Is the incidence of aliphatic amine‐induced occupational rhinitis and asthma underestimated?

Abstract

The frequency of amine-induced OR/OA may be underestimated, particularly when cleaning products are incriminated. Comprehensive investigation of all cases is mandatory to ensure an efficient prevention policy and consequently a good clinical and socio-occupational prognosis of occupational respiratory disease.

Allergic contact dermatitis in two employees of an ethylene amine‐producing factory

“…An assay for specific IgE for EDA has not been developed yet, and could therefore not be utilized. Occupational rhinitis caused by ethylene amines has been described previously, although the exact mechanism remains unclear . Case 2 presented with hand eczema, with positive patch test reactions to the same substances as case 1.…”

Occupational rhinitis and occupational asthma: Association or progression?

“…Notwithstanding this limitation, 6 of the 43 studies lacking cross‐tabulation (plus all four studies lacking objective pulmonary function tests) provided partial associational data, in which either: 1) the proportion of (presumed) occupational rhinitis cases developing occupational asthma (or vice versa) is reported (albeit in the absence of background rates); or 2) the sequence of development of nasal and chest symptoms are tabulated. Individual study characteristics of excluded studies, including study designs, principal exposure(s), health endpoint(s), number of subjects, and measure(s) of effect appear in Supplemental Tables S1‐S4. Briefly summarizing relevant data from these excluded studies, among workers undergoing objective pulmonary function testing, more than half of those diagnosed with occupational asthma to diphenylmethane diisocyanate (MDI), lupin ( Lupinus angustifolius ) flour, or ammonium persulfate (eg, hairdressers) also gave histories consistent with occupational rhinitis .…”

Machine learning–driven identification of early-life air toxic combinations associated with childhood asthma outcomes

“…Triethylamine is a clear, colorless liquid used in waterproofing and as a catalyst, corrosion inhibitor, and propellant (45). It is a respiratory irritant, to which chronic exposure even at low levels can inhibit the function of organic cationic transporters, thus preventing efficient uptake of inhaled bronchodilators used to control acute asthma symptoms (46,47).…”