Case-control investigation of occupational exposure to chlorinated solvents and non-Hodgkin’s lymphoma

Callahan, Catherine L.; Stewart, Patricia A.; Friesen, Melissa C.; Locke, Sarah J.; Roos, Anneclaire J. De; Cerhan, James R.; Severson, Richard K.; Rothman, Nathaniel; Purdue, Mark P.

doi:10.1136/oemed-2017-104890

Cited by 10 publications

(5 citation statements)

References 28 publications

(16 reference statements)

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“…Of 78 chemicals in the NATA database, we identified 15 with plausible associations with human NHL or lymphoma in animal models; 6 of these chemicals were not included due to low cancer exposure risk estimates in the county databases (2,4‐toluene diisocyanate, coke oven emissions, hexachlorobenzene, methylene chloride, tetrachloroethylene and vinyl chloride), leaving 9 chemicals with reported associations with lymphoma for risk assessment: 1,3‐butadiene, 43 benzene, 44 chromium VI, 45 cadmium, 46 carbon tetrachloride, 47 ethylene oxide, 48 formaldehyde, 49 tetrachloroethylene 37 and polycyclic aromatic hydrocarbons 50 (Table 3). Cancer risk estimates were available in the NATA database for all but one county in the lymphoma case–control population.…”

Section: Resultsmentioning

confidence: 99%

Risk of bladder cancer and lymphoma in dogs is associated with pollution indices by county of residence

Smith

Luethcke

Craun

et al. 2021

Vet Comparative Oncology

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Human urothelial cell carcinoma (UCC) and non-Hodgkin lymphoma are considered environmental cancers in people, but less is known about environment risk for UCC and lymphoma in dogs. The objective of this study was to determine whether dogs with these cancers, compared to unaffected control dogs, live in counties with higher tap water contaminants or higher levels of air pollution as measured by the Environmental Protection Agency (EPA) and by National Air Toxics Assessment chemical exposure risk estimates. Dogs with available home addresses from two previously published case-control populations were included: 66 dogs with UCC and 70 unaffected controls; and 56 boxer dogs with lymphoma and 84 unaffected boxer controls. Tap water total trihalomethanes, which are water disinfection by-products, were more than threefold higher in UCC case counties of residence compared to controls (p < .0001), and a higher proportion of dogs with UCC lived in counties exceeding EPA ozone limits (41.8%) compared to controls (13.6% p = .0008). More boxers with lymphoma lived in counties exceeding EPA ozone limits (52.1%) compared to controls (29.0%; p = .018), with higher exposure risk estimates for airborne 1,3-butadiene and formaldehyde (p = .004-.005). These data support the hypothesis that tap water contaminants and airborne environmental pollutants contribute to the risk of both urothelial carcinoma and lymphoma in dogs. If these findings reflect causal relationships, then it is possible that tap water filtration units and more effective air pollution controls could decrease the overall incidence of these cancers in dogs.

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Section: Resultsmentioning

confidence: 99%

Risk of bladder cancer and lymphoma in dogs is associated with pollution indices by county of residence

Smith

Luethcke

Craun

et al. 2021

Vet Comparative Oncology

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“…Liu et al observed a pooled Odds Ratio for multiple myeloma of 2.04 (95% CI: 1.31-3.17) in relation to occupational exposure to methylene chloride but not for non-Hodgkin's lymphoma [13]. Thus, in an American case-control study involving 1189 NHL cases and 982 controls, exposure to chlorinated solvents (1,1,1,-trichloroethane, carbon tetrachloride, chloroform, methylene chloride and perchloroethylene) was evaluated and only an association between carbon tetrachloride exposure and NHL was evidenced [14]. Recent meta-analyses have found no association between benzene exposure and NHL occurrence [15,16].…”

Section: Discussionmentioning

confidence: 99%

Development of a Questionnaire for the Search for Occupational Causes in Patients with Non-Hodgkin Lymphoma: The RHELYPRO Study

Matrat

Gain

Haı̈oun

et al. 2021

IJERPH

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Non-Hodgkin lymphoma (NHL), multiple myeloma and chronic lymphocytic leukemia are possibly related to environmental and/or occupational exposure. The primary objective of this study was to develop a questionnaire for screening patients with these blood disorders who might benefit from a specialized consultation for possible recognition of the disease as an occupational disease. The study included 205 subjects (male gender, 67.3%; mean age, 60 years; NHL, 78.5%). The questionnaire performed very satisfactorily in identifying the exposures most frequently retained by experts for their potential involvement in the occurrence of NHL. Its sensitivity and specificity in relation to the final expertise were 96% and 96% for trichloroethylene, 85% and 82% for benzene, 78% and 87% for solvents other than trichloroethylene and dichloromethane, 87% and 95% for pesticides, respectively. Overall, 15% of the subjects were invited to ask National Social Insurance for compensation as occupational disease. These declarations concerned exposure to pesticides (64%), solvents (trichloroethylene: 29%; benzene: 18%; other than chlorinated solvents: 18%) and sometimes multiple exposures. In conclusion, this questionnaire appears as a useful tool to identify NHL patients for a specialized consultation, in order to ask for compensation for occupational disease.

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“…Our meta-estimate for five studies (Barry et al 2011;Callahan et al 2018;Cocco et al 2013;Miligi et al 2006;Seidler et al 2007) that examined exposure to chlorinated solvents and FL risk was 1.35 (95% CI=1.09, 1.68), with no statistical evidence of heterogeneity (I 2 =0.0%, p=0.702) (Table 1, Supplemental Fig. 13).…”

Section: Chlorinated Solventsmentioning

confidence: 90%

“…Carbon tetrachloride was examined by two case-control studies (19/889 cases exposed). Callahan et al (2018) assessed self-reported exposure in a US population-based case-control study and reported an increased risk associated with greater than median levels of exposure and no association with any exposure (Table 2, Fig. 5).…”

Section: Carbon Tetrachloridementioning

confidence: 99%

A systematic review and meta-analysis of occupational exposures and risk of follicular lymphoma

Odutola

Benke

Fritschi

et al. 2021

Environmental Research

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Case-control investigation of occupational exposure to chlorinated solvents and non-Hodgkin’s lymphoma

Cited by 10 publications

References 28 publications

Risk of bladder cancer and lymphoma in dogs is associated with pollution indices by county of residence

Risk of bladder cancer and lymphoma in dogs is associated with pollution indices by county of residence

Development of a Questionnaire for the Search for Occupational Causes in Patients with Non-Hodgkin Lymphoma: The RHELYPRO Study

A systematic review and meta-analysis of occupational exposures and risk of follicular lymphoma

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