Polymorphisms of glutathione S-transferases M1, T1, P1 and A1 genes in the Tunisian population: An intra and interethnic comparative approach

Salah, Ghada Ben; Kallabi, Fakhri; Maatoug, S.; Mkaouar-Rebai, Emna; Fourati, Amine; Fakhfakh, Faiza; Ayadi, Habib; Kamoun, Hassen

doi:10.1016/j.gene.2012.01.054

Cited by 22 publications

(15 citation statements)

References 40 publications

(56 reference statements)

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“…In conclusion, the data of seven patterns for GST M1-T1 null allele frequency from Xhosa tribe (I), Zimbabwe (II), Ethiopia (III), Egypt (IV), Afghanistan (V), Caucasian (VI) and South Indian Andhra Pradesh (VII) reported in this study compare constructively with the earlier studies that suggested the PAs of relatively recent origin show comparatively small genetic differences and high genetic affinity among them [11, 46, 52, 58]. Findings of these seven patterns (I-VII) for GST M1-T1 null allele frequency reported here, would shed some light to address the missing link in most of the genomic epidemiological studies that lacks conclusive risk association [9, 16, 17]. The “Africa” (I), “Out of Africa” (II, III and IV) and “Other than Africa” (V, VI and VII) split among the 45 GAHPs reported in this study have to be explored further to rationalize the GST M1-T1 null allele’s frequency patterns in world populations.…”

Section: Discussionsupporting

confidence: 86%

“…To address the extent of diversity in allele frequency distribution among populations from different ethnicity, region, country or continent is difficult, nevertheless understanding this phenomenon is inevitable [8, 11, 16, 17] and recent advances in the molecular techniques excel the perspective of inter-individual genetic variations in GAHPs. Allele frequencies of large number of neutral markers or of even few candidate markers that duplicate or decay to favor new environments and lead to rapid adaptations are often used for investigating the patterns [58].…”

Section: Discussionmentioning

confidence: 99%

“…Recent advances in molecular techniques have opened a new era of pharmacogenomics and several researchers are inclined towards investigating the relationship in genetic diversity and allelic frequency of GST classes to insight genetic predisposition or susceptibility among various ethnics or PAs. In this context, probing the genetic variation in GST classes is inevitable for genomic epidemiological studies and to develop new common drugs in future to majority of PAs [9, 16, 17]. The allele frequency pattern in GST M1-T1 null genotypes of different PAs are yet to be explored to unlock several phenomenons related to a risk association with genetic diseases and drug dispositions [10].…”

Section: Introductionmentioning

confidence: 99%

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GST M1-T1 null Allele Frequency Patterns in Geographically Assorted Human Populations: A Phylogenetic Approach

et al. 2015

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Genetic diversity in drug metabolism and disposition is mainly considered as the outcome of the inter-individual genetic variation in polymorphism of drug-xenobiotic metabolizing enzyme (XME). Among the XMEs, glutathione-S-transferases (GST) gene loci are an important candidate for the investigation of diversity in allele frequency, as the deletion mutations in GST M1 and T1 genotypes are associated with various cancers and genetic disorders of all major Population Affiliations (PAs). Therefore, the present population based phylogenetic study was focused to uncover the frequency distribution pattern in GST M1 and T1 null genotypes among 45 Geographically Assorted Human Populations (GAHPs). The frequency distribution pattern for GST M1 and T1 null alleles have been detected in this study using the data derived from literatures representing 44 populations affiliated to Africa, Asia, Europe, South America and the genome of PA from Gujarat, a region in western India. Allele frequency counting for Gujarat PA and scattered plot analysis for geographical distribution among the PAs were performed in SPSS-21. The GST M1 and GST T1 null allele frequencies patterns of the PAs were computed in Seqboot, Gendist program of Phylip software package (3.69 versions) and Unweighted Pair Group method with Arithmetic Mean in Mega-6 software. Allele frequencies from South African Xhosa tribe, East African Zimbabwe, East African Ethiopia, North African Egypt, Caucasian, South Asian Afghanistan and South Indian Andhra Pradesh have been identified as the probable seven patterns among the 45 GAHPs investigated in this study for GST M1-T1 null genotypes. The patternized null allele frequencies demonstrated in this study for the first time addresses the missing link in GST M1-T1 null allele frequencies among GAHPs.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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GST M1-T1 null Allele Frequency Patterns in Geographically Assorted Human Populations: A Phylogenetic Approach

et al. 2015

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“…In contrast, significant differences (p < 0.05) were observed for the frequency of GSTM1 (51%) null genotype with Africans or Afro-descendant populations. Moreover, the frequency of GSTT1-null variant in our admixed sample (11%) was similar to other admixed Latin American populations [39,40] but lower when compared with those in other studies conducted in Caucasians, Africans, and Asians [41][42][43][44].…”

