Occupational opiate contact dermatitis

Morphine‐induced cutaneous adverse drug reaction following occupational diacetylmorphine contact dermatitis: A case report

“…Contact dermatitis and AGEP caused by diacetylmorphine and morphine have been reported before . Furthermore, the chemical similarities between morphine, diacetylmorphine and codeine are well known .…”

“…Contact dermatitis and AGEP caused by diacetylmorphine and morphine have been reported before. [1][2][3][4][5][6] Furthermore, the chemical similarities between morphine, diacetylmorphine and codeine are well known. 9 Thyssen and Maibach, along with Schnyder and Pichler, reviewed the possible pathomechanisms of systemic allergic dermatitis.…”

“…Contact dermatitis caused by diacetylmorphine (heroin) and by morphine have both been described before. [1][2][3][4][5] In addition, a case of acute generalized exanthematous pustulosis (AGEP) as a reaction to morphine has previously been described. 6 The present report describes a patient who was occupationally sensitized to diacetylmorphine, and developed a skin reaction after receiving morphine following surgery.…”

“…Contact dermatitis caused by diacetylmorphine (heroin) and by morphine have both been described before . In addition, a case of acute generalized exanthematous pustulosis (AGEP) as a reaction to morphine has previously been described .…”

Occupational allergic contact dermatitis caused by nalmefene

“…There are reports of sensitization and contact dermatitis following occupational exposure to phenanthrene alkaloid opiates and their derivatives 4 . Reactions have been reported to formulations of: codeine, codeine dihydrophosphate, ethylmorphine, morphine, diacetylmorphine, naloxone, oxycodone, thebaine, oripavine and norhydroxymorphinone 4‐9 . To our knowledge this is the first reported case of contact allergy to nalmefene.…”