Occupation and gastric cancer in Spain.

González, Carlos; Sanz, Miguel León; Marcos, Guillermo; Pita, Salvador; Brullet, Enric; Vida, Francesc; Agudo, Antonio; Hsieh, Chung-Cheng

doi:10.5271/sjweh.1707

Cited by 42 publications

(24 citation statements)

References 22 publications

(27 reference statements)

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“…49 Similarly, employment in construction has been inconsistently associated with gastric cancer, 50 our result is in agreement with findings of several other studies which did not find an association. [51][52][53][54][55] Some occupations including work in mining, transport, basic metal manufacturing and paper products and printing that have previously reported to link to GC do not exist in Ardabil province or the numbers are too small to be evaluated.…”

Section: Discussionmentioning

confidence: 99%

The role of diet and other environmental factors in the causation of gastric cancer in Iran—A population based study

Pourfarzi

Whelan

Kaldor

et al. 2009

Intl Journal of Cancer

126

107

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Despite a declining trend in the incidence of gastric cancer (GC), it is still a major global public health concern of the 21st century. The rates of GC reported from Ardabil Province, Iran, are among the highest in the world. To investigate risk factors for GC in Ardabil, we undertook a population-based case-control study. The study aimed to recruit all Ardabil residents newly diagnosed with GC in the time period of 2004-2005, and 2 controls per case. Participants were interviewed using a structured questionnaire. Ten milliliters of blood was collected for blood grouping and investigating the presence of IgG antibodies against Helicobacter pylori. During the study period, 217 people with GC and 394 controls were recruited. In multivariate analysis, diet and Helicobacter pylori infection (OR 5 2.41; 95% CI: 1.35-4.32) were found to be the factors that were most strongly related to GC. High intake of Allium vegetables (OR 5 0.35) and fruit, especially citrus fruit (OR 5 0.31) and consumption of fresh fish (OR 5 0.37) were significantly protective. On the other hand, consumption of red meat (OR 5 3.40) and dairy products (OR 5 2.28) were positively associated with the risk of GC. People who had a preference for higher salt intake (OR 5 3.10) and drinking strong and hot tea (OR 5 2.64 and 2.85, respectively) were at higher risk. In conclusion, Helicobacter pylori infection as measured by serum IgG as well as the consumption of red meat and dairy products increases the risk of GC in Ardabil, while the intake of fresh fruit and fresh fish decrease the risk. ' 2009 UICC

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Section: Discussionmentioning

confidence: 99%

The role of diet and other environmental factors in the causation of gastric cancer in Iran—A population based study

Pourfarzi

Whelan

Kaldor

et al. 2009

Intl Journal of Cancer

126

107

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“…Mirvish 5 and IARC 33 recognized the association of GC with exposure to mineral dust and to coal. In a case-control study carried out by Gonzales et al 7 in 1991, the GC association was elevated by work in mines after about 20 years of exposure. However, we did not find a significant difference between the industrialized and non-industrialized area of Baixada Santista.…”

Section: Discussionmentioning

confidence: 95%

“…The better preservation of foodstuffs as a consequence of refrigeration, especially for meat, fruit, and vegetables, has resulted in the reduction of nitrites and salt content and an increase in the C, E, and A vitamin consumption and in the reduction of contamination risks 4,5,7,27,28 .…”

Section: Discussionmentioning

confidence: 99%

“…Although the excessive mortality of GC and CRC has usually been associated with lifestyle in urban and industrialized areas, several authors have shown a relationship between these kinds of cancer and exposure to occupational carcinogenic agents [4][5][6][7][8] . Baixada Santista is an important port and industrial center in the state of São Paulo (SP), Brazil, where industrial wastes with carcinogenic substances have been found 9,10 , and it has the highest general mortality by cancer in SP 3 .…”

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Gastric and colorectal cancer mortality in an urban and industrialized area of Brazil

