Occupation and the risk of lung cancer in Uruguay

Stéfani, Eduardo De; Kogevinas, Manolis; Boffetta, Paolo; Ronco, Álvaro L.; Mendilaharsu, Marı́a

doi:10.5271/sjweh.152

Cited by 55 publications

(27 citation statements)

References 9 publications

(11 reference statements)

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“…In 14 other studies, employment duration as a welder was used as a quantitative exposure estimate, but the time periods used differed between the studies. In six papers, the results for the welders with >20 years of exposure were available (18,24,26,33,37,66). Four of them showed an SMR above one, but none of them reached significance.…”

Section: Discussionmentioning

confidence: 99%

Update of a meta-analysis on lung cancer and welding

Ambroise¹,

Wild²,

Moulin³

2006

Scand J Work Environ Health

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Section: Discussionmentioning

confidence: 99%

Update of a meta-analysis on lung cancer and welding

Ambroise¹,

Wild²,

Moulin³

2006

Scand J Work Environ Health

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“…As a result, we chose 30 studies in 25 papers which stated a relationship between silica exposure and lung cancer risk: 17 cohort studies in 17 papers [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] (Table 1) and 13 case-control studies in 8 papers 13,[19][20][21][22][23][24][25] (Table 2). We also chose 16 studies (11 cohort 4,9,11,15,[26][27][28][29][30][31][32] and 5 case-control studies 19,[33][34][35][36] ) which stated a relationship between silicosis and lung cancer risk (Tables 3 and 4).…”

Section: Lung Cancer Risks From Silica Exposure Silicosis and Nonsilmentioning

confidence: 99%

Silicosis and Smoking Strongly Increase Lung Cancer Risk in Silica-Exposed Workers

Kurihara

Wada

2004

INDUSTRIAL HEALTH

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It remains controversial whether silica is a human lung carcinogen. In this study, we estimated the relative risks of lung cancer due to silica and silicosis by meta-analysis. We collected papers published from 1966-2001 which epidemiologically reported on the relationship between silica/silicosis and lung cancer. We removed papers which did not exclude the effects of asbestos and radioactive materials including radon. We selected the most recent one if some papers were based on the same cohort. Based on the selected papers, we summarized the lung cancer risks from silica, silicosis and non-silicosis with exposure to silica, by meta-analysis using a random effects model. The pooled relative risks were 1.32 (95% confidence interval (CI), 1.23-1.41) for silica, 2.37 (95% CI, 1.98-2.84) for silicosis and 0.96 (95% CI, 0.81-1.15) for non-silicosis with exposure to silica. Since some papers on silica did not exclude silicosis, the risk due to silica itself may be smaller than 1.32. It was less possible that silica exposure directly increases lung cancer risk. On the other hand, the relative risk, 2.37 for silicosis suggested that silicosis increases lung cancer risk. Meta-analysis also revealed that cigarette smoking strongly increased the lung cancer risk in silicotic patients (relative risk, 4.47; 95% CI, 3.17-6.30). Thus, the present study suggested the great importance of preventing silicosis and smoking cessation in reducing lung cancer incidence in silica-exposed workers.

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“…Several epidemiologic studies have shown that PTS including PAHs and OCPs can be absorbed by human body through the skin, lungs, and alimentary canals, and can induce skin cancer, lung cancer, stomach cancer, breast cancer, uterine myoma, prostate cancer, and scrotum cancer (Jane et al, 2000). Occupational exposure to DDT is associated with increased lung cancer in a case control study of Uruguayan work force (Destefani et al, 1996). According to the International Agency for Research on Cancer (IARC,1987), soot and tar, untreated and mildly treated mineral oils, and processes used in the production of aluminum and coke or in iron and steel foundries are carcinogenic in humans.…”

Section: Introductionmentioning

confidence: 99%

Environmental pollution by persistent toxic substances and health risk in an industrial area of China

Lü

Shi

et al. 2011

Journal of Environmental Sciences

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Soil is an important environmental medium that is closely associated with humans and their health. Despite this, very few studies have measured toxicants in soils, and associated them with health risks in humans. An assessment of health effects from exposure to contaminants in soils surrounding industrial areas of chemical production and storage is important. This article aims at determining pollution characteristics of persistent toxic substances (PTS) in an industrial area in China to unravel the relationship between soil pollution by PTS and human health. One hundred and five soil samples were collected and 742 questionnaires were handed out to residents living in and around an industrial area around Bohai Bay, Tianjin in Northern China. Concentrations of organochlorine pesticides and polycyclic aromatic hydrocarbons (PAHs) were determined in soil. Mann-Whitney U and binary multivariate nonconditional logistic regression models were employed to analyze the relationship between health indicators of local residents and contaminant levels. Odds ratio (OR) and a 95% confidence interval (CI) for health incidences were also calculated. The average concentrations of DDT (73.9 ng/g), HCH (654 ng/g) and PAHs (1225 ng/g) were relatively high in the industrial area. Residents living in the chemical industry parks were exposed to a higher levels of PTS than those living outside the chemical industry parks. This exposure was associated with a higher risk of breast cancer (OR 1.87, 95% CI 0.12-30.06), stomach cancer (OR 1.87, 95% CI 0.26-13.41), dermatitis (OR 1.72, 95% CI 1.05-2.80), gastroenteritis (OR 1.59, 95% CI 0.94-2.68), and pneumonia (OR 1.05, 95% CI 0.58-1.89).

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Occupation and the risk of lung cancer in Uruguay

Cited by 55 publications

References 9 publications

Update of a meta-analysis on lung cancer and welding

Update of a meta-analysis on lung cancer and welding

Silicosis and Smoking Strongly Increase Lung Cancer Risk in Silica-Exposed Workers

Environmental pollution by persistent toxic substances and health risk in an industrial area of China

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