Occupational class and male cancer incidence: Nationwide, multicenter, hospital‐based case–control study in Japan

Zaitsu, Masayoshi; Kaneko, Rena; Takeuchi, Takumi; Sato, Yuzuru; Kobayashi, Yasuki; Kawachi, Ichiro

doi:10.1002/cam4.1945

Cited by 31 publications

(54 citation statements)

References 32 publications

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“…A nationwide, multicentered, hospital‐based, matched case‐control study was conducted with the Inpatient Clinico‐Occupational Database of Rosai Hospital Group (ICOD‐R), which is administered by the Japan Organization of Occupational Health and Safety. Details of the ICOD‐R have been described elsewhere . Briefly, the Rosai Hospital Group consists of 33 general hospitals throughout Japan.…”

Section: Methodsmentioning

confidence: 99%

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Light to moderate amount of lifetime alcohol consumption and risk of cancer in Japan

Zaitsu

Takeuchi

Kobayashi

et al. 2019

Cancer

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Background Even light to moderate alcohol consumption has been shown to increase cancer incidence. However, this association has not been well characterized in Japan. Methods Based on a nationwide, hospital‐based data set (2005‐2016), a multicenter case‐control study was conducted (63,232 cancer cases and 63,232 controls matched for sex, age, admission date, and admitting hospital). The total amount of lifetime alcohol consumption (drink‐years) was recalled for each patient by multiplication of the daily amount of standardized alcohol use (drinks per day) and the duration of drinking (years). Odds ratios (ORs) were estimated for overall and specific cancer sites via conditional logistic regression with restricted cubic splines, with adjustments made for smoking, occupational class, and comorbidities. Lifetime abstainers served as the reference group. Results Spline curves showed a dose‐response association with overall cancer risk: the minimum risk was at 0 drink‐years, and the OR at 10 drink‐years was 1.05 (95% confidence interval [CI], 1.04‐1.06). In comparison with lifetime abstainers, the OR for >0 to 20 drink‐years was 1.06 (95% CI, 1.01‐1.11). Those who drank 2 drinks or fewer per day had elevated odds for overall cancer risk across all duration‐of‐drinking categories. The same patterns were observed at light to moderate levels of drinking for most gastrointestinal/aerodigestive cancers as well as breast and prostate cancers. Analyses stratified by sex, different drinking/smoking behaviors, and occupational class mostly showed the same patterns for overall cancer incidence associated with light to moderate levels of drinking. Conclusions In Japan, even light to moderate alcohol consumption appears to be associated with elevated cancer risks.

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Section: Methodsmentioning

confidence: 99%

“…Each cancer case had a diagnosis with a specific cancer site (Table ). We defined cancer incidence as the first‐time admission among patients who did not have a previous history of cancer, and the validation for the diagnosis has been described elsewhere …”

Section: Methodsmentioning

confidence: 99%

Light to moderate amount of lifetime alcohol consumption and risk of cancer in Japan

Zaitsu

Takeuchi

Kobayashi

et al. 2019

Cancer

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“…Additionally, clinicopathological variables were included in survival analyses as potential mediating variables, ie, these variables do not confound the association between sex and RCC survival, but rather, they may help to explain the observed differences. Our clinicopathological variables of interest included the following: WHO pathological grade (grades 3 or 4 [high‐grade] vs grades 1 or 2 [low‐grade]), the Union for International Cancer Control TNM stage (stages III and IV [late stage] vs stages I and II [early stage]), and any performed surgeries including radical/partial nephrectomy (yes/no), as well as SES (high SES [with the longest‐held occupational class of managerial or professional workers] vs low SES) and smoking habits (never/ever).…”

Section: Methodsmentioning

confidence: 99%

“…Except for basic characteristics (age, sex, year of diagnosis, and survival time) and histological subtypes, records included missing data on mediating factors: pathological grade (1897, 36.0%), stage (1474, 28.0%), surgery (343, 6.5%), SES (4906, 93.2%), and smoking habits (3662, 69.6%). Excluding patients with missing data may lead to biased inference; therefore, we conducted multiple imputation for missing data among the 5265 study subjects with all variables used for analysis, and 20 imputed data sets were generated by the Multiple Imputation by Chained Equations method (Table ) …”

