Occupational asthma due to chromium and nickel salts

Fernández‐Nieto, Mar; Quirce, Santiago; Carnés, Jerónimo; Sastre, Joaquı́n

doi:10.1007/s00420-005-0078-z

Cited by 50 publications

(25 citation statements)

References 15 publications

(29 reference statements)

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“…Indeed, inhaled particulate Cr(VI) is known to induce the production of several innate cytokines within airways (Beaver et al , 2009a; Beaver et al , 2009b). However, the presence of chromium-specific IgE reported in certain human occupational studies (Fernandez-Nieto et al , 2006; Novey et al , 1983) suggests that Cr(VI) may have the capacity to sensitize cells via antigen receptors, although it should be noted that the chromium exposure in these studies was over multiple years. At this point, neither mechanism can be ruled out without further studies.…”

Section: Discussionmentioning

confidence: 89%

“…Since then, numerous case studies (Bright et al , 1997; Fernandez-Nieto et al , 2006; Hannu et al , 2005; Leroyer et al , 1998; Moller et al , 1986; Novey et al , 1983; Olaguibel et al , 1989; Olaguibel and Basomba, 1989; Park et al , 1994), as well as larger studies (reviewed in Leikauf, 2002), suggest an association between occupational exposure to chromates and asthma. It should be noted that for most of these studies the type of asthma (allergic versus non-allergic) was not identified.…”

Section: Introductionmentioning

confidence: 99%

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Exposure to particulate hexavalent chromium exacerbates allergic asthma pathology

Schneider

Constant

Patierno

et al. 2012

Toxicology and Applied Pharmacology

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Airborne hexavalent chromate, Cr(VI), has been identified by the Environmental Protection Agency as a possible health threat in urban areas, due to the carcinogenic potential of some of its forms. Particulate chromates are produced in many different industrial settings, with high levels of aerosolized forms historically documented. Along with an increased risk of lung cancer, a high incidence of allergic asthma has been reported in workers exposed to certain inhaled particulate Cr(VI) compounds. However, a direct causal association between Cr(VI) and allergic asthma has not been established. We recently showed that inhaled particulate Cr(VI) induces an innate neutrophilic inflammatory response in BALB/c mice. In the current studies we investigated how the inflammation induced by inhaled particulate Cr(VI) might alter the pathology of an allergic asthmatic response. We used a well-established mouse model of allergic asthma. Groups of ovalbumin protein (OVA)-primed mice were challenged either with OVA alone, or with a combination of OVA and particulate zinc chromate, and various parameters associated with asthmatic responses were measured. Co-exposure to particulate Cr(VI) and OVA mediated a mixed form of asthma in which both eosinophils and neutrophils are present in airways, tissue pathology is markedly exacerbated, and airway hyperresponsiveness is significantly increased. Taken together these findings suggest that inhalation of particulate forms of Cr(VI) may augment the severity of ongoing allergic asthma, as well as alter its phenotype. Such findings may have implications for asthmatics in settings in which airborne particulate Cr(VI) compounds are present at high levels.

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Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Exposure to particulate hexavalent chromium exacerbates allergic asthma pathology

Schneider

Constant

Patierno

et al. 2012

Toxicology and Applied Pharmacology

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“…Exposure to cobalt-containing dust is frequently associated with skin sensitization (Walberg, 2000) and the development of occupational asthma (OA) (Bernstein and Merget, 2006). Chromium and nickel compounds are also skin sensitizers commonly associated with dermatitis (see for example, Halbert et al, 1992;Lide´n and Carter, 2001) and less commonly with OA (Bernstein and Merget, 2006;Ferna´ndez-Nieto et al, 2006). Skin exposure to tungsten also likely occurs, yet to our knowledge such exposures have not been associated with skin disorders.…”

Section: Introductionmentioning

confidence: 99%

Characterization of exposures among cemented tungsten carbide workers. Part II: Assessment of surface contamination and skin exposures to cobalt, chromium and nickel

