Lifetime Pesticide Use and Monoclonal Gammopathy of Undetermined Significance in a Prospective Cohort of Male Farmers

Hofmann, Jonathan N.; Freeman, Laura E. Beane; Murata, Kazunori; Andreotti, Gabriella; Shearer, Joseph J.; Thoren, Katie L.; Ramanathan, Lakshmi; Parks, Christine G.; Koutros, Stella; Lerro, Catherine C.; Liu, Danping; Rothman, Nathaniel; Lynch, Charles F.; Graubard, Barry I.; Sandler, Dale P.; Alavanja, Michael C.R.; Landgren, Ola

doi:10.1289/ehp6960

Cited by 18 publications

(11 citation statements)

References 45 publications

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“…The use of permethrin has been linked to the occurrence of multiple myeloma (50,51,55). Permethrin can act directly on the progression of the disease by having an immunomodulatory effect or, in the same way, lead to monoclonal gammopathy of undetermined significance, which increases the risk of developing multiple myeloma (109).…”

Section: Iarc Has Been Assessing the Carcinogenic Risk Of Pesticides ...mentioning

confidence: 99%

Monitoring residues of pesticides in food in Brazil: A multiscale analysis of the main contaminants, dietary cancer risk estimative and mechanisms associated

Valentim

Fagundes²,

Ferreira³

et al. 2023

Front. Public Health

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IntroductionPesticides pose a risk for cancer development and progression. People are continuously exposed to such substances by several routes, including daily intake of contaminated food and water, especially in countries that are highly pesticide consumers and have very permissive legislation about pesticide contamination as Brazil. This work investigated the relationship among pesticides, food contamination, and dietary cancer risk.MethodsAnalyzed two social reports from the Brazilian Government: the Program for Analysis of Residues of Pesticides in Food (PARA) and The National Program for Control of Waste and Contaminants (PNCRC).Results and discussionFirst, we characterized the main pesticide residues detected over the maximum limits allowed by legislation or those prohibited for use in food samples analyzed across the country. Based on this list, we estimated the dietary cancer risks for some of the selected pesticides. Finally, we searched for data about dietary cancer risks and carcinogenic mechanisms of each pesticide. We also provided a critical analysis concerning the pesticide scenario in Brazil, aiming to discuss the food contamination levels observed from a geographical, political, and public health perspective. Exposures to pesticides in Brazil violate a range of human rights when food and water for human consumption are contaminated.

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Section: Iarc Has Been Assessing the Carcinogenic Risk Of Pesticides ...mentioning

confidence: 99%

Monitoring residues of pesticides in food in Brazil: A multiscale analysis of the main contaminants, dietary cancer risk estimative and mechanisms associated

Valentim

Fagundes²,

Ferreira³

et al. 2023

Front. Public Health

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“…Additionally, the DR provided detail on individual foods consumed, classified by their eight-digit food code assigned by the United States Department of Agriculture (USDA). The first digit identifies the food group, as described in the USDA Food and Nutrient Database for Dietary Studies documentation 30 : (1) milk and milk products; (2) meat, poultry, fish, and mixtures; (3) eggs; (4) legumes, nuts, and seeds; (5) grain products; (6) fruits; (7) vegetables; (8) fats, oils, and salad dressings; and (9) sugars, sweets, and beverages. We divided (6) fruits into (6a) fruits (excluding juices) and (6b) fruit juices, and we created a combined "fruits (excluding juice) and vegetables" group.…”

Section: Descriptive Characteristics and Dietary Measuresmentioning

confidence: 99%

“…Risk factors for MGUS include older age 4 , male sex 4 , Black race 4 , family history 4 , chronic antigenic stimulation 5 , infections and inflammatory conditions 6 , certain pesticides 4, 7 , other chemicals 5 , diabetes 8 and obesity 9 . Obesity more than doubles the risk of progression from MGUS to MM 10 .…”

Section: Introductionmentioning

confidence: 99%

Dietary risk factors for monoclonal gammopathy of undetermined significance in a racially diverse population

