Occurrence and lack of transmissibility of gonadal neoplasia in softshell clams, Mya arenaria, in Maine (USA) and Atlantic Canada

Barber, Bruce J.; MacCallum, G S; Robinson, Shawn; McGladdery, S. E.

doi:10.1016/s0990-7440(02)01186-5

Cited by 16 publications

(29 citation statements)

References 16 publications

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“…Some bivalves, like scallops or the oyster Crassostrea gigas and the blue mussel Mytilus edulis, seem to be more resistant to disseminated neoplasia than others, a finding which might point to a genetic background [61] . In the long-lived bivalves, like the ocean quahog A. islandica , tumors are rarely observed [65] and, so far, neoplasms have never been observed in M. margaritifera , which may point out another feature contributing to the extreme longevity of these species.…”

Section: Bivalves and Cancermentioning

confidence: 97%

Masters of Longevity: Lessons from Long-Lived Bivalves – A Mini-Review

2009

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The individual ages of bivalve molluscs can be inferred from the age rings laid down every year in the shell, especially in species inhabiting areas with seasonal variability in environmental factors such as food supply and temperature. Animals obtained from different environmental settings can therefore be used to investigate how specific environmental factors shape the process of ageing in this animal class. Some bivalves have extraordinary long life spans. Species like the ocean quahog Arctica islandica and the freshwater pearl mussel Margaritifera margaritifera live for over hundreds of years. Few studies so far have attempted to study the process of ageing, either specifically in long-lived bivalves or generally in very long-lived species. This review summarizes the current knowledge of cellular ageing in bivalves with a focus on the antioxidant system, as well as tissue repair and metabolic capacities of extremely long-lived species. We discuss the applicability of these animals as models for different ageing theories. We recommend a focus of future research on the molecular mechanisms potentially involved in supporting longevity in these species, including evolutionary old cellular mechanisms such as autophagy and apoptosis, as well as diverse cellular repair pathways.

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Section: Bivalves and Cancermentioning

confidence: 97%

Masters of Longevity: Lessons from Long-Lived Bivalves – A Mini-Review

2009

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“…The basophilic nuclei of these cells are often eccentric and the nucleolus is frequently difficult to distinguish in the abundantly clumped chromatin . In both species, neoplastic cells appear initially as small foci in one or more gonadal follicles, multiply to completely fill most or all follicles, and are capable of metastasis after invading interfollicular connective tissue, body wall, epibranchial chamber, and genital ducts; in advanced cases, normal gonadal architecture is destroyed (Hesselman et al, 1988;Gardner et al, 1991;Peters et al, 1994;Barber, 1996;Barber et al, 2002). Lesions contain cells with mitotic figures, pleomorphic mononucleated cells, and multinucleated giant cells Yevich, 1972, 1975;Hesselman et al, 1988;Barber, 1996).…”

Section: Descriptionmentioning

confidence: 99%

“…The probability of correctly diagnosing the presence of gonadal neoplasia (or any disease) increases with the severity of the disease. Three stages of severity were described for cases of gonadal neoplasia in M. arenaria (Barber, 1996;Barber et al, 2002). Stage 1 neoplasms consisted of undifferentiated germ cells partially or totally filling one or more (but less than half of the total) follicles; loss of gonadal architecture was rare.…”

Section: Diagnosismentioning

confidence: 99%

“…Germinomas have, however, reached high prevalences in populations of hard clams, Mercenaria spp. (Yevich and Barry, 1969;Barry and Yevich, 1972;Hesselman et al, 1988;Bert et al, 1993;Eversole and Heffernan, 1995;Arnold et al, 2002Arnold et al, , 2004; softshell clams, M. arenaria (Barry and Yevich, 1975;Gardner et al, 1991;Barber, 1996;Barber et al, 2002); and the blue mussel, M. galloprovincialis (Alonso et al, 2001;Ruiz et al, 2011Ruiz et al, , 2013c (Fig. 6).…”

Section: Epidemiologymentioning

confidence: 99%

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Neoplastic diseases of marine bivalves

Carballal

Barber

Iglesias

et al. 2015

Journal of Invertebrate Pathology

116

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“…These results suggest the mortality rate associated with gonadal neoplasia is higher in males who may succumb to the disease in its early stage. However Barber et al (2002) who investigated the prevalence of gonadal neoplasia in M. arenaria reported clam size and disease prevalence were not correlated. They further concluded that since the disease progresses slowly in M. arenaria, causing little mortality, there is a potential loss of reproductive output over the long term.…”

Section: Other Pathologies Observed In Arctica Islandicamentioning

confidence: 99%

Arctica islandica: the longest lived non colonial animal known to science

Ridgway

Richardson

2010

Rev Fish Biol Fisheries

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The ocean quahog, Arctica islandica is not just the longest living bivalve, it is also the longest lived, non-colonial animal known to science. With the maximum life span potential ever increasing and currently standing in excess of 400 years the clam has recently gained interest as a potential model organism for ageing research. This review details what is known about the biology of A. islandica, it discusses observed age-associated changes and reviews previous ageing research undertaken on the species and other long-lived bivalves which may be applicable to future ageing research and discusses future directions for ageing research with A. islandica. Historically much of the research on bivalves has been targeted at their utilization as a food source, environmental sentinels and more recently the use of their shells as archives of environmental change. The result of this has been an abundance of knowledge on bivalve life strategies, and a limited amount of information on the physiological changes in the cells and tissues of bivalves during the ageing process. However, research into the mechanisms of senescence of long-lived bivalves from a biogerontological perspective has advanced only recently. The research undertaken thus far has documented age-related differences in anti-oxidant defences and accumulation of oxidative products but despite the recent attention into ageing of A. islandica it is still to be ascertained if the species experiences senescence. Future directions for ageing research using A. islandica are discussed.

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Occurrence and lack of transmissibility of gonadal neoplasia in softshell clams, Mya arenaria, in Maine (USA) and Atlantic Canada

Cited by 16 publications

References 16 publications

Masters of Longevity: Lessons from Long-Lived Bivalves – A Mini-Review

Masters of Longevity: Lessons from Long-Lived Bivalves – A Mini-Review

Neoplastic diseases of marine bivalves

Arctica islandica: the longest lived non colonial animal known to science

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