Day

Virji

Stefaniak

2008

J Expo Sci Environ Epidemiol

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Cobalt, chromium and nickel are among the most commonly encountered contact allergens in the workplace, all used in the production of cemented tungsten carbides (CTC). Exposures to these metal-containing dusts are frequently associated with skin sensitization and/or development of occupational asthma. The objectives of this study were to assess the levels of cobalt, chromium and nickel on work surfaces and on workers' skin in three CTC production facilities. At least one worker in each of 26 work areas (among all facilities) provided hand and neck wipe samples. Wipe samples were also collected from work surfaces frequently contacted by the 41 participating workers. Results indicated that all surfaces in all work areas were contaminated with cobalt and nickel, with geometric means (GMs) ranging from 4.1 to 3057 mg/100 cm 2 and 1.1-185 mg/100 cm 2 , respectively; most surfaces were contaminated with chromium (GM ¼ 0.36-67 mg/100 cm 2 ). The highest GM levels of all metals were found on control panels, containers and hand tools, whereas lowest levels were on office and telecommunication equipment. The highest GM levels of cobalt and nickel on skin were observed among workers in the powder-handling facility (hands: 388 and 24 mg; necks: 55 and 6 mg, respectively). Levels of chromium on workers' skin were generally low among all facilities. Geometric standard deviations associated with surface and skin wipe measurements among work areas were highly variable. Exposure assessment indicated widespread contamination of multiple sensitizing metals in these three facilities, suggesting potential transfer of contaminants from surfaces to skin. Specific action, including improved housekeeping and training workers on appropriate use and care of personal protective equipment, should be implemented to reduce pathways of skin exposure. Epidemiologic studies of associated adverse health effects will likely require more biologically relevant exposure metrics to improve the ability to detect exposure-response relationships.

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“…Therefore, he may have been exposed to Ni occupationally, resulting in positive responses to both the patch and bronchial challenge tests with Ni. Moreover, the patient showed a late response to a specific bronchoprovocation test with Ni, a previously identified mechanism of Ni-induced OA (9). In some previous cases, however, specific IgE antibodies to Ni salts conjugated to human serum albumin were detected and showed an early asthmatic response in a specific inhalation test (9, 10).…”

Section: Discussionmentioning

confidence: 84%

Case Report of Occupational Asthma Induced by Polyvinyl Chloride and Nickel

et al. 2013

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Polyvinyl chloride (PVC) is a widely used chemical for production of plastics. However occupational asthma (OA) caused by PVC has been reported only rarely. We report a 34-yrold male wallpaper factory worker with OA due to PVC and nickel (Ni) whose job was mixing PVC with plasticizers. He visited the emergency room due to an asthma attack with moderate airflow obstruction and markedly increased sputum eosinophil numbers. A methacholine challenge test was positive (PC20 2.5 mg/mL). Bronchoprovocation tests with both PVC and Ni showed early and late asthmatic responses, respectively. Moreover, the fractional concentration of exhaled nitric oxide (FeNO) was increased after challenge with PVC. To our knowledge, this is the first case of OA in Korea induced by exposure to both PVC and Ni. We suggest that eosinophilic inflammation may be involved in the pathogenesis of PVC-induced OA and that FeNO monitoring can be used for its diagnosis.

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Occupational asthma due to chromium and nickel salts

Abstract: Chromium and nickel salts can give rise to occupational asthma in exposed workers. The underlying mechanism may be IgE-mediated in some cases.

Cited by 50 publications

References 15 publications

Exposure to particulate hexavalent chromium exacerbates allergic asthma pathology

Exposure to particulate hexavalent chromium exacerbates allergic asthma pathology

Characterization of exposures among cemented tungsten carbide workers. Part II: Assessment of surface contamination and skin exposures to cobalt, chromium and nickel

Case Report of Occupational Asthma Induced by Polyvinyl Chloride and Nickel

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