2001

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Purpose: To study the gastric and colorectal cancer mortalities and their relation to the urban-industrialization in Baixada Santista, located in the southeastern region of Brazil.Methods: Selected from the registries of the State System of Data Analysis Foundation (SEADE) were 1105 deaths due to gastric cancer and 690 due to colorectal cancer (ICD 151) that occurred from 1980 to 1993 in males, above 10 years of age, residing in Baixada Santista. For each of these types of cancer, the standardized mortality rates, age-adjusted by world population in the 1960s, for 4 industrialized and 4 non-industrialized urban communities in that region were calculated. The ratios among those rates were calculated in order to compare the mortality in the periods 1980-93, 1980-1986, and 1987-1993.Results: Standardized mortality rates for colorectal cancer were significantly higher in industrialized area, with ratios of 1.6 [95% CI 1.22 -2.29], 1.6 [95% CI 1.2 -2.0], and 1.6 [95% CI 1.3 -2.0] in the periods 1980-86, 1987-1993 and 1980-93, respectively. Gastric cancer did not show any statistical difference between the industrialized and non-industrialized areas, but there was a significant decrease in BS from the period 1980-1986 to 1987-1993.Conclusions: The significant elevation of colorectal cancer mortality in the industrialized area could be related to exposure to numerous carcinogens such as aromatic hydrocarbon, organic-chloride, metals, and industrial-port dust present in the region. Alternatively, the non-significant difference in gastric cancer between industrialized and non-industrialized areas and significant decrease in the last few years could be predominately reflecting the advances in the quality of life in urban areas. These results require further case-control studies that could help with the analysis of the associations among cancer and environmental factors (occupational, urban-industrial, habit, and life condition) and genetic susceptibility. Parkin in 1993 1 , analyzing estimates for the world incidence of cancer for males up to the year 1985, observed that gastric cancer (GC) was in second place (25.4/100,000) and colorectal cancer (CRC) in third place (17.8/100,000). When the incidences among developed and developing countries were considered, he observed GC in first place in the former, including the tropical region of South America in which Brazil is situated, while CRC ranked second in all developed countries.In Brazil, the morbidity and mortality due to GC has risen, reaching first place among all kinds of cancer in the 1970s and 1980s, except in the more developed regions such as the south and southeast. In contrast, the mortality and incidence of CRC are not as high, and this type of cancer is not ranked among the first five 2,3 .Although the excessive mortality of GC and CRC has usually been associated with lifestyle in urban and industrialized areas, several authors have shown a relationship between these kinds of cancer and exposure to occupational carcinogenic agents 4-8 .

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“…In a second larger, multicenter case-control study (13) The association between occupational exposure and stomach cancer in Spain was investigated in a multicenter case-control study conducted in areas of Catalonia, Aragon, Castilia, and Galicia (25). An increased risk (adjusted for socioprofessional status and dietary habits) was found for coal mining workers (OR = 11.8), but the number of exposed workers was small (95% CL= 1.4-103).…”

Section: Case-control Studiesmentioning

confidence: 99%

Occupational Cancer in Spain

González¹,

Agudo²

1999

Environmental Health Perspectives

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The knowledge of specific problems of occupational cancer in Spain is scarce. The environment of the workplace has improved over the last few years after a long period distinguished by bad working conditions, incomplete legislation, and insufficient safety measures and control. It has been estimated that 3,083,479 workers (25.4% of employees) were exposed to carcinogens. The most common occupational exposures to carcinogenic agents were solar radiation, environmental tobacco smoke, silica, and wood dust. The highest number of employees were exposed to silica crystalline (404,729), diesel engine exhaust (274,321), rubber products (99,804), benzene (89,932), ethylene dibromide (81,336), agents used in furniture and cabinet making (72,068), and formaldehyde (71,189). The percentage of total cancer deaths attributed to occupational exposure was 4% (6% in men, 0.9% in women). Compared with other European countries, the incidence of lung cancer and leukemia in Spain are one of the lowest, but it is rapidly increasing. The incidence of urinary bladder and larynx cancer, on the contrary, are one of the highest. Few studies on occupational cancer have been conducted in Spain. The main problems are the availability of death certificates and the quality of the information on occupation in mortality of statistics. It is necessary to improve methods of assessment of exposures using expert hygienists and biologic markers of exposure and diseases. Reduction of cancer by limiting or avoiding exposure to known occupational carcinogens is still necessary. -

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Occupation and gastric cancer in Spain.

Cited by 42 publications

References 22 publications

The role of diet and other environmental factors in the causation of gastric cancer in Iran—A population based study

The role of diet and other environmental factors in the causation of gastric cancer in Iran—A population based study

Gastric and colorectal cancer mortality in an urban and industrialized area of Brazil

Occupational Cancer in Spain

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