Section: Methodsmentioning

confidence: 99%

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Sex‐specific analysis of renal cell carcinoma histology and survival in Japan: A population‐based study 2004 to 2016

Zaitsu

Toyokawa

Takeuchi

et al. 2019

Health Science Reports

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Background and aims In Western countries, sex differences in renal cell carcinoma (RCC) histology and survival have been previously described: compared with men, clear cell subtype is more common but overall prognosis is better among women. The goal of the present study was to examine sex differences in RCC histology and survival in Japan, using a large‐scale population‐based data set. Methods With the use of a population‐based cancer registry in Japan (2004‐2016), patients with primary RCC were followed for 5 years (median follow‐up time 2.1 years). We distinguished histological subtypes of clear cell, papillary, and chromophobe from “others” subtype. Sex‐specific prevalence ratio (PR) for each histological subtype was estimated by Poisson regression with robust variance, adjusted for age and year of diagnosis. Sex‐specific survival rates were estimated by Cox proportional hazard regression, adjusted for age, year of diagnosis, histological subtypes, and other prognostic variables, with multiple imputation. Results The prevalence of clear cell and “others” subtypes was similar between men and women among all the 5265 study subjects during the 12 years of study (clear cell, male 88.6% vs female 87.1%; “others“, male 5.3% vs female 5.3%). However, papillary subtype was less common among women than men (male 4.6% vs female 2.8%; PR = 0.63; 95% CI, 0.45‐0.88), while chromophobe subtype was more common among women (male 1.6% vs female 4.8%; PR = 3.18; 95% CI, 2.26‐4.47). Although “others” subtype (but not papillary/chromophobe subtypes) independently predicted prognosis (HR = 1.74; 95% CI, 1.32‐2.30), no sex differences were observed in RCC survival. Conclusion We did not observe a statistically significant difference in the prevalence of clear cell subtype between men and women in Japan, which differs from the pattern previously described in Western countries. Sex differences in RCC histology may not affect RCC survival in this population.

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Mortality risks among blue- and white-collar workers: A time series study among Japanese men aged 25-64 years from 1980 to 2015

Dhungel

Murakami

Wada

et al. 2021

Journal of Occupational Health

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Objective We aimed to analyse age‐standardised mortality trends in Japan among blue‐ and white‐collar male workers aged 25‐64 years, by major causes of mortality from 1980 to 2015. Methods Five‐yearly mortality data were extracted from occupation‐specific vital statistics maintained by the Japanese Ministry of Health, Labour and Welfare. A time series study was conducted among employed men aged 25‐64 years. Age‐standardised mortality trends by occupational category were calculated separately for all cancers, ischaemic heart disease, cerebrovascular disease and suicide. Poisson regression analysis was performed to analyse mortality trends by occupational category for each cause. Results Mortality rates for all cancers and ischaemic heart disease were higher among white‐collar workers than blue‐collar workers throughout the 35‐year study period. The gap in the mortality rates for all four causes of death among blue‐ and white‐collar workers widened in 2000 after Japan's economic bubble burst in the late 1990s. Simultaneously, suicide mortality rates among white‐collar workers increased sharply and have remained higher than among blue‐collar workers. Conclusions White‐collar male workers in Japan have a higher risk of mortality than male blue‐collar workers. However, despite substantial differences, significant progress has been made in recent years in reducing mortality across all occupations in Japan.

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Occupational class and male cancer incidence: Nationwide, multicenter, hospital‐based case–control study in Japan

Cited by 31 publications

References 32 publications

Light to moderate amount of lifetime alcohol consumption and risk of cancer in Japan

Light to moderate amount of lifetime alcohol consumption and risk of cancer in Japan

Sex‐specific analysis of renal cell carcinoma histology and survival in Japan: A population‐based study 2004 to 2016

Mortality risks among blue- and white-collar workers: A time series study among Japanese men aged 25-64 years from 1980 to 2015

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