Nuclear receptors (NRs) regulate transcription in a ligand-dependent way through two types of coactivator complexes: the p160/CBP histone acetyl transferase (HAT) complex and the DRIP/TRAP/SMCC complex without HAT activity. Here we identified a large human (h) coactivator complex necessary for the estrogen receptor alpha (ERalpha) transactivation. This complex contains the GCN5 HAT, the c-Myc interacting protein TRRAP/PAF400, TAF(II)30, and other subunits. Similarly to known TFTC (TBP-free TAF(II)-containing)-type HAT complexes (hTFTC, hPCAF, and hSTAGA), TRRP directly interacted with liganded ER alpha, or other NRs. ER alpha transactivation was enhanced by the purified complex in vitro. Antisense TRRAP RNA inhibited estrogen-dependent cell growth of breast cancer cells. Thus, the isolated TFTC-type HAT complex acts as a third class of coactivator complex for NR function.

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The ultrafast intersubband relaxation in GaN quantum wells has been verified. Al0.65Ga0.35N/GaN multiple quantum wells, with as many as 200 wells, were grown by optimizing the barrier thickness and introducing GaN intermediate layers. The intersubband absorption is sufficiently strong for the relaxation time to be measured. A pump–probe measurement is performed to investigate the relaxation. An ultrashort relaxation time of less than 150 fs is obtained at a wavelength of 4.5 μm. The transient time is shorter than that of InGaAs quantum wells by approximately an order of magnitude. This result is promising for realizing ultrafast optical switches.

We studied the optical and magnetic properties in epitaxial AlN/GdN/AlN double heterostructures grown using reactive sputtering under ultrapure conditions. The indirect and direct optical transitions in a 95-nm-thick GdN film were found to be 0.95 and 1.18 eV, respectively. The considerable size effects of the optical band gap were observed with a decrease in the GdN thickness. The AlN/GdN/AlN double heterostructures clearly exhibited ferromagnetic states at low temperature. The short-range correlation of spins began to develop below ∼60 K, and long-range ordering that obeyed the Arrott relation was confirmed below ∼30 K. Because of the film-size independence for the ferromagnetic ordering, the cooperative correlation length in GdN was considered to be shorter than 30 nm. Furthermore, we found that the band gap is dramatically reduced with the ferromagnetic spin ordering.

A carcinogenic heterocyclic amine, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), was measured in condensate of cigarette mainstream smoke by HPLC. PhIP was detected in all brands of filter-tipped cigarettes analyzed. The mean level of PhIP in the cigarette mainstream smoke was 16.4 ng/cig.