“…Aminophylline results from the linkage of ethylenediamine to theophylline; it has been responsible for numerous cases of allergic contact dermatitis [Baer et al, 1959] but also for cases of allergic reactions after systemic administration: eczema [Walker and Ferguson, 2004], urticaria [Urbani, 1994], exfoliative erythroderma [Elias and Levinson, 1981], and baboon syndrome [Guin et al, 1999]. Numerous cases of occupational asthma to ethylenediamine have also been reported since 1963 [Gelfand, 1963; Lam and Chan‐Yeung, 1980; Aldrich et al, 1987] and some of them have been documented by specific bronchial provocation tests [Nakazawa and Matsui, 1990; Ng et al, 1991, 1995; Casas et al, 2002; Villar‐Gomez et al, 2009]. Cross‐reactions between EDTA and ethylenediamine in skin tests have been reported [Raymond and Gross, 1969; Eriksen, 1975], but appear to be rare [Provost and Jillson, 1967; Epstein, 1974; Fisher, 1975; Balato et al, 1986; de Groot, 1986; Bhushan and Beck, 1998; Pruitt and Warshaw, 2010].…”