Joseph,

Hillengass,

Tang

et al. 2023

Preprint

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Importance: Monoclonal gammopathy of undetermined significance (MGUS), a precursor condition of multiple myeloma, is associated with shorter lifespan and cardiac, renal, neurologic, and immune-related comorbidities. However, there is little known about modifiable risk factors, such as diet, for this condition. Objective: To determine if risk of MGUS is associated with dietary factors in a racially diverse population. Design: Case-control study based on the National Health and Nutrition Examination Survey (1988-2004). Setting: United States population-based study. Participants: 373 individuals whose sera met criteria for MGUS and 1,406 controls, randomly selected from 24,662 potential controls whose sera did not meet criteria for MGUS, matched 4:1 on age, sex, race, body mass index, and NHANES study cycle. Exposures: Diet was characterized by one 24-hour dietary recall, with gram intake of individual foods and beverages aggregated into groups. Unconditional multivariable logistic regressions were used to model associations between intake of several food groups and MGUS, with measures of association reported for the highest relative to the lowest quantile of intake. Main Outcomes and Measures: Odds ratios (OR) and 95% confidence intervals (95% CI) by quantile of gram intake of various food groups of interest. Results: The study included 1,779 participants, 55.0% non-Hispanic White, 57.6% male, with a mean (standard deviation) age of 67.3 (14.2) years. Daily intake of several food and beverage groups were significantly associated with MGUS. MGUS was inversely associated with whole-grain bread, oats, and rice (OR 0.70; 95% CI 0.48-1.00; P<0.05), fruits (excluding juice) and vegetables (OR 0.69; 95% CI 0.52-0.93; P=0.02), vegetables (OR 0.75; 95% CI 0.56-0.99; P<0.05), tomatoes (OR 0.72; 95% CI 0.51-1.00; P<0.05), and cruciferous vegetables (OR 0.44; 95% CI 0.26-0.74; P<0.01). Direct associations were observed for sugar-sweetened beverages (OR 1.34; 95% CI 1.00-1.78; P<0.05), sugar-sweetened soft drinks (OR 1.41; 95% CI 1.01-1.96; P=0.04), and artificially sweetened soft drinks (OR 1.55; 95% CI 1.04-2.33; P=0.03). Conclusions and Relevance: Our study shows that low intake of whole grains, fruits, and vegetables, and high intake of sweetened beverages, are associated with MGUS. The identification of dietary risk factors for MGUS in a diverse population is of direct public health relevance.

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“…40 Even pesticide use in agriculture has been associated with an increased risk of MGUS. 41,42 In an occupational health study from the Nordic countries, male and female farmers were the only population with an increased risk of MM (however relative risk of only 1.1). 43 Firefighters engaged in the containment of the World Trade Center attacks had a 2-fold increased risk of MGUS although other confounders cannot be excluded.…”

Section: Clinical Presentation Investigations and Stagingmentioning

confidence: 99%

“…The study was followed up by analysis of serum levels of microRNAs (miRNAs) in the exposed soldiers providing evidence on TCDD disrupted miRNA homeostasis 40 . Even pesticide use in agriculture has been associated with an increased risk of MGUS 41,42 . In an occupational health study from the Nordic countries, male and female farmers were the only population with an increased risk of MM (however relative risk of only 1.1) 43 .…”

Section: Epidemiology Of Myelomamentioning

confidence: 99%

Epidemiology, genetics and treatment of multiple myeloma and precursor diseases

Hemminki

Försti

Houlston

et al. 2021

Intl Journal of Cancer

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Multiple myeloma (MM) is a hematological malignancy caused by the clonal expansion of plasma cells. The incidence of MM worldwide is increasing with greater than 140 000 people being diagnosed with MM per year. Whereas 5-year survival after a diagnosis of MM has improved from 28% in 1975 to 56% in 2012, the disease remains essentially incurable. In this review, we summarize our current understanding of MM including its epidemiology, genetics and biology. We will also provide an overview of MM management that has led to improvements in survival, including recent changes to diagnosis and therapies. Areas of unmet need include the management of patients with high-risk MM, those with reduced performance status and those refractory to standard therapies. Ongoing research into the biology and early detection of MM as well as the development of novel therapies, such as immunotherapies, has the potential to influence MM practice in the future.

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Lifetime Pesticide Use and Monoclonal Gammopathy of Undetermined Significance in a Prospective Cohort of Male Farmers

Cited by 18 publications

References 45 publications

Monitoring residues of pesticides in food in Brazil: A multiscale analysis of the main contaminants, dietary cancer risk estimative and mechanisms associated

Monitoring residues of pesticides in food in Brazil: A multiscale analysis of the main contaminants, dietary cancer risk estimative and mechanisms associated

Dietary risk factors for monoclonal gammopathy of undetermined significance in a racially diverse population

Epidemiology, genetics and treatment of multiple myeloma and precursor diseases

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