Occupational exposure to trichloroethylene and risk of non-Hodgkin lymphoma and its major subtypes: a pooled IinterLlymph analysis

Abstract

Our pooled analysis apparently supports the hypothesis of an increase in risk of specific NHL subtypes associated with occupational exposure to TCE.

Current status of development of methylation biomarkers for in vitro diagnostic IVD applications

“…The wide use of this substance makes it an occupational toxicant for various working groups. Moreover, TCE exposure has already been associated with kidney cancer [13][14][15][16], autoimmune diseases [17], and non-Hodgkin lymphoma [18][19][20]. Recent, epigenome-wide association study that included 37 and 30 workers exposed to high and low levels of this substance, respectively, and 73 unexposed controls identified 25 CpG sites with TCE-related methylation changes and a region in the promoter of TRIM68 gene that displayed hypomethylation with increased exposure to TCE.…”

Case-control investigation of occupational exposure to chlorinated solvents and non-Hodgkin’s lymphoma

“…Although our study and the two previous studies that considered subtype of NHL were underpowered to detect associations with individual subtypes, our observed carbon tetrachloride association with FL and MCL, and absence of an association with DLBCL and CLL/SLL, is not consistent with the findings from the previous studies 8 31. However, TCE exposure has been more strongly associated with FL in our study16 and in a pooled analysis of 3788 NHL cases and 4279 controls that included participants from our study 32…”

“…Use of specific chlorinated solvents for a given task has overlapped in various industries over time, and has complicated the interpretation of studies regarding the carcinogenicity of specific solvents 32. Our observed association between carbon tetrachloride and NHL remained on adjustment for exposure to TCE, thus arguing against confounding from this solvent as an explanation for our findings.…”

Trichloroethylene poses health risks, US EPA confirms

“…Data quality and inclusion/exclusion criteria screening identified ten studies suitable for use in metaanalysis. Of these, there were nine new studies with suitable informative data on the association of exposure to TCE and NHL (Bove et al, 2014a;Bove et al, 2014b;Christensen et al, 2013;Cocco et al, 2013;Hansen et al, 2013;Lipworth et al, 2011;Purdue et al, 2016;Silver et al, 2014;Vlaanderen et al, 2013), eight new studies with informative data for kidney cancer (Bove et al, 2014a;Buhagen et al, 2016;Christensen et al, 2013;Hansen et al, 2013;Lipworth et al, 2011;Purdue et al, 2016;Silver et al, 2014;Vlaanderen et al, 2013), and six new studies with informative data for liver cancer (Bove et al, 2014a;Christensen et al, 2013;Hansen et al, 2013;Lipworth et al, 2011;Silver et al, 2014;Vlaanderen et al, 2013). All of these studies scored Acceptable for data quality except (Bahr et al, 2011), which was excluded for scoring Unacceptable.…”