Occupational exposure to metal compounds and lung cancer. Results from a multi-center case–control study in Central/Eastern Europe and UK

Mannetje, Andrea ’t; Bencko, Vladimír; Brennan, Paul; Заридзе, Давид; Szeszenia-Da̧browska, Neonila; Rudnai, Péter; Lissowska, Jolanta; Fabiánovà, Eleonóra; Cassidy, Adrian; Mateș, Dana; Foretová, Lenka; Janout, Vladimí­r; Févotte, Joëlle; Fletcher, Tony; Boffetta, Paolo

doi:10.1007/s10552-011-9843-3

Cited by 21 publications

(19 citation statements)

References 23 publications

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“…Whereas occupational exposure is well-described risk factor for arsenic and cadmium exposure; there was no found a relation between occupational history and metal levels of cases in this study, this result may be related with any cases had occupational history including arsenic and/or cadmium poisoning (23).…”

Section: Discussioncontrasting

confidence: 75%

The evaluation of arsenic and cadmium levels in biological samples of cases with lung cancer

Demir

Türksoy²,

Kayaaltı³

et al. 2014

Tuberk Toraks

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The evaluation of arsenic and cadmium levels in biological samples of cases with lung cancer Introduction: Chronic exposure to the toxic metals plays an important role among the causes of lung cancer beside of smoking We g. aimed to evaluate the association between the histopathologic type of lung cancer and arsenic and cadmium levels in biological samples. mp Materials and Methods: This study in a single center was conducted through the years 2009-2013, including 72 patients with lung l cancer, within a prospective study design. Biological samples (whole blood, scalp hair, urine) of subjects obtained before the treat-tr ment, and arsenic and cadmium levels were analyzed by atomic absorption spectrophotometer. The characteristics of lung cancer an cases and metal levels were compared statistically (power: 0.74).

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Section: Discussioncontrasting

confidence: 75%

The evaluation of arsenic and cadmium levels in biological samples of cases with lung cancer

Demir

Türksoy²,

Kayaaltı³

et al. 2014

Tuberk Toraks

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“…Another way of obtaining better agreement could be to use 10–15 benchmarks in terms of occupational titles representing specific job groups, which the experts consensus rated before the remaining rating process. In this way the experts could calibrate their estimates to a common scale [17,28,45]. …”

Section: Discussionmentioning

confidence: 99%

An expert-based job exposure matrix for large scale epidemiologic studies of primary hip and knee osteoarthritis: The Lower Body JEM

Rubak

Svendsen

Andersen

et al. 2014

BMC Musculoskelet Disord

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BackgroundWhen conducting large scale epidemiologic studies, it is a challenge to obtain quantitative exposure estimates, which do not rely on self-report where estimates may be influenced by symptoms and knowledge of disease status. In this study we developed a job exposure matrix (JEM) for use in population studies of the work-relatedness of hip and knee osteoarthritis.MethodsBased on all 2227 occupational titles in the Danish version of the International Standard Classification of Occupations (D-ISCO 88), we constructed 121 job groups comprising occupational titles with expected homogeneous exposure patterns in addition to a minimally exposed job group, which was not included in the JEM. The job groups were allocated the mean value of five experts’ ratings of daily duration (hours/day) of standing/walking, kneeling/squatting, and whole-body vibration as well as total load lifted (kg/day), and frequency of lifting loads weighing ≥20 kg (times/day). Weighted kappa statistics were used to evaluate inter-rater agreement on rankings of the job groups for four of these exposures (whole-body vibration could not be evaluated due to few exposed job groups). Two external experts checked the face validity of the rankings of the mean values.ResultsA JEM was constructed and English ISCO codes were provided where possible. The experts’ ratings showed fair to moderate agreement with respect to rankings of the job groups (mean weighted kappa values between 0.36 and 0.49). The external experts agreed on 586 of the 605 rankings.ConclusionThe Lower Body JEM based on experts’ ratings was established. Experts agreed on rankings of the job groups, and rankings based on mean values were in accordance with the opinion of external experts.

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“…These elements often include toxic heavy metals, especially arsenic (As), cadmium (Cd), chromium (Cr), nickel (Ni), and lead (Pb) (Mu et al, 2012;Passant et al, 2002). The carcinogenic potential of these heavy metals has been widely Contents lists available at ScienceDirect journal homepage: www.elsevier.com/locate/envres studied in humans and experimental animals ('t Mannetje et al, 2011;Boffetta et al, 2011;Huang et al, 2004;Joseph, 2009;O'Brien et al, 2003;Oller, 2002;Verougstraete et al, 2003). The unifying factor in determining toxicity and carcinogenicity for all these metals is the generation of free radicals and oxidative stress, which can then cause oxidative damage to DNA and enhanced lipid peroxidation (Jeng et al, 2011;Valko et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

The effects of heavy metals and their interactions with polycyclic aromatic hydrocarbons on the oxidative stress among coke-oven workers

Wang

Feng

Kuang

et al. 2015

Environmental Research

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Occupational exposure to metal compounds and lung cancer. Results from a multi-center case–control study in Central/Eastern Europe and UK

Abstract: Occupational exposure to metals is an important risk factor for lung cancer. Although the strongest risk was observed for arsenic, exposure to chromium dust was most important in terms of attributable risk due to its high prevalence.

Cited by 21 publications

References 23 publications

The evaluation of arsenic and cadmium levels in biological samples of cases with lung cancer

The evaluation of arsenic and cadmium levels in biological samples of cases with lung cancer

An expert-based job exposure matrix for large scale epidemiologic studies of primary hip and knee osteoarthritis: The Lower Body JEM

The effects of heavy metals and their interactions with polycyclic aromatic hydrocarbons on the oxidative stress among coke-oven workers

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