Section: Genesupporting

confidence: 86%

Genomic biomarkers related to drug response in Venezuelan populations

Chiurillo

2014

Drug Metabolism and Personalized Therapy

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Pharmacogenetics is being applied to develop individual specific therapies considering different ethnic groups and mixed populations. The Venezuelan population is very heterogeneous as a result of the admixture process that occurred between Native Americans, Europeans, and Africans through five centuries. This review provides a summary of the literature concerning gene variants within drug-metabolizing enzymes, drug targets, and drug receptors (CYP2C19, CYP2D6, GSTM1, GSTT1, GSTP1, NAT2, MTHFR, LEP, LEPR, LTC4S, and ADRβ2 genes) evaluated in the Venezuelan population. In particular, most of the studies were conducted with relatively low numbers of individuals. Some of these studies included analyses of genetic polymorphisms in native groups living in this country. Although the recent studies represent a hopeful progress toward the inclusion of the Venezuelan population among those who will benefit from the implementation of pharmacogenetic principles and tools in drug therapy, there are not yet sufficient data concerning allelic frequencies of genomic biomarkers related to drug response for their implementation in clinical practice. Therefore, there is a critical need for more research in pharmacogenetics in Venezuela to increase data availability.

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“…GST null genotypes among smokers showed no influence in cervical lesion, despite GSTM1 and GSTT1 are involved in detoxification of carcinogens of tobacco (Salah et al 2012). Our study was similar to a study conducted in northern India by Singh et al (2008).…”

Section: Characteristics Of Womensupporting

confidence: 86%

Association Between Glutathione S-Transferase Genotypes, Human Papillomavirus Infection and Development of Cervical Injury in Olinda -Pe

Soares¹,

Martins²,

Medeiros³

et al. 2013

VR&R

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Human papillomavirus (HPV) is responsible for developing cancers, among them cervical cancer, which is the second cancer responsible for female mortality. The polymorphism of glutathione S-transferase (GST) is closely linked to an increased risk of cervical lesions and HPV infection. This enzyme is involved in phase II of xenobiotic metabolism, which can eliminate potential toxic carcinogenic compounds from the body. In this study, it was analysed the association between GSTM1 and/or GSTT1 polymorphism and susceptibility to HPV infection or development of cervical lesions. It was also analysed the correlation of these polymorphisms with external factors such as number of sexual partners, parity, smoking and alcohol consumption. Women who had more than one sexual partner presented 2.35 times more chances of being infected by HPV, but it could not be associated to the development of cervical lesions. However, more than three pregnancies leads to high risk (OR=3.2) of developing cervical lesions. Considering the genotypes analyzed in this study, only GSTT1 null showed significant influence on the risk of HPV infection among consumers of alcohol (OR=6.6) and none of them showed influence on the risk of developing cervical lesions (P <0.05). The study of other polymorphisms and expression of GST isoforms and enzymes that act in phase I of xenobiotics metabolism, for example, could lead to further clarification of the effect of oxidative stress on cellular susceptibility to HPV infection, since the results this research point to this interaction.

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Polymorphisms of glutathione S-transferases M1, T1, P1 and A1 genes in the Tunisian population: An intra and interethnic comparative approach

Cited by 22 publications

References 40 publications

GST M1-T1 null Allele Frequency Patterns in Geographically Assorted Human Populations: A Phylogenetic Approach

GST M1-T1 null Allele Frequency Patterns in Geographically Assorted Human Populations: A Phylogenetic Approach

Genomic biomarkers related to drug response in Venezuelan populations

Association Between Glutathione S-Transferase Genotypes, Human Papillomavirus Infection and Development of Cervical Injury in Olinda -Pe

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