Occupational mycosis fungoides – a case series

Slodownik, Dan; Moshe, Shlomo; Sprecher, Eli; Goldberg, Ilan

doi:10.1111/ijd.13589

Cited by 12 publications

(6 citation statements)

References 16 publications

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“…We have started from the idea that the etiology of mycosis fungoides has largely remained unknown and that all the environmental factors have been proposed. There are studies suggesting that many patients with mycosis fungoides have a chemical occupational exposure [10][11][12]. On the other hand, the carcinogenicity of asbestos exposure has been proven and all the asbestos varieties were classified as human carcinogens (group I) from IARC [15,16].…”

Section: Discussionmentioning

confidence: 99%

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Are there still other asbestos-related malignancies to be discovered?

Rașcu

Neicu

Oțelea

2018

Romanian Journal of Occupational Medicine

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Mycosis fungoides is one of the most common forms of cutaneous T-cell lymphoma. Its diagnosis is sometimes challenging and quite difficult for the physician, because its onset clinical appearance is similar to other skin diseases. Although there are a few hypotheses about mycosis fungoides’ etiology, they aren’t fully understood and still need confirmation. We report the case of a 68 years old patient diagnosed with mycosis fungoides, who has been exposed to asbestos fibers. This case is one of the few reported cases of association between asbestos and mycosis fungoides. There is no data exploring the causal relation between asbestos exposure and mycosis fungoides but common biological mechanisms could represent an argument. If occupational exposure to asbestos will be confirmed in larger studies, a new research-field of asbestos-related diseases needs to be opened.

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Section: Discussionmentioning

confidence: 99%

“…Workers in glass, paper and pulp industries, pottery, and ceramic factories carried the highest risk to develop mycosis fungoides [10]. The most associations were made with the following occupational exposures: aromatic hydrocarbons, hydrazine, halogenated hydrocarbons, formaldehyde and mustard gas [11,12].…”

Section: Doi: 102478/rjom-2018-0006mentioning

confidence: 99%

Are there still other asbestos-related malignancies to be discovered?

Rașcu

Neicu

Oțelea

2018

Romanian Journal of Occupational Medicine

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“…Our finding of significant HLA-DR5 and DQ-301 associations with MF also supports the possibility of antigen restriction [3] (MF. As in other non-Hodgkin lymphomas, increased rates of MF have also been reported in association with occupational exposures to Agent Orange, aromatic hydrocarbons, and pesticides [4,5]. There have also been several reports of non-random clustering of MF, which further implicate possible environmental or occupational exposure as triggers for MF [6][7][8].…”

Section: Introductionmentioning

confidence: 92%

Association of Flame-Retardant Clothing with Mycosis Fungoides: A Retrospective Analysis

Park

Ramachandran

Tran

et al. 2022

Dermatol Pract Concept

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Background: Mycosis fungoides (MF), the most prevalent form of cutaneous T-cell lymphoma (CTCL), has been associated with a variety of environmental and occupational exposures. Flame-retardant clothing (FRC), in contrast to flame-resistant clothing (FrC), is chemically treated and may constitute a previously unrecognized occupational hazard. Objective: To report an association between FRC and MF. Methods: After encountering several young male patients whose onset of MF coincided with the occupational use of FRC and occupation as fire fighters, we did a retrospective search. Additional biopsy proven MF patients with use of FRC were identified by the EPIC electronic medical record using the search terms “CTCL, mycosis fungoides, flame, and flame-retardant.” Results: Eight MF patients, all males, ranging in age from 31 years to 64 years (median age, 35 years) with exposure to FRC were identified. MF remission was noted in three patients who discontinued FRC use and in one patient who used a cotton undershirt barrier, while disease persistence was noted in one patient who continued to use FRC. Conclusions: FRC appears to be associated with development of MF through chronic antigen stimulation. Use of FRC is an occupational hazard for fire fighters. Any patient whose MF coincides with use of FRC should avoid further exposure through avoidance or switching to clothing made from inherently flame-resistant fibers.

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“…Regional variations in incidence of disease, geographic or familial (e.g. married couples) clustering, drug triggers (antihistamines, antiepileptics, anti hypertensives, SSRIs) [9] and occupational/ nutritional associations including exposure to aromatic hydrocarbons or vitamin D deficiency support an environmental role in the evolution of CTCL [10][11][12][13][14][15][16]. In some patients a shift of TH1 to Th2 cytokines may drive progression of CTCL in a positive feedback loop, e.g.…”

Section: Etiology/pathogenesismentioning

confidence: 99%

Cutaneous T-Cell Lymphoma

Sm¹

2015

Encyclopedia of Immunotoxicology

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Cutaneous T-cell lymphomas comprise a heterogeneous group of diseases characterized by monoclonal proliferations of T-lymphocytes primarily involving skin, modified skin appendages and some mucosal sites. This review addresses the basic clinical, histologic and immunohistochemical characteristics of this group of diseases, with additional attention to evolving literature on dermoscopy, reflectance confocal microscopy, flow cytometry and molecular data that may increasingly be applied to diagnostic and therapeutic algorithms in these diseases. Select unusual phenotypes, or diagnostic examples of classic phenotypes are demonstrated, and flags for consideration while making a pathologic diagnosis of CTCL are suggested.

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Occupational mycosis fungoides – a case series

Abstract: The clustering of two cases of MF, an exceptionally rare disease, in the same plant unit, as well as the long-term, intense occupational exposure in other cases, substantiates the notion that occupational exposures may contribute to the pathogenesis of MF.

Cited by 12 publications

References 16 publications

Are there still other asbestos-related malignancies to be discovered?

Are there still other asbestos-related malignancies to be discovered?

Association of Flame-Retardant Clothing with Mycosis Fungoides: A Retrospective Analysis

Cutaneous T-Cell Lymphoma

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