Occupational conjunctivitis caused by sensitization to Anisakis simplex

Añíbarro, B.; Seoane, F. J.

doi:10.1016/s0091-6749(98)70108-3

Cited by 35 publications

(23 citation statements)

References 4 publications

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“…In other countries, where Pseudoterranova is more frequent (such as the United States), perhaps this parasite's allergens should be tested for when testing for fish allergy. As far as the occupational aspect is concerned, there are reports from the Basque Country (27), other regions of Spain (12,17,220), Italy (221), and South Africa (201).…”

Section: Human Susceptibility Factorsmentioning

confidence: 99%

“…Alarmingly, some episodes of allergy have been described in association with exposure to even very small doses of A. simplex antigens and without the involvement of living parasites: two episodes of anaphylaxis have been reported in direct association with skin prick testing using an A. simplex extract (25,50). It has also been reported that A. simplex allergy behaves as other severe food allergies in that it can be provoked by skin contact or inhalation of minute quantities of the allergen (258), causing occupational hazards such as conjunctivitis (12) and asthma (17,220,241), protein contact dermatitis, and conjunctivitis (51,61). More recently, a cross-sectional epidemiologic analysis of South African fish-processing workers revealed a high prevalence (8%) of sensitization to A. simplex (higher than sensitization to fish) associated with dermatitis and nonspecific bronchial hyperreactivity (201).…”

Section: Introductionmentioning

confidence: 99%

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Anisakis simplex: from Obscure Infectious Worm to Inducer of Immune Hypersensitivity

2008

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SUMMARY Infection of humans with the nematode worm parasite Anisakis simplex was first described in the 1960s in association with the consumption of raw or undercooked fish. During the 1990s it was realized that even the ingestion of dead worms in food fish can cause severe hypersensitivity reactions, that these may be more prevalent than infection itself, and that this outcome could be associated with food preparations previously considered safe. Not only may allergic symptoms arise from infection by the parasites (“gastroallergic anisakiasis”), but true anaphylactic reactions can also occur following exposure to allergens from dead worms by food-borne, airborne, or skin contact routes. This review discusses A. simplex pathogenesis in humans, covering immune hypersensitivity reactions both in the context of a living infection and in terms of exposure to its allergens by other routes. Over the last 20 years, several studies have concentrated on A. simplex antigen characterization and innate as well as adaptive immune response to this parasite. Molecular characterization of Anisakis allergens and isolation of their encoding cDNAs is now an active field of research that should provide improved diagnostic tools in addition to tools with which to enhance our understanding of pathogenesis and controversial aspects of A. simplex allergy. We also discuss the potential relevance of parasite products such as allergens, proteinases, and proteinase inhibitors and the activation of basophils, eosinophils, and mast cells in the induction of A. simplex-related immune hypersensitivity states induced by exposure to the parasite, dead or alive.

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Section: Human Susceptibility Factorsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anisakis simplex: from Obscure Infectious Worm to Inducer of Immune Hypersensitivity

2008

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“…Both routes of sensitization primed mice to exhibit allergic airway inflammation after subsequent intranasal challenge with an Anisakis extract. This finding is important, because it strongly suggests that repeated inhalation of aerosolized Anisakis proteins is able to cause respiratory reactions, as suggested by previous studies of humans (1,3,37). This is particularly relevant for food-and work-related allergies in exposed individuals.…”

Section: Discussionmentioning

confidence: 54%

“…This is an important clinical question in view of the fact that several case and prevalence studies, including ours, indicate that sensitization by inhalation of Anisakis proteins might be an important cause of work-related allergies (1,3,7,37,39,40). Aerosolized food allergens cause as much as 10% of asthma in the occupational environment (41), and Anisakis allergens aerosolized during fish cleaning, cooking, or fish meal production may therefore pose a risk for workers.…”

mentioning

confidence: 85%

Anisakis pegreffii-Induced Airway Hyperresponsiveness Is Mediated by Gamma Interferon in the Absence of Interleukin-4 Receptor Alpha Responsiveness

et al. 2010

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“…La larva móvil puede penetrar la pared intestinal, invadir y llegar al hígado, bazo, páncreas 30 , pulmones 31 y ovario. Se ha asociado a conjuntivitis, faringitis recurrente y adenopatías mesentéricas 23,[32][33] . Tanto anisakidosis como pseudoterranovosis se presentan predominantemente en adultos, con escasos reportes en Pediatría 34 .…”

Section: Parasitologíaunclassified

Pseudoterranovosis y sushi

et al. 2008

Rev. chil. infectol.

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A case of accidental ingestion of Pseudoterranova decipiens is reported, on account of this patient we review main concepts related to this emerging pathology in Chile. Consumption of raw fish in different preparations such as sushi or sashimi, cebiche and seafood is becoming more and more popular. Through intermediary hosts used in the preparation, one can acquire the third stage larval of Anisakis simplex or P. decipiens. These parasites frequently cause gastritis, acutely after the consumption of raw fish, or more rarely intestinal involvement. It may also cause allergic symptoms such as urticaria, angioedema and anaphylactic shock. The larvae is eliminated spontaneously in most cases; others need to be removed by upper gastrointestinal endoscopic examination. In Chile, the most common species is P. decipiens, which are generally no invasive, rarely migrate beyond the stomach and cause mild or no symptoms. Prevention strategies include avoid eating raw fish or undercooked seafood containing the parasite, to cook food with high temperatures or to freeze raw fish prior to preparation of meals, which inactivates the larvae.Key words: Anisakidosis, anisakiosis, pseudoterranovosis, Anisakis simplex, Pseudoterranova decipiens, foodborne parasitic infections, fishborne parasitic infections, zoonoses.Palabras clave: anisakidosis, anisakiosis, pseudoterranovosis, Anisakis simplex, Pseudoterranova decipiens, enfermedades parasitarias transmitidas por alimentos, enfermedades parasitarias transmitidas por peces y mariscos, zoonosis. Introduccióne estima que las infecciones parasitarias transmitidas por alimentos afectan a más de 50 millones de personas en el mundo, cifra probablemente sub-estimada por la dificultad en el diagnóstico y una sub-notificación. La mayor incidencia de estas infecciones se encuentra en el Este y Sudeste asiático, situación que se está haciendo cada vez más frecuente en nuestro medio con los viajes a destinos exóticos y la incorporación de la comida oriental a los menús tradicionales. Las infecciones parasitarias son el resultado de la ingesta de alimentos crudos o mal cocidos. Comentario editorial en página 196. La mayoría de estos cuadros son producidos por nemátodos, tremátodos, céstodos y protozoos 1 . Presentamos el caso de una paciente que tras visitar un restaurante de comida japonesa, elimina con la tos una forma juvenil de nemátodo. Caso ClínicoPaciente de 30 años, sexo femenino, sana, residente en la ciudad de Santiago. Asistió a un restaurante de comida japonesa, donde degustó sushi de variados sabores, algunos de ellos preparados con salmón crudo. Al día siguiente, comenzó con tos y estornudos, se

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Occupational conjunctivitis caused by sensitization to Anisakis simplex

Cited by 35 publications

References 4 publications

Anisakis simplex: from Obscure Infectious Worm to Inducer of Immune Hypersensitivity

Anisakis simplex: from Obscure Infectious Worm to Inducer of Immune Hypersensitivity

Anisakis pegreffii-Induced Airway Hyperresponsiveness Is Mediated by Gamma Interferon in the Absence of Interleukin-4 Receptor Alpha Responsiveness

Pseudoterranovosis y sushi

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