Occult Osteomalacia Amongst Healthy and Pregnant Women in Pakistan

Rab, S. M.; Baseer, Abdul

doi:10.1016/s0140-6736(76)91141-7

Cited by 48 publications

(23 citation statements)

References 6 publications

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“…Sachan et al [23] reported that although none of the women had clinical manifestations suggesting osteomalacia, 14% of them had elevated heat-stable alkaline phosphatase (HALP). Rab and Baseer [24] reported in the population with low vitamin D intake (88±14 IU/d) in the population, and the incidence of elevated total AP was 26%. Brook et al [15] found that 20% of their subjects with serum 25(OH)D<25 nmol/L had elevated HALP.…”

Section: Brief Reportmentioning

confidence: 88%

High prevalence of vitamin D and calcium deficiency among pregnant women and their newborns in Chengdu, China

et al. 2010

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Section: Brief Reportmentioning

confidence: 88%

High prevalence of vitamin D and calcium deficiency among pregnant women and their newborns in Chengdu, China

et al. 2010

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“…But pardah-observing Muslim women of Pakistan (18), Asian immigrants in the UK (10), Malaysians (21) and even Caucasians (2,23) have shown significantly lower serum calcium phosphate and elevated HLAP in pregnancy. 81 % of Asian immigrant mothers are reported to have 25-(OH) D levels in the osteomalacic range (9).…”

Section: Introductionmentioning

confidence: 98%

Effects of Vitamin D Supplementation in Pregnancy

Marya¹,

Rathee²,

Lata³

et al. 1981

Gynecol Obstet Invest

134

100

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Serum calcium, inorganic phosphate and heat-labile alkaline phosphatase (HLAP) have been estimated in maternal and cord sera of 120 pregnant women at labour. 75 women who did not take any vitamin D supplements during pregnancy showed statistically significant hypocalcaemia, hypophosphataemia and elevation of HLAP. Hypocalcaemia and hypophosphataemia were present in cord blood, too. 25 women who had received 1,200 U vitamin D/day throughout the 3rd trimester, showed significantly lower HLAP levels and increased fetal birth weight but there was no other improvement in maternal or cord blood chemistry. Administration of vitamin D in two large doses of 600,000 U each in the 7th and 8th months of pregnancy in 20 women proved more efficacious. Statistically significant improvement was observed in all the three biochemical parameters in maternal as well as cord sera. Fetal birth weight was also significantly greater with this mode of therapy.

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“…High incidences of osteoporotic fractures have been reported in Indian women above 40 y of age (Shatrugana et al, 1990). Vitamin D deficiency was reported in varying degrees in tropical an subtropical countries among children and women (Rab, 1976;Bhattacharyya, 1992;Atiq et al, 1998). In some areas of Bangladesh, a high prevalence of nutritional rickets was reported in children (Ministry of Health and Family Welfare, 1995).…”

Section: Introductionmentioning

confidence: 99%

Vitamin D deficiency: a concern in premenopausal Bangladeshi women of two socio-economic groups in rural and urban region

et al. 2002

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Objective: The study was designed to evaluate the vitamin D status in women of different physiological status of two socioeconomic groups in Bangladesh. Design: A cross-sectional study, using serum 25-hydroxyvitamin D (25-OHD), calcium, phosphorus and alkaline phosphatase activity. Setting: Two regions of Bangladesh. The Dhaka city area and west region of Nandail (Betagair Union), Mymensingh. Subjects: Representative subjects of two groups (low socio-economic group ¼ group L, n ¼ 99; and high socio-economic group ¼ group H, n ¼ 90) of Bangladeshi women aged 16 -40 y. About 87% of the subjects were housewives and the rest, 13%, were distributed among other different professions. Each group comprised of three sub-groups (non-pregnant nonlactating ¼ 1, pregnant ¼ 2, and lactating ¼ 3). Results: The influence of socio-economic status and physiological status on serum 25-OHD concentration (P ¼ 0.038, P ¼ 0.015, respectively), serum calcium concentration (P < 0.001, P < 0.001, respectively) and alkaline phosphatase activity (P < 0.001, P < 0.001, respectively) were observed. The distribution of serum 25-OHD concentration in both groups was shifted overall toward the lower limit of the normal range. Seventeen percent of women in group L and 12% of women in group H had serum 25-OHD concentration < 25 nmol=l. Hypovitaminosis D (serum 25-OHD concentration 37.5 nmol=l) was observed in 50% of subjects in group L and 38% of subjects in group H, respectively. The prevalence of hypovitaminosis was higher in lactating subjects of the groups L and H (63 and 46%, respectively) than in the other sub-groups in the same group. Conclusions: The results of the study suggested that women in Bangladesh were at risk of hypovitaminosis D and lactation was an additional risk factor in low income groups. The situation may increase the risk of bone loss.

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Occult Osteomalacia Amongst Healthy and Pregnant Women in Pakistan

Cited by 48 publications

References 6 publications

High prevalence of vitamin D and calcium deficiency among pregnant women and their newborns in Chengdu, China

High prevalence of vitamin D and calcium deficiency among pregnant women and their newborns in Chengdu, China

Effects of Vitamin D Supplementation in Pregnancy

Vitamin D deficiency: a concern in premenopausal Bangladeshi women of two socio-economic groups in rural and urban region

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