Occupational allergic contact dermatitis from tetrahydrofurfuryl acrylate in a medical‐device adhesive

Moffitt, D. L.; Sansom, Jane

doi:10.1034/j.1600-0536.2001.045001054.x

Cited by 12 publications

(8 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…One of the patients showed simultaneous positive reactions to IBOA, DMAA, and THF‐A 0.1% pet. Two occupational cases of contact allergy to THF‐A found in a medical device adhesive used at a factory assembling surgical needles have previously been described 13 . One of these patients showed a simultaneous positive reaction to DMAA (1% pet.)…”

Section: Discussionmentioning

confidence: 98%

“…The SLM constituents alantolactone, costunolide, and dehydrocostus lactone were tested at 0.1% wt/vol in ethanol. Patch testing also included substances indicated to be present in glucose sensors and insulin pumps according to GC‐MS analyses at our department and substances believed to occur in ultraviolet‐cured adhesives used in medical devices according to safety data sheets or previous publications 11‐13 …”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Contact dermatitis caused by glucose sensors—15 adult patients tested with a medical device patch test series

et al. 2020

View full text Add to dashboard Cite

Background Several cases of allergic contact dermatitis (ACD) to the glucose sensor FreeStyle Libre have been reported. Isobornyl acrylate (IBOA) and N,N‐dimethylacrylamide (DMAA) are known culprit allergens. Objectives To evaluate patients with suspected ACD to FreeStyle Libre in a standardized manner, present causative allergens, and assess patient‐reported implications. Methods A total of 15 patients with suspected ACD to FreeStyle Libre were patch tested with the Swedish baseline series and a new medical device series. IBOA and DMAA were tested at 0.1% and 0.3% in petrolatum (pet.). Readings were performed on day (D) 3 and D7. Background data, details on skin reactions, and associated implications were assessed using a questionnaire. Results Thirteen patients were sensitized to IBOA and four to DMAA. Two positive reactions to IBOA and one to DMAA were seen only at 0.3% concentration on D7. Median duration of sensor use before dermatitis onset was 6 months. Half the number of the patients took precautions in everyday life due to sensor‐related skin reactions. Six patients discontinued sensor usage. Conclusions Patients with suspected ACD to glucose sensors should be evaluated with a relevant patch test series containing IBOA and DMAA. Adding the 0.3% pet. concentration is recommended. The reading on D7 is necessary.

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Methodsmentioning

confidence: 99%

Contact dermatitis caused by glucose sensors—15 adult patients tested with a medical device patch test series

et al. 2020

View full text Add to dashboard Cite

show abstract

“…When patch testing was performed, positive reactions to DMAA and tetrahydrofurfuryl acrylate, which were both ingredients of the adhesive, were observed. 13 Contact allergy to acrylamide, N,N 0 -methylenebisacrylamide and N-methylolacrylamide has been reported in printers handling photopolymerizing printing plates. 14 Contact allergy to acrylamide has also been described in a "batch-mixer" employed at a plastics factory.…”

Section: Discussionmentioning

confidence: 99%

“…This case was a worker at a factory assembling surgical needles who reacted to a medical device adhesive used at the factory. When patch testing was performed, positive reactions to DMAA and tetrahydrofurfuryl acrylate, which were both ingredients of the adhesive, were observed …”

Section: Discussionmentioning

confidence: 99%

N,N‐dimethylacrylamide—A new sensitizer in the FreeStyle Libre glucose sensor

et al. 2019

View full text Add to dashboard Cite

Background Isobornyl acrylate (IBOA) has recently been identified as one sensitizer in the FreeStyle Libre glucose sensor. Analyses with gas chromatography‐mass spectrometry (GC‐MS) have indicated the presence of N,N‐dimethylacrylamide (DMAA) in the sensor. Material and methods Seven patients were referred for patch testing after developing skin reactions when using FreeStyle Libre. All patients were patch tested with IBOA and DMAA. Two patients were tested with adhesive patches that had been removed from the sensors “as is,” and two patients were tested with acetone extracts of materials from the sensor. The extracts were analysed with GC‐MS. Results Six patients reacted to both IBOA and DMAA, and one patient reacted only to DMAA. Positive reactions were also observed in both patients tested with the adhesive patch "as is". One patient reacted to both an extract of the adhesive patch and an extract of the sensor itself. When analysed with GC‐MS, IBOA was found in both extracts and DMAA was found in the extract of the sensor. Conclusion Both IBOA and DMAA may be present in adhesives used in medical devices such as glucose sensors or insulin pumps, and should be patch tested when suspected contact allergic reactions to these products are investigated.

show abstract

“…Tetrahydrofurfuryl acrylate (THFA) and tetrahydrofurfuryl methacrylate (THFMA) are components of acrylic adhesives. Although a positive reaction to THFMA has been considered a cross‐reaction to other acrylic resins, Moffitt et al reported patients who were sensitized by THFA. Here, we report on nonoccupational allergic contact dermatitis due to THFA from the clip‐on earring adhesive resin.…”

mentioning

confidence: 99%

Allergic contact dermatitis caused by tetrahydrofurfuryl acrylate in the adhesive of clip‐on earrings

et al. 2019

View full text Add to dashboard Cite

Occupational allergic contact dermatitis from tetrahydrofurfuryl acrylate in a medical‐device adhesive

Cited by 12 publications

References 2 publications

Contact dermatitis caused by glucose sensors—15 adult patients tested with a medical device patch test series

Contact dermatitis caused by glucose sensors—15 adult patients tested with a medical device patch test series

N,N‐dimethylacrylamide—A new sensitizer in the FreeStyle Libre glucose sensor

Allergic contact dermatitis caused by tetrahydrofurfuryl acrylate in the adhesive of clip‐on earrings

Contact Info

Product

Resources

About