Occupational Exposure to Solvents and the Risk of Lymphomas

Miligi, Lucia; Costantini, Adele Seniori; Benvenuti, Alessandra; Kriebel, David; Bolejack, Vanessa; Tumino, Rosario; Ramazzotti, Valerio; Rodella, Stefania; Stagnaro, Emanuele; Crosignani, Paolo; Amadori, Dino; Mirabelli, Dario; Sommani, Letizia; Belletti, Isabella; Troschel, Loredana; Romeo, Luciano; Miceli, Giuseppe; Tozzi, Giulio Andrea; Mendico, Igino; Víneis, Paolo

doi:10.1097/01.ede.0000231279.30988.4d

Cited by 81 publications

(73 citation statements)

References 43 publications

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“…At first, exposure to benzene was associated only with an increased risk of acute myeloid leukaemia (Hayes et al 1997), but the induction of NHL by benzene has now also become apparent (O'Connor et al 1999, Mehlman 2006, Miligi et al 2006, Smith et al 2007, Zhang et al 2007, Steinmaus et al 2008. Benzene induces NHL in experimental studies of mice and rats (Farris et al 1993, Huff et al 1989.…”

Section: Introductionmentioning

confidence: 99%

Urinary biomarkers suggest that estrogen-DNA adducts may play a role in the aetiology of non-Hodgkin lymphoma

Gaikwad¹,

Yang²,

Weisenburger³

et al. 2009

Biomarkers

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A variety of evidence suggests that estrogens may induce non-Hodgkin lymphoma (NHL). The reaction of catechol estrogen quinones with DNA to form depurinating estrogen-DNA adducts is hypothesized to initiate this process. These adducts are released from DNA, shed from cells into the bloodstream and excreted in urine. The aim of this study was to determine whether or not the depurinating estrogen-DNA adducts might be involved in the aetiology of human NHL. Estrogen metabolites, conjugates and depurinating DNA adducts were identified and quantified in spot urine samples from 15 men with NHL and 30 healthy control men by using ultraperformance liquid chromatography/tandem mass spectrometry. The levels of estrogen-DNA adducts were significantly higher in the men with NHL than in the healthy control men. Thus, formation of estrogen-DNA adducts may play a critical role in the aetiology of NHL, and these adducts could be potential biomarkers of NHL risk.

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Section: Introductionmentioning

confidence: 99%

Urinary biomarkers suggest that estrogen-DNA adducts may play a role in the aetiology of non-Hodgkin lymphoma

Gaikwad¹,

Yang²,

Weisenburger³

et al. 2009

Biomarkers

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“…8). For proxy respondents, we have evaluated the distribution of some confounding factors between direct responders and proxies.…”

Section: Resultsmentioning

confidence: 99%

“…The size of the control group was somewhat greater than the largest diagnostic group (NHL and chronic lymphocytic leukemia cases combined). Details on case ascertainment and recruitment and control sampling procedures have been described previously (8).…”

Section: Methodsmentioning

confidence: 99%

“…Organic solvents represent a class of chemicals that have been used in many industrial sectors, and exposure is also widespread among the general population. We have published in detail, elsewhere, the association between organic solvents and NHL, based on a large population-based multicenter case-control study in Italy (8). Solvents are suspected of exerting an immunotoxic effect (9).…”

Section: Introductionmentioning

confidence: 99%

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Exposure to Solvents and Risk of Non-Hodgkin Lymphoma: Clues on Putative Mechanisms

Víneis

Miligi²,

Costantini³

2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Malignant lymphomas are a group of diseases of uncertain etiology. Both environmental factors and genetic susceptibility have been reported as risk factors. We have conducted a population-based case-control study in Italy: all newly diagnosed cases of malignant lymphoma, in males and females ages 20 to 74 years in the 1991 to 1993 period, were identified; the control group was comprised of a random sample of the general population resident in each of the areas under study, stratified by sex and 5-year age groups. Overall, 1,428 non -Hodgkin lymphoma (NHL) cases and 1,530 controls were interviewed. Experts from each geographic area examined questionnaire data and assigned a level of probability and intensity of exposure to a range of chemical groups and individual chemicals. For those in the medium/high level of exposure, there was an increased risk of NHL for exposure to benzene, xylene, and toluene. We have examined the hypothesis that the effect of solvents is related to their immunotoxicity by analyzing the interaction with a previous history of autoimmune disease. We have found an apparent, though not statistically significant, increased risk of NHL in those with both exposure to benzene and a history of autoimmune disease (odds ratio, 16.3; 95% confidence interval, 0.8-321). In addition, an odds ratio of 29.8 (95% confidence interval, 1.4-650.2, based on nine exposed cases) was associated with high-level exposure to benzene in those with a positive family history of malignant hematologic neoplasms. Both hypotheses (i.e., the interaction with autoimmune diseases and with familial predisposition) indirectly suggest that an immunologic mechanism could be involved in lymphomagenesis from solvents. (Cancer Epidemiol Biomarkers Prev 2007;16(3):381 -4)

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“…The increased risk was found only for workers with an average exposure of 25 ppm benzene (RR = 4.7). Several other studies have reported an increased risk of non-Hodgkin lymphoma among workers occupationally exposed to benzene [157,[177][178][179] or to a mixture of organic solvents rather than benzene alone [177,180,181].…”

Section: Lymphomamentioning

confidence: 99%

Effects Of Benzene on Human Hematopoiesis

Kirkeleit¹,

Riise²,

Gjertsen³

et al. 2008

TOHJ

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Benzene, an aromatic hydrocarbon that is a natural component of crude oil and natural gas, is toxic to the blood and blood-forming organs. Epidemiological studies have established an association between benzene exposure and acute myeloid leukemia, and increasing evidence also indicates a possible association between benzene and multiple myeloma. A specific benzene-associated myelodysplastic syndrome has also been suggested. Chronic hematotoxic effects of benzene exposure, including reduced lymphocyte, neutrophil and platelet counts in peripheral blood, have been detected at occupational exposure below a level that had previously been considered not to cause any health effects. Whether these abnormalities represent bone marrow damage and/or initial events in the development of a true neoplastic disease is not known. Together with a reported nonlinear relationship between benzene exposure and the level of various metabolites, favoring production of biologically reactive quinones at exposure below 1 part per million, these observations suggest that benzene even at low exposure levels may contribute to the risk of acute myeloid leukemia or myelodysplastic syndrome, especially among genetically susceptible individuals.

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Occupational Exposure to Solvents and the Risk of Lymphomas

Abstract: This study suggests that aromatic and chlorinated hydrocarbons are a risk factor for non-Hodgkin lymphomas, and provides preliminary evidence for an association between solvents and Hodgkin disease.

Cited by 81 publications

References 43 publications

Urinary biomarkers suggest that estrogen-DNA adducts may play a role in the aetiology of non-Hodgkin lymphoma

Urinary biomarkers suggest that estrogen-DNA adducts may play a role in the aetiology of non-Hodgkin lymphoma

Exposure to Solvents and Risk of Non-Hodgkin Lymphoma: Clues on Putative Mechanisms

Effects Of Benzene on Human Hematopoiesis

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