Occupation and smoking as risk factors for lung cancer: A population‐based case‐control study

Ruano-Raviña, Alberto; Figueiras, Adolfo; Barreiro‐Carracedo, María Amparo; Barros-Dios, Juan Miguel

doi:10.1002/ajim.10171

Cited by 21 publications

(7 citation statements)

References 44 publications

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“…MG computed from both markers was used as a decision parameter. Results shown in table 1 suggest that the population with suspicious automated sputum cytology results were characterised by higher inhalation of tobacco, simultaneously occupational exposure to harmful agents and more complaints of a chronic cough; all of which are in accordance with the results of epidemiological studies assessing risk factors in lung cancer [16,24]. This may well indicate that those individuals with positive cytometric results may be considered as a particularly high-risk population for the development of lung cancer in heavy smokers.…”

Section: Discussionsupporting

confidence: 72%

Predictive value of image cytometry for diagnosis of lung cancer in heavy smokers

Xing¹

2005

European Respiratory Journal

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The Research Institute for Diagnosis and Treatment of Early Lung Cancer (RIDTELC) Lung Study was initiated to determine whether lung cancer screening by automated sputum cytometry combined with conventional sputum cytology and auto-fluorescence in addition to white light bronchoscopy could enhance the detection rate of early lung cancer. The present study analyses the initial findings to evaluate the efficiency of automated sputum cytology in predicting the diagnosis of lung cancer.In this study, malignancy grade was used as a predictive parameter for lung cancer. In total, 2,480 heavy smokers (.30 pack-yrs), aged 50-74 yrs, with no previous cancer in the last 5 yrs, received chest radiology, conventional sputum cytology and sputum cytometry screening.In total, twenty-seven lung cancers were diagnosed, representing a prevalence of 1.1%, 25 of which provided sputum samples. Positive automated sputum cytology results were seen in 176 smokers (7.2%), 10 (0.4%) of whom had severe dysplasia or higher lesions (positive results) by conventional sputum cytology examination. Out of 25 tumour cases, 20 had suspicious results using automated sputum cytology, representing 80% sensitivity. One patient out of 24 with tumours had positive results on conventional sputum cytology, representing a sensitivity of 4.2%. For all stages of squamous cell lung cancer and later stage adenocarcinoma the sensitivity of automated sputum cytology was 100%. For adenocarcinoma stage I sensitivity was 25%.In conclusion, DNA analysis of sputum slides by automated sputum cytology may be a suitable tool for the detection of early lung cancer and the characterisation of a high-risk group with preinvasive lesions for follow-up.

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Section: Discussionsupporting

confidence: 72%

Predictive value of image cytometry for diagnosis of lung cancer in heavy smokers

Xing¹

2005

European Respiratory Journal

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“…50 The influence of occupation and lung cancer mortality risk varies considerably as a function of the duration and intensity of carcinogen exposure. 51,52 Occupational exposure assessment using detailed interviews enables the construction of a job-exposure matrix. This approach generally leads to stronger associations between highrisk occupations and lung cancer risk than when job title is used as a surrogate for job exposure as was the case in the present study.…”

Section: Discussionmentioning

confidence: 99%

Occupation and Lung Cancer Mortality in a Nationally Representative U.S. Cohort: The National Health Interview Survey (NHIS)

Lee

Fleming

LeBlanc

et al. 2006

Journal of Occupational and Environmental Medicine

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“…Each subject was also classified according to whether or not he or she had worked in occupations at risk for lung cancer following the classification proposed by Ahrens and Merletti 15 which has been used elsewhere. 16 Subjects were considered to have been occupationally exposed if they had worked for more than 1 year in one of the occupations at risk for lung cancer.…”

Section: Design Subjects and Settingsmentioning

confidence: 99%

Type of wine and risk of lung cancer: a case-control study in Spain

Ruano-Raviña

Figueiras²,

Dios³

2004

Thorax

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Background: Few epidemiological studies have examined the effect of wine on the risk of lung cancer. A study was therefore undertaken to estimate the effect of wine consumption, both overall and by type of wine, on the risk of developing lung cancer. Methods: A hospital based case-control study was conducted on 319 subjects (132 cases, 187 controls) in 1999-2000. All subjects were interviewed about their lifestyles with particular reference to alcohol consumption and tobacco use. The results were analysed using non-parametric logistic regression. The main outcome measure was the risk of lung cancer associated with consumption of wine and its individual types. Results: A very slight but significant association was observed between the risk of lung cancer and white wine consumption (odds ratio (OR) 1.20 for each daily glass). Red wine consumption, on the other hand, had an OR of 0.43 (95% CI 0.19 to 0.96), with each daily glass of red wine having an inverse association with the development of lung cancer (OR 0.87 (95% CI 0.77 to 0.99)). There was no apparent association between lung cancer and consumption of beer or spirits. Conclusions: These results suggest that the consumption of red wine is negatively associated with the development of lung cancer. Further studies are needed to test this finding in cancer induced laboratory animals.

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Occupation and smoking as risk factors for lung cancer: A population‐based case‐control study

Abstract: The high risks observed indicate a public health problem and indicate that joint exposure to risk professions and tobacco ought to be avoided. We must stress from these results the need for effective education for all workers.

Cited by 21 publications

References 44 publications

Predictive value of image cytometry for diagnosis of lung cancer in heavy smokers

Predictive value of image cytometry for diagnosis of lung cancer in heavy smokers

Occupation and Lung Cancer Mortality in a Nationally Representative U.S. Cohort: The National Health Interview Survey (NHIS)

Type of wine and risk of lung cancer: a case-control study in Spain

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