Occupational history and exposure and the risk of adult leukemia in Shanghai

Occupational exposure to pesticides and risk of hematopoietic cancers: meta-analysis of case–control studies

“…One study [31], was excluded because the data included unseparately both dead and living cases, one study [32], was excluded because data was not specifically limited to hematopoietic cancers, one study [33] was in Italian, 18 studies [9,[34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50] were eliminated because of insufficient data (number of cases or controls not provided, unclear results, unclear method used for the study, …), one study [51] was a review, one study [52] provided data included in another study [49] and one study included only accidental exposure of farm resident cases [53]. Overall, only 13 studies were included in our meta-analysis [3,12,[54][55][56][57][58][59][60][61][62][63][64] Some of these studies provided detailed data about type and level of exposure or type of pesticide used, we therefore had a total of 44 data (estimates of ORs) to include in our meta-analysis (Tables 1 and 2). Meta-analysis were first performed on all hematopoietic neoplasms pooling together all the 44 author's OR's in order to have a global idea about the overall effect then we did stratification analyses to study the correlation between professional exposure to pesticides and every type of cancer independently, citing non-Hodgk...…”

“…Most of the studies included in the analysis were restricted to non-Hodgkin lymphoma (six studies) [54-56, 58, 61, 62]. Two studies were restricted to multiple myeloma [12,57], two to myelodysplastic syndromes [3,63] and three to leukemia [59,60,64]. One study was restricted to females who had occupations with potential exposure to pesticides [54] four to male workers [3,55,56,57], five studies show data of both male and female workers [12,58,60,62,63] and two studies presented independent estimates of ORs and 95% CI according to the sex of the exposed person [59,61].…”

“…Two studies were restricted to multiple myeloma [12,57], two to myelodysplastic syndromes [3,63] and three to leukemia [59,60,64]. One study was restricted to females who had occupations with potential exposure to pesticides [54] four to male workers [3,55,56,57], five studies show data of both male and female workers [12,58,60,62,63] and two studies presented independent estimates of ORs and 95% CI according to the sex of the exposed person [59,61]. Among the included data (44 extracted estimates of risk assessment) (Tables 1 and 2), 66% (29 assessments) are from the USA [45][46][47][48][49][50], 14% (six assessments) are from Australia [52], 16% (seven assessments) are from Europe [51,44] and 4% from China (two assessments).…”

A systematic review of myeloid leukemias and occupational pesticide exposure

“…Those with data regarding the duration of employment were further classified as having worked in that occupation less than one year, or one year or more Adegoke et al [40]: for self-report of exposures, analyses were by ever exposed versus never exposed and by the total number of years spent on jobs with exposure, i.e., < 10 years, and ‡ 10 years number of events in each nosological category leading to non-significant and inconsistent results. The present study is, to our knowledge, the first metaanalytical approach to assess pesticide exposure as a potential occupational risk factor for adult myeloid leukemia.…”

“…Seventeen cohort studies [23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] and 16 case-control studies [40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55] were identified as fulfilling the inclusion criteria.…”