Occupational exposure to pesticides and multiple myeloma in the AGRICAN cohort

Tual, Séverine; Busson, A; Boulanger, Mathilde; Renier, M.; Piel, Clément; Pouchieu, Camille; Pons, Romain; Perrier, Stéphanie; Levêque-Morlais, Noémie; Karuranga, Patrick; Lemarchand, Clémentine; AGRICAN-Group,; Marcotullio, Elisabeth; Guizard, Anne‐Valérie; Monnereau, Alain; Baldi, Isabelle; Lebailly, Pierre

doi:10.1007/s10552-019-01230-x

Cited by 14 publications

(25 citation statements)

References 32 publications

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“…Similar findings have been observed in the AGRIculture and CANcer (AGRICAN) study in France and among workers in the agricultural sector in Sweden (Lemarchand et al 2017;Lope et al 2008). The reasons for the excess of MM in farmers remain unclear, but exposure to pesticides is suspected to play a role (Lemarchand et al 2017;Lope et al 2008;Perrotta et al 2008Perrotta et al , 2013Tual et al 2019). Prior investigations in the AHS have noted significant exposure-response trends with MM risk for increasing exposure to the pyrethroid insecticide permethrin (Alavanja et al 2014;Rusiecki et al 2009), and several organochlorine insecticides have been associated with increased risk of lymphoid malignancies (a classification that includes MM) (Alavanja et al 2014).…”

Section: Introductionsupporting

confidence: 79%

Lifetime Pesticide Use and Monoclonal Gammopathy of Undetermined Significance in a Prospective Cohort of Male Farmers

Hofmann

Freeman

Murata

et al. 2021

Environ Health Perspect

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Section: Introductionsupporting

confidence: 79%

Lifetime Pesticide Use and Monoclonal Gammopathy of Undetermined Significance in a Prospective Cohort of Male Farmers

Hofmann

Freeman

Murata

et al. 2021

Environ Health Perspect

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“…A realização do levantamento dos estudos publicados, que associaram a exposição aos agrotóxicos com o desenvolvimento de LNH, resultou em 21 princípios ativos associados com o risco aumentado desse tipo de câncer (ALAVANJA et al, 2014;BLAIR;CANTOR;ZAHM, 1998;BONNER et al, 2007BONNER et al, , 2010CHIU et al, 2004;DE ROOS et al, 2003FISHER et al, 2020;FRITSCHI et al, 2005;HOAR et al, 1986;KACHURI et al, 2013;KOUTROS et al, 2019;LEON et al, 2019;LOUIS et al, 2017;MAHAJAN et al, 2007;MCDUFFIE et al, 2001;MILLS;YANG;RIORDAN, 2005;MOURA et al, 2020;NANNI et al, 1996NANNI et al, , 1998PARK et al 2009;PURDUE et al, 2007;RUSIECKI et al, 2009;TUAL et al, 2019) conforme observado na Figura 1.…”

Section: Análise Dos Agrotóxicos No Desenvolvimento De Lnhunclassified

“…Entre os agrotóxicos que se apresentaram com maior frequência nos artigos analisados, o Lindano foi o único composto pertencente ao grupo 1 (carcinogênico a humanos) da IARC. Em estudo realizado por Tual et al (2019), o uso de inseticidas organoclorados, como, Lindano e DDT, especialmente, em animais foi associado, positivamente, com Mieloma Múltiplo, um subtipo de LNH. Em outro estudo foi constatado que o uso constante de Lindano foi associado a riscos, signifi cativamente, aumentados de três subtipos de maioria destes agrotóxicos apresenta classificação pertencente a classe I (extremamente tóxico).…”

Section: Análise Dos Agrotóxicos No Desenvolvimento De Lnhunclassified

“…Várias exposições ambientais foram propostas e investigadas como possíveis causadoras do aumento do risco de câncer. Um dos tipos de câncer, que tem sido alvo dessa investigação é o Linfoma não Hodgkin (LNH) (ALAVANJA et al, 2014;KOUTROS et al, 2019;LEON et al, 2019;TUAL et al, 2019). O LNH é um grupo heterogêneo com mais de 20 tipos diferentes de doenças causadas pela proliferação de células (linfócitos) malignas do sistema linfático, que se espalham de maneira desordenada (INCA, 2018;RIEUTORT et al, 2016).…”

Section: Introductionunclassified

“…A associação entre LNH e exposição a agrotóxicos têm recebido grande foco nos estudos epidemiológicos, visto que o aumento da incidência e de mortalidade, ao longo dos anos de LNH, pode estar relacionado com o crescente aumento exponencial do uso de agrotóxicos. Estudos no Mundo todo têm demonstrado a relação do uso de agrotóxicos de diferentes classes funcionais com o aumento do risco de LNH (ALAVANJA et al, 2014;DREIHER;KORDYSH, 2006;TUAL et al, 2019).…”

