenol A, Gemfibrozil, Estrone, Estradiol, Ethinylestradiol, and Estriol, and in liquid phase for the other compounds. The compounds detected at higher concentrations than the others were Losartan (5.5 to 738.7 ng/L) and Bisphenol A (20.9 to 518.9 ng/L), also with the highest frequency. Multivariate analyzes showed that drugs and endocrine disruptors were more positively related to each other and to turbidity during the rainy season, with emphasis on 4-Octylphenol, Bisphenol A, Losartan and Loratadine, results that strengthen the hypothesis of precipitation’s influence on the variables studied.

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“…). Although such pollutants are usually present in the environment in low concentrations, some of them are toxic per liter concentrations (Teixeira et al 2021). Their adverse effects leading to certain cancers and other non-communicable diseases such as diabetes and adverse effects on aquatic life populations have been reported (Olaniyan and Okoh 2020).…”

mentioning

confidence: 99%

A New Method for Environmental Risk Assessment of Pollutants Based on Multi-dimensional Risk Factors

Dong

Chen

et al. 2022

Preprint

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Deterioration of watershed environment and pollutant discharge had seriously threatened human health and ecosystem function. The importance of improving risk warning system is becoming more and more prominent. Traditional chemical risk assessment methods focused on toxicity and exposure of pollutants without considering the impact of persistent pollutants in different environmental media. So there are cases which pollutants that have been assessed as safe using these methods end up being classified as persistent organic pollutants. In this study we proposed a synthetical risk factor (SRF) analysis with multi-dimensional evaluation of pollutants. The new method integrated toxicity endpoint values, environmental exposure level, persistent properties and compartment features from various dimensions. Selected pesticides, perfluorinated compounds, organophosphate and endocrine disruptors were analyzed with both SRF and risk quotient (RQ) methods. The results showed, a higher risk outcome using SRF analysis for PFOS, imazalil, testosterone, androstenedione and bisphenol A, which were different from those obtained with RQ method but were consistent with existing risk management. The study demonstrated that SRF method improved risk assessment of various pollutants in surface water in a more robust fashion, and also provided a more accurate decision basis for ecological environment protection.

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Occurrence and removal of drugs and endocrine disruptors in the Bolonha Water Treatment Plant in Belém/PA (Brazil)

Cited by 12 publications

References 31 publications

Occurrence of Pharmaceuticals and Endocrine Disrupting Compounds in Brazilian Water and the Risks They May Represent to Human Health

Occurrence of Pharmaceuticals and Endocrine Disrupting Compounds in Brazilian Water and the Risks They May Represent to Human Health

Occurrence of drugs and endocrine disruptors in the filters washing water from a water treatment plant in Belém (PA), Brazil

A New Method for Environmental Risk Assessment of Pollutants Based on Multi-dimensional Risk Factors

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