“…The International Agency for Research on Cancer (IARC) has classified many antineoplastic agents as class 1 human carcinogens (eg, cyclophosphamide, etoposide, busulfan, melfalan), class 2A probably carcinogenic to humans (eg, azacitidine, cisplatin, doxorubicine) or class 2B possibly carcinogenic to humans (bleomycin, dacarbazine, mitoxantrone, mitomycin) (20). Occupational exposure to antineoplastic agents has been shown to result in an increased frequency of total chromosomal aberrations (CATot) in PBL, as documented by a number of studies (2,(21)(22)(23)(24)(25)(26). Interestingly, nurses occupationally exposed to antineoplastic drugs showed an elevated level of not only chromatid-type aberrations (CTA) (induced by most chemical clastogens), but also chromosome-type aberrations (CSA), such as chromosome breaks and dicentric chromosomes, which is typical of radiation exposure (23).…”