Section: Introductionunclassified

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Identificação dos Agrotóxicos Associados ao Desenvolvimento de Linfoma Não-Hodgkin

et al. 2021

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A agricultura é uma das principais fontes antrópicas relacionadas com a contaminação ambiental. A quantidade de agrotóxicos utilizados nesta produção vem sendo aumentada ao longo dos anos em paralelo com o crescimento populacional. Os resíduos destes produtos contaminam o solo, o ar e a água e, com isso, apresentam risco direto ou indireto para a saúde humana e ambiental. A exposição humana aguda e crônica a estes compostos está relacionada com diversos efeitos negativos à saúde humana. O Linfoma não-Hodgkin (LNH) é um dos tipos de câncer mais associado com a exposição ocupacional aos agrotóxicos. De acordo com o levantamento de estudos realizados, neste trabalho, nos quais associaram a exposição aos agrotóxicos com LNH, 21 agrotóxicos foram identificados como associados com este tipo de câncer. Os agrotóxicos Ácido 2,4-diclorofenoxiacético, Diazinon, Diclorodifeniltricloroetano, Glifosato e Lindano foram os que apareceram em maior frequência nos artigos analisados e a associação destes compostos específicos com o risco aumentado de subtipos de LNH já foi relatada em estudos anteriores. Diante do que abordado, neste trabalho, a realização de estudos, que avaliem os riscos para o desenvolvimento de LNH causados pela exposição aos agrotóxicos se tornam necessários, a fim de contribuir com a prevenção de câncer para as populações expostas. Palavras-chave: Agricultura. Exposição Ocupacional. Inseticidas. Herbicidas. Câncer. Toxicidade. Abstract Agriculture is one of the main human sources related to environmental contamination. The amount of pesticides used in this production has been increasing over the years in parallel with the increase of population. The residues of these products contaminate the soil, air and water and, therefore, present a direct or indirect risk to human and environmental health. Acute and chronic human exposure to these compounds is related to several negative effects on human health, such as the development of cancer. Non-Hodgkin Lymphoma (NHL) is one of the types of cancer most associated with occupational exposure to pesticides. According to studies collected in this work, in which they associated exposure to pesticides with NHL, 21 pesticides were identified as associated with this type of cancer. The pesticides 2,4-dichlorophenoxyacetic acid, Diazinon, Dichlorodiphenyltrichloroethane, Glyphosate and Lindane were the ones that appeared with higher frequency in the analyzed articles and the association of these specific compounds with the increased risk of NHL subtypes has been reported in previous studies. Given what was addressed in this work, studies that assess the risks to NHL development caused by exposure to pesticides are necessary in order to contribute to cancer prevention in exposed populations. Keywords: Agriculture. Occupational Exposure. Insecticides. Herbicides. Cancer. Toxicity

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In vitro cytotoxicity and genotoxicity of single and combined pesticides used by Bolivian farmers

Cuenca

Galvão

Endirlik

et al. 2021

Environ and Mol Mutagen

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We previously showed that farmers in Bolivia are exposed to many pesticides, some at elevated levels, and that this was associated with increased risk of genetic damage. To improve the understanding of possible mixture effects, the cytotoxicity and genotoxicity of pesticides were studied in vitro using human liver HepG2 cells. The studied pesticides were 2,4‐D, chlorpyrifos, cypermethrin, glyphosate, methamidophos, paraquat, profenofos, and tebuconazole. Three mixtures (U1, U2, and U3) were based on profiles of urinary pesticide metabolites and one mixture on the most frequently used pesticides (S1). The results showed that paraquat and methamidophos were the most cytotoxic pesticides (EC50 ≤0.3 mM). Paraquat, chlorpyrifos, tebuconazole, and the U1, U2, and U3 mixtures, which contained a large proportion of either chlorpyrifos or tebuconazole, significantly increased intracellular ROS levels. Most pesticides activated DNA damage signaling through proteins Chk1 and H2AX. Strongest responses were elicited by paraquat, profenofos, chlorpyrifos, cypermethrin, and the S1 mixture, which contained 25% paraquat. Comet assay revealed significant increases of DNA damage in response to paraquat, cypermethrin, and U2 and S1 mixtures, which contained high levels of cypermethrin and paraquat, respectively. In summary, we showed that the tested pesticides, alone or in mixtures, in general induced oxidative stress and that most pesticides, and especially paraquat and cypermethrin, were genotoxic in HepG2 cells. We could also show that mixtures dominated by these two pesticides displayed a marked genotoxic potency, which agreed with our previous population studies.

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Occupational exposure to pesticides and multiple myeloma in the AGRICAN cohort

Cited by 14 publications

References 32 publications

Lifetime Pesticide Use and Monoclonal Gammopathy of Undetermined Significance in a Prospective Cohort of Male Farmers

Lifetime Pesticide Use and Monoclonal Gammopathy of Undetermined Significance in a Prospective Cohort of Male Farmers

Identificação dos Agrotóxicos Associados ao Desenvolvimento de Linfoma Não-Hodgkin

In vitro cytotoxicity and genotoxicity of single and combined pesticides used by Bolivian farmers

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