Occupational contact dermatitis caused by sodium cocoamphopropionate in a liquid soap used in fast‐food restaurants

Occupational contact allergy to sodium cocoamphopropionate in a skin protection cream

“…These substances are widely used as surfactants and as foaming and cleansing agents, mainly in cosmetic products, because of their good toxicological characteristics and their mild irritation potential, for example in comparison with anionic surfactants (–). Seven cases of occupational contact allergy to sodium cocoamphopropionate in a disinfecting hand cleanser (Sensisept H34®) in Finnish and Swedish workers have been published (, ). Only a few cases of occupational contact allergy to other imidazoline‐derived amphoteric surfactants have been reported (, ).…”

Occupational contact allergy to sodium cocoamphopropionate in a hand cleanser

“…Two cases of occupational contact dermatitis in fast-food restaurant workers caused by sodium cocoamphopropionate in disinfectant hand cleanser have been recently reported in Sweden (1). We report 5 cases of occupational contact dermatitis caused by sodium cocoamphopropionate in the same hand cleanser product.…”

“…. It has been suggested that the amphoacetates themselves may not be contact allergens, but that the actual allergen might be an impurity, raw material or side product of the amphoacetate synthesis . AEEA, one of the reagents used in the synthesis of amphoacetates, was proposed as a possible allergen in detergents containing amphoacetates .…”

New Cosmetic Contact Allergens

“…Alkyl glucosides, such as coco and lauryl glucosides, emulsifiers and mild surfactants, and decyl glucoside that is associated with the sunscreen agent Methylene Bis-Benzotriazolyl Tetramethylbutyl-phenol, have been repeatedly reported as cosmetic allergens as well (see [51] for a review). Another mild surfactant reported is sodium cocoamphopropionate [52] that is closely related to sodium cocoamphoacetate [53]. Humectants such as butylene-, pentylene-, and hexylene-glycol, i.e., aliphatic alcohols with similar uses (solvent, humectant and antibacterial) to propylene glycol that is considered to be more irritant and allergenic, have become very popular in